Detailed information NTG1170159

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: ACLV65_RS10270
• Genome accession: NZ_OZ217342
• Coordinates: 2095397..2096578 (+)
• Length: 393 a.a.
• NCBI ID: WP_411865194.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis B22
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2090397..2101578

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV65_RS10230 (SMIB22_20200)	-	2091446..2091988 (+)	543	WP_119941849.1	TetR/AcrR family transcriptional regulator	-
ACLV65_RS10245 (SMIB22_20230)	comE	2092231..2092983 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
ACLV65_RS10250 (SMIB22_20240)	comD/comD2	2092980..2094305 (-)	1326	WP_164226121.1	competence system sensor histidine kinase ComD	Regulator
ACLV65_RS10255 (SMIB22_20250)	comC/comC2	2094326..2094451 (-)	126	WP_112445417.1	competence-stimulating peptide ComC	Regulator
ACLV65_RS10265 (SMIB22_20270)	rlmH	2094734..2095213 (-)	480	WP_000695934.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACLV65_RS10270 (SMIB22_20280)	htrA	2095397..2096578 (+)	1182	WP_411865194.1	S1C family serine protease	Regulator
ACLV65_RS10275 (SMIB22_20290)	spo0J	2096636..2097394 (+)	759	WP_411865195.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41628.43 Da
• Isoelectric Point: 6.1486

>NTDB_id=1170159 ACLV65_RS10270 WP_411865194.1 2095397..2096578(+) (htrA) [Streptococcus mitis isolate S. mitis B22]
MKHLKTFYKKGFQLLVVIVISFFSGALGSFSIAQLTQKSSVSNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNISTSDIRRLNIPSSVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQNALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=1170159 ACLV65_RS10270 WP_411865194.1 2095397..2096578(+) (htrA) [Streptococcus mitis isolate S. mitis B22]
ATGAAACATTTAAAAACATTTTACAAAAAAGGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAGCTCAACTAACTCAAAAAAGTAGTGTAAGCAACTCTAACAACAATAGTACTATCACACAGACTG
CCTATAAGAATGAAAATTCAACAACTCAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCAGCT
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCAAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCTAGCAAAGTAGATATTCGCT
TGTCAGATGGGACTAAAGTACCTGGAGAAATCGTCGGAGCGGATACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACCGTAGGAGAAACTGCTATTGCTATTGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTTACTCAAGGTATCGTATCTAGTCTCAATCGAAATGTATCCTTAAAATCTGAAG
ATGGACAAGCCATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGTGGGCCACTAATCAAT
ATTCAAGGACAAGTTATTGGAATTACGTCAAGTAAAATTGCCACAAATGGAGGAACATCTGTAGAAGGCCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGTATCC
AGATGGTTAATTTATCTAATATAAGTACAAGCGACATCAGAAGACTTAATATTCCAAGCAGTGTAACATCTGGTGTAGTT
GTTCGTTCTGTGCAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTGATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAATGCTCTTTACAATCATTCCATTGGAGACACCATTAAGATCACTTACTATCGCA
ACGGTAAAGAAGAAACTACATCCATCAAGCTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (289-384)

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mitis NCTC 12261	98.219	100	0.982
htrA	Streptococcus pneumoniae Rx1	97.71	100	0.977
htrA	Streptococcus pneumoniae D39	97.71	100	0.977
htrA	Streptococcus pneumoniae R6	97.71	100	0.977
htrA	Streptococcus pneumoniae TIGR4	97.71	100	0.977
htrA	Streptococcus gordonii str. Challis substr. CH1	66.162	100	0.667
htrA	Streptococcus mutans UA159	54.569	100	0.547