Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   BUC38_RS12040 Genome accession   NZ_LT671674
Coordinates   2459120..2459857 (-) Length   245 a.a.
NCBI ID   WP_044690533.1    Uniprot ID   -
Organism   Streptococcus suis strain LS9N     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 2451583..2459857 2459120..2459857 within 0


Gene organization within MGE regions


Location: 2451583..2459857
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BUC38_RS11970 - 2451583..2452257 (-) 675 WP_044690542.1 type II CAAX endopeptidase family protein -
  BUC38_RS11975 - 2452584..2453003 (-) 420 WP_052503077.1 hypothetical protein -
  BUC38_RS11980 - 2453243..2453530 (+) 288 WP_024398776.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  BUC38_RS11985 - 2453520..2453861 (+) 342 WP_032511322.1 type II toxin-antitoxin system RelE/ParE family toxin -
  BUC38_RS11990 - 2454188..2454382 (-) 195 WP_044690541.1 hypothetical protein -
  BUC38_RS11995 - 2454404..2455105 (-) 702 WP_044690540.1 type II CAAX endopeptidase family protein -
  BUC38_RS12000 - 2455109..2455519 (-) 411 WP_044690539.1 hypothetical protein -
  BUC38_RS12005 - 2455554..2455736 (-) 183 WP_044690538.1 hypothetical protein -
  BUC38_RS12010 - 2455760..2455975 (-) 216 WP_024376181.1 hypothetical protein -
  BUC38_RS12015 - 2456003..2456212 (-) 210 WP_044690537.1 hypothetical protein -
  BUC38_RS12020 - 2456324..2456533 (-) 210 WP_044690536.1 hypothetical protein -
  BUC38_RS12030 - 2457466..2457624 (-) 159 WP_002942002.1 hypothetical protein -
  BUC38_RS12035 - 2457786..2459120 (-) 1335 WP_044690535.1 GHKL domain-containing protein -
  BUC38_RS12040 comE/blpR 2459120..2459857 (-) 738 WP_044690533.1 response regulator transcription factor Regulator

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28326.13 Da        Isoelectric Point: 5.0757

>NTDB_id=1146018 BUC38_RS12040 WP_044690533.1 2459120..2459857(-) (comE/blpR) [Streptococcus suis strain LS9N]
MLNIFVLEDDFFQQSRLENAIRQCVEETSVRYKFLEVFGKPNQLLESIEEAGNHQFFFLDIEIKGEEKKGMEIAKEIRAR
DPYAVIVFVTTHSEFMPVTYRYRVSALDFIDKGLEDSDFQKAVSDVLVHAFENIDHTVAENSFVYKTETAHIQVPFSDIL
YFETSSTIHKVILKTKTGQTEFYGKVSDIAKADERLYQAHRSCVVNPLNITKLDRANHIAYFENGDSCFVSRLKQKKLAD
LLEID

Nucleotide


Download         Length: 738 bp        

>NTDB_id=1146018 BUC38_RS12040 WP_044690533.1 2459120..2459857(-) (comE/blpR) [Streptococcus suis strain LS9N]
ATGCTTAATATTTTTGTATTAGAAGATGATTTTTTTCAGCAGAGTAGGCTAGAAAATGCTATTAGGCAGTGTGTTGAAGA
AACGTCAGTAAGATATAAATTCCTAGAAGTTTTTGGTAAACCGAATCAATTATTGGAATCAATCGAGGAAGCGGGGAATC
ACCAATTTTTCTTTTTAGATATTGAAATAAAAGGAGAAGAAAAGAAAGGAATGGAAATCGCTAAAGAAATCCGTGCTCGA
GATCCTTATGCTGTTATTGTCTTTGTAACAACTCACTCAGAATTTATGCCGGTAACGTATCGTTATCGAGTCTCTGCTTT
AGATTTTATAGATAAAGGCCTGGAGGATAGTGACTTTCAAAAGGCAGTATCAGATGTGTTAGTGCATGCTTTTGAAAATA
TTGATCATACTGTAGCTGAAAATTCTTTTGTATATAAAACTGAAACTGCTCATATTCAAGTCCCTTTTAGTGACATCCTT
TATTTTGAAACATCATCAACGATTCATAAAGTCATTTTAAAAACGAAAACAGGTCAGACTGAGTTTTACGGGAAAGTATC
CGATATAGCTAAAGCTGACGAACGACTTTACCAGGCACATCGTTCTTGTGTAGTGAATCCTTTAAATATAACGAAGTTGG
ACAGAGCAAACCATATTGCCTATTTTGAGAATGGAGATTCTTGTTTTGTTTCTCGTTTGAAGCAGAAGAAACTTGCAGAT
TTGTTGGAGATTGATTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(152-242)

Response regulator receiver domain (Response_reg)

(4-123)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.23

97.551

0.539
  comE/comE1 Streptococcus equinus JB1

50

97.143

0.486
  comE/comE2 Streptococcus equinus JB1

40.741

99.184

0.404
  comE Streptococcus mitis SK321

38.554

100

0.392
  comE Streptococcus pneumoniae R6

38.554

100

0.392
  comE Streptococcus pneumoniae TIGR4

38.554

100

0.392
  comE Streptococcus infantis strain Atu-4

38.554

100

0.392
  comE Streptococcus mitis NCTC 12261

38.554

100

0.392
  comE Streptococcus pneumoniae Rx1

38.554

100

0.392
  comE Streptococcus pneumoniae D39

38.554

100

0.392
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

38.618

100

0.388
  comE/comE2 Streptococcus gordonii strain NCTC7865

38.618

100

0.388

Multiple sequence alignment