Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   DQL00_RS02665 Genome accession   NZ_LS483523
Coordinates   501525..502706 (-) Length   393 a.a.
NCBI ID   WP_000681601.1    Uniprot ID   A0A0B7LRW6
Organism   Streptococcus pneumoniae strain 4041STDY6836169     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 496525..507706
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL00_RS02645 - 497581..497775 (-) 195 WP_000285194.1 DUF951 domain-containing protein -
  DQL00_RS02650 dnaN 497840..498976 (-) 1137 WP_000581157.1 DNA polymerase III subunit beta -
  DQL00_RS02655 dnaA 499135..500496 (-) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -
  DQL00_RS02660 spo0J 500709..501467 (-) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator
  DQL00_RS02665 htrA 501525..502706 (-) 1182 WP_000681601.1 S1C family serine protease Regulator
  DQL00_RS02670 rlmH 502889..503368 (+) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  DQL00_RS02680 comC/comC1 503650..503775 (+) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  DQL00_RS02685 comD/comD1 503796..505121 (+) 1326 WP_000362880.1 competence system sensor histidine kinase ComD Regulator
  DQL00_RS02690 comE 505118..505870 (+) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  DQL00_RS02705 - 506113..506655 (-) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41855.70 Da        Isoelectric Point: 6.8902

>NTDB_id=1142928 DQL00_RS02665 WP_000681601.1 501525..502706(-) (htrA) [Streptococcus pneumoniae strain 4041STDY6836169]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=1142928 DQL00_RS02665 WP_000681601.1 501525..502706(-) (htrA) [Streptococcus pneumoniae strain 4041STDY6836169]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTAGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAGATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTGA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7LRW6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

99.491

100

0.995
  htrA Streptococcus pneumoniae D39

99.491

100

0.995
  htrA Streptococcus pneumoniae R6

99.491

100

0.995
  htrA Streptococcus pneumoniae TIGR4

99.491

100

0.995
  htrA Streptococcus mitis NCTC 12261

97.201

100

0.972
  htrA Streptococcus gordonii str. Challis substr. CH1

66.919

100

0.674
  htrA Streptococcus mutans UA159

54.822

100

0.55

Multiple sequence alignment