Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC   Type   Regulator
Locus tag   U8955_RS10120 Genome accession   NZ_OY769914
Coordinates   2017641..2017766 (-) Length   41 a.a.
NCBI ID   WP_000799680.1    Uniprot ID   A0A428FUE9
Organism   Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 2012641..2022766
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U8955_RS10095 (SDENT7746_10150) - 2014773..2015315 (+) 543 WP_038804778.1 TetR/AcrR family transcriptional regulator -
  U8955_RS10110 (SDENT7746_10165) comE 2015551..2016303 (-) 753 WP_000866081.1 competence system response regulator transcription factor ComE Regulator
  U8955_RS10115 (SDENT7746_10170) comD 2016300..2017619 (-) 1320 WP_038804779.1 competence system sensor histidine kinase ComD Regulator
  U8955_RS10120 (SDENT7746_10175) comC 2017641..2017766 (-) 126 WP_000799680.1 competence-stimulating peptide ComC Regulator
  U8955_RS10130 (SDENT7746_10185) rlmH 2018050..2018529 (-) 480 WP_038804781.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4998.87 Da        Isoelectric Point: 10.1884

>NTDB_id=1161758 U8955_RS10120 WP_000799680.1 2017641..2017766(-) (comC) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
MKNTVKLEQFKEVTETELQEIRGGEWRIPELIRNLIFPKRK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=1161758 U8955_RS10120 WP_000799680.1 2017641..2017766(-) (comC) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
ATGAAAAATACAGTAAAGTTGGAACAATTTAAAGAAGTAACAGAAACAGAATTGCAGGAGATTCGGGGTGGGGAATGGAG
AATTCCAGAATTAATACGTAATCTTATTTTTCCAAAAAGAAAATAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-27)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A428FUE9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC Streptococcus mitis SK321

58.537

100

0.585
  comC/comC2 Streptococcus pneumoniae A66

53.659

100

0.537
  comC/comC2 Streptococcus pneumoniae TIGR4

53.659

100

0.537
  comC/comC1 Streptococcus pneumoniae R6

51.22

100

0.512
  comC/comC1 Streptococcus pneumoniae G54

51.22

100

0.512
  comC/comC1 Streptococcus pneumoniae D39

51.22

100

0.512
  comC/comC1 Streptococcus pneumoniae Rx1

51.22

100

0.512
  comC Streptococcus mitis NCTC 12261

47.5

97.561

0.463
  comC/comC2 Streptococcus gordonii strain NCTC7865

43.243

90.244

0.39

Multiple sequence alignment