Detailed information NTG1142931

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: DQL00_RS02690
• Genome accession: NZ_LS483523
• Coordinates: 505118..505870 (+)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 4041STDY6836169
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 500118..510870

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL00_RS02660	spo0J	500709..501467 (-)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator
DQL00_RS02665	htrA	501525..502706 (-)	1182	WP_000681601.1	S1C family serine protease	Regulator
DQL00_RS02670	rlmH	502889..503368 (+)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQL00_RS02680	comC/comC1	503650..503775 (+)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
DQL00_RS02685	comD/comD1	503796..505121 (+)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
DQL00_RS02690	comE	505118..505870 (+)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
DQL00_RS02705	-	506113..506655 (-)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
DQL00_RS12335	-	506762..507939 (+)	1178	Protein_506	YhgE/Pip family protein	-
DQL00_RS02715	-	507969..510521 (-)	2553	WP_000834682.1	YfhO family protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=1142931 DQL00_RS02690 WP_000866065.1 505118..505870(+) (comE) [Streptococcus pneumoniae strain 4041STDY6836169]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=1142931 DQL00_RS02690 WP_000866065.1 505118..505870(+) (comE) [Streptococcus pneumoniae strain 4041STDY6836169]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATATCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408