Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD   Type   Regulator
Locus tag   U8955_RS10115 Genome accession   NZ_OY769914
Coordinates   2016300..2017619 (-) Length   439 a.a.
NCBI ID   WP_038804779.1    Uniprot ID   -
Organism   Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2011300..2022619
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U8955_RS10090 (SDENT7746_10145) - 2012002..2014644 (-) 2643 WP_038804777.1 YhgE/Pip domain-containing protein -
  U8955_RS10095 (SDENT7746_10150) - 2014773..2015315 (+) 543 WP_038804778.1 TetR/AcrR family transcriptional regulator -
  U8955_RS10110 (SDENT7746_10165) comE 2015551..2016303 (-) 753 WP_000866081.1 competence system response regulator transcription factor ComE Regulator
  U8955_RS10115 (SDENT7746_10170) comD 2016300..2017619 (-) 1320 WP_038804779.1 competence system sensor histidine kinase ComD Regulator
  U8955_RS10120 (SDENT7746_10175) comC 2017641..2017766 (-) 126 WP_000799680.1 competence-stimulating peptide ComC Regulator
  U8955_RS10130 (SDENT7746_10185) rlmH 2018050..2018529 (-) 480 WP_038804781.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -

Sequence

Protein


Download         Length: 439 a.a.        Molecular weight: 51360.05 Da        Isoelectric Point: 5.3406

>NTDB_id=1161757 U8955_RS10115 WP_038804779.1 2016300..2017619(-) (comD) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
MNLFGLVIAFFYVFIISKIYEWTCNATKKEKYIYSLYVFLLQLILEEIMYLLALDGYGLSKFLFPLLIFGYFVGFQKYDK
SKGVFISLLFSLLYHSSNNFISVTLSSITGDDIALEYNNYFIIFVLILTYLVIKIVISYFHLEFKYFDKEYLYSFLKKVL
YAFIFLHIVSFISDIVSTISHLNSFGSILSTIVFICLLLIFFAMNSYKVQIEKEIALKQKKFEQKHLQTYTDEIVKLYNE
IRGFRHDYAGMLVSMQMAIDSEDLQEIDRVYNEVLVKANQKLRSEKYTYFDLNNLEDSALRSLIAQSIVYARNNDVEFTL
EVKDVITRLSMDLLDLVRIMSILLNNAVEGAADSYLKQMEVAVIKMDFETVIVIQNSCKITMTPSEDLFALGFSTKGRNR
GLGLNNVKEILDKYDNIMLETEMEDNTFRQIIRFKREFE

Nucleotide


Download         Length: 1320 bp        

>NTDB_id=1161757 U8955_RS10115 WP_038804779.1 2016300..2017619(-) (comD) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
ATGAATTTATTTGGATTAGTAATAGCTTTTTTTTATGTTTTTATCATTAGTAAAATTTATGAATGGACTTGTAATGCAAC
TAAAAAAGAAAAATATATTTATAGTCTTTATGTCTTTTTACTACAATTAATATTAGAAGAAATAATGTATTTGCTAGCCT
TAGATGGTTACGGTTTGTCTAAATTTTTATTTCCTTTACTCATATTCGGTTACTTTGTTGGATTTCAGAAGTATGATAAG
TCTAAGGGAGTTTTTATAAGCCTATTATTTTCTCTCTTATATCATAGTAGTAATAACTTTATATCGGTAACTTTATCATC
TATAACAGGAGATGATATTGCATTAGAATATAATAATTATTTTATTATATTTGTACTTATTTTAACCTATTTGGTTATTA
AAATTGTCATATCTTATTTCCATTTGGAGTTTAAATATTTTGACAAAGAATATCTCTATTCTTTTTTGAAAAAAGTGCTA
TATGCATTTATCTTCTTGCATATCGTCTCTTTTATTTCAGATATCGTGAGTACTATTTCTCATTTAAATAGTTTTGGAAG
TATTTTATCAACCATTGTTTTTATTTGCTTGTTATTGATTTTCTTTGCAATGAATTCTTATAAGGTTCAAATTGAAAAAG
AGATTGCCCTAAAGCAGAAGAAATTTGAACAAAAGCATTTACAGACTTATACTGATGAAATTGTCAAGTTGTATAATGAA
ATTCGAGGTTTTCGTCATGACTATGCAGGTATGCTTGTCAGCATGCAAATGGCAATTGACAGTGAAGATTTACAGGAAAT
TGACAGAGTTTACAATGAAGTATTAGTAAAAGCGAATCAAAAACTGCGTTCAGAAAAATATACTTACTTTGATTTGAACA
ATTTAGAAGATTCAGCTTTACGTAGTTTGATTGCTCAATCCATTGTTTATGCACGAAATAATGATGTAGAGTTTACATTG
GAAGTAAAGGATGTTATTACTAGATTGTCAATGGATTTACTTGATCTTGTTCGCATCATGAGTATTCTCTTAAACAATGC
TGTTGAAGGAGCCGCGGATAGTTACTTGAAACAAATGGAAGTTGCAGTCATTAAAATGGATTTTGAGACAGTTATAGTCA
TCCAGAATTCATGTAAAATCACTATGACGCCTTCAGAGGACTTATTTGCCTTAGGTTTCTCTACCAAGGGAAGAAATAGA
GGTTTAGGGCTTAATAATGTCAAAGAGATTCTAGATAAATATGACAACATTATGTTAGAAACAGAGATGGAAGACAACAC
ATTTAGACAAATTATTAGATTTAAGAGGGAATTCGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(332-432)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD Streptococcus mitis SK321

72.562

100

0.729
  comD Streptococcus mitis NCTC 12261

72.336

100

0.727
  comD/comD2 Streptococcus pneumoniae TIGR4

71.202

100

0.715
  comD/comD1 Streptococcus pneumoniae R6

70.748

100

0.711
  comD/comD1 Streptococcus pneumoniae Rx1

70.748

100

0.711
  comD/comD1 Streptococcus pneumoniae D39

70.748

100

0.711
  comD/comD2 Streptococcus gordonii strain NCTC7865

48.67

85.649

0.417
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

48.396

85.194

0.412

Multiple sequence alignment