Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   ACLV65_RS10250 Genome accession   NZ_OZ217342
Coordinates   2092980..2094305 (-) Length   441 a.a.
NCBI ID   WP_164226121.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis B22     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2087980..2099305
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV65_RS10225 (SMIB22_20190) - 2088664..2091318 (-) 2655 WP_411865193.1 YhgE/Pip family protein -
  ACLV65_RS10230 (SMIB22_20200) - 2091446..2091988 (+) 543 WP_119941849.1 TetR/AcrR family transcriptional regulator -
  ACLV65_RS10245 (SMIB22_20230) comE 2092231..2092983 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  ACLV65_RS10250 (SMIB22_20240) comD/comD2 2092980..2094305 (-) 1326 WP_164226121.1 competence system sensor histidine kinase ComD Regulator
  ACLV65_RS10255 (SMIB22_20250) comC/comC2 2094326..2094451 (-) 126 WP_112445417.1 competence-stimulating peptide ComC Regulator
  ACLV65_RS10265 (SMIB22_20270) rlmH 2094734..2095213 (-) 480 WP_000695934.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ACLV65_RS10270 (SMIB22_20280) htrA 2095397..2096578 (+) 1182 WP_411865194.1 S1C family serine protease Regulator
  ACLV65_RS10275 (SMIB22_20290) spo0J 2096636..2097394 (+) 759 WP_411865195.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51297.78 Da        Isoelectric Point: 6.9346

>NTDB_id=1170157 ACLV65_RS10250 WP_164226121.1 2092980..2094305(-) (comD/comD2) [Streptococcus mitis isolate S. mitis B22]
MDLLGFGTVIVHFLIISHSYRLICKGQINRKELYVFGIYTLLVEAVLELSFYLPYLDKIGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVSQYHFPFFFVVTVLTYVVILKIIHYFHLELTYFDKDYLYPFLKK
VFFALLLLHLLSFVSDIVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKEQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGDLQEIDRVYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=1170157 ACLV65_RS10250 WP_164226121.1 2092980..2094305(-) (comD/comD2) [Streptococcus mitis isolate S. mitis B22]
ATGGATTTACTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCA
AATAAATAGAAAAGAACTATATGTTTTTGGTATCTATACATTACTAGTAGAAGCAGTACTTGAACTTTCCTTTTATCTTC
CATATTTAGATAAAATAGGGATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGACAATTTTGTTTCACAATATCATTTCCCATTCTTTTTCGTTGTAACGGTGTTGACTTATGTTG
TTATATTAAAAATCATTCATTATTTCCACTTAGAACTAACCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGTTACATCTTTTATCTTTCGTTTCAGATATAGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATCTTGTCATCTATTGTCTTTATTTCTCTCCTTTTGACCTTCTTTGCAATGAATTCGCATAAAGAACAAATGG
AAAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTATACAGATGAAATTGTCGGACTGTAT
AATGAAATCCGTGGTTTTCGACATGACTATGCTGGAATGCTTGTCAGTATGCAGATGGCAATTGACAGTGGTGATTTACA
GGAAATTGACAGAGTTTACAATGAAGTTTTGGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGATTCAGCTTTACGAAGTTTGGTTGCTCAGTCTATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTCCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
CAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCTTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGGGTAGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATTATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus pneumoniae TIGR4

95.918

100

0.959
  comD/comD1 Streptococcus pneumoniae Rx1

93.651

100

0.937
  comD/comD1 Streptococcus pneumoniae D39

93.651

100

0.937
  comD/comD1 Streptococcus pneumoniae R6

93.651

100

0.937
  comD Streptococcus mitis SK321

91.156

100

0.912
  comD Streptococcus mitis NCTC 12261

87.755

100

0.878
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.733

84.807

0.422
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.468

85.261

0.422

Multiple sequence alignment