Detailed information NTG1161756

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: U8955_RS10110
• Genome accession: NZ_OY769914
• Coordinates: 2015551..2016303 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866081.1
• Uniprot ID: A0A428BMV3
• Organism: Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2010551..2021303

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U8955_RS10090 (SDENT7746_10145)	-	2012002..2014644 (-)	2643	WP_038804777.1	YhgE/Pip domain-containing protein	-
U8955_RS10095 (SDENT7746_10150)	-	2014773..2015315 (+)	543	WP_038804778.1	TetR/AcrR family transcriptional regulator	-
U8955_RS10110 (SDENT7746_10165)	comE	2015551..2016303 (-)	753	WP_000866081.1	competence system response regulator transcription factor ComE	Regulator
U8955_RS10115 (SDENT7746_10170)	comD	2016300..2017619 (-)	1320	WP_038804779.1	competence system sensor histidine kinase ComD	Regulator
U8955_RS10120 (SDENT7746_10175)	comC	2017641..2017766 (-)	126	WP_000799680.1	competence-stimulating peptide ComC	Regulator
U8955_RS10130 (SDENT7746_10185)	rlmH	2018050..2018529 (-)	480	WP_038804781.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29920.29 Da
• Isoelectric Point: 6.9820

>NTDB_id=1161756 U8955_RS10110 WP_000866081.1 2015551..2016303(-) (comE) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLINIGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKTKK

Nucleotide

• Length: 753 bp

>NTDB_id=1161756 U8955_RS10110 WP_000866081.1 2015551..2016303(-) (comE) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAGCATCAAGTGAGACTAGAGAGAATATTGAATGAAATCTCGGAGGAATC
AAATATTCCTATTTCTTACAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCACGGAATTGAGAAAAAGGGCTTTGAAGTGGCACAGTTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACCAGTCGATCTGAATTTGCTACCTTAACGTACAAATACCAGGTATCAGCTCTAGATTT
TGTAGACAAAGACATCAATGATGAATTGTTCAAAAAACGTATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAGGGAAATGATTTGAAAATCCCTTACCATGATATTTTGTAT
ATCGAAACAACAGGTGTTTCTCATAAACTGCGGATTATTGGTAAGAATTTTGCCAAAGAGTTCTATGGAACCATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTCTCCTCATAAATCTTTCCTAATCAATATTGGAAATGTTAGAG
AAATTGATCGAAAGAATCTAGAAGTTGTCTTTTATGAAGATCATCGCTGCCCCATCACTCGTTTGAAAGTTCGTAAACTG
AAAGATATTCTAGAGAAAAAAACTAAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: A0A428BMV3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	96	100	0.96
comE	Streptococcus mitis SK321	95.2	100	0.952
comE	Streptococcus pneumoniae Rx1	94.4	100	0.944
comE	Streptococcus pneumoniae D39	94.4	100	0.944
comE	Streptococcus pneumoniae R6	94.4	100	0.944
comE	Streptococcus pneumoniae TIGR4	94.4	100	0.944
comE	Streptococcus infantis strain Atu-4	92.8	100	0.928
comE/comE2	Streptococcus gordonii strain NCTC7865	64	100	0.64
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	64	100	0.64
comE/blpR	Streptococcus mutans UA159	40.081	98.8	0.396