Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   DQN71_RS06670 Genome accession   NZ_LS483471
Coordinates   1264329..1265060 (-) Length   243 a.a.
NCBI ID   WP_015605157.1    Uniprot ID   A0A512A9N5
Organism   Streptococcus cristatus strain NCTC13807     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1259329..1270060
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN71_RS06650 (NCTC13807_01274) - 1259850..1261010 (-) 1161 WP_015605153.1 ABC transporter permease subunit -
  DQN71_RS06655 (NCTC13807_01275) - 1261007..1261870 (-) 864 WP_015605154.1 ABC transporter ATP-binding protein -
  DQN71_RS11585 (NCTC13807_01277) - 1262962..1264296 (-) 1335 WP_015605156.1 sensor histidine kinase -
  DQN71_RS06670 (NCTC13807_01278) comE/blpR 1264329..1265060 (-) 732 WP_015605157.1 response regulator transcription factor Regulator
  DQN71_RS06675 (NCTC13807_01279) - 1265062..1265403 (-) 342 WP_015605158.1 LytTR family DNA-binding domain-containing protein -
  DQN71_RS06680 (NCTC13807_01280) - 1265586..1266158 (-) 573 WP_015605159.1 TetR/AcrR family transcriptional regulator -
  DQN71_RS06685 (NCTC13807_01281) - 1266285..1267127 (+) 843 WP_015605160.1 DegV family protein -
  DQN71_RS06690 (NCTC13807_01282) - 1267218..1268006 (+) 789 WP_111694563.1 XRE family transcriptional regulator -
  DQN71_RS06695 (NCTC13807_01283) - 1268164..1268661 (-) 498 WP_015604538.1 hypothetical protein -
  DQN71_RS06700 (NCTC13807_01284) - 1268732..1269214 (-) 483 WP_015604537.1 hypothetical protein -
  DQN71_RS06705 (NCTC13807_01285) - 1269207..1269752 (-) 546 WP_015604536.1 DUF1697 domain-containing protein -

Sequence

Protein


Download         Length: 243 a.a.        Molecular weight: 28706.87 Da        Isoelectric Point: 5.4721

>NTDB_id=1142319 DQN71_RS06670 WP_015605157.1 1264329..1265060(-) (comE/blpR) [Streptococcus cristatus strain NCTC13807]
MKIFVLEDDLKQQAYMESTIKGILEKNGWECQFLEIYGKPDMLIDAVRERGSHQIFFLDIEIKQETQKGLEVAGKIRKLD
PYALIVFVTTHSEFMPLTFRYQVSAFDFIDKGLPEEDFIKQIEQDLAYLYERKDSFQAEETFVFENSKSDFQVPFSEIYY
FETSEVPHRLVLYTKKERIEFYGQLSEITKQDKRLYRCHRSYVVNPANISQLDKIENIAYFPNGASCYVSRLKMKGLRAA
LRQ

Nucleotide


Download         Length: 732 bp        

>NTDB_id=1142319 DQN71_RS06670 WP_015605157.1 1264329..1265060(-) (comE/blpR) [Streptococcus cristatus strain NCTC13807]
ATGAAAATTTTTGTATTAGAAGACGATCTTAAGCAACAAGCCTATATGGAGTCAACCATTAAGGGAATTTTGGAAAAGAA
TGGCTGGGAATGCCAGTTTTTAGAAATCTACGGCAAGCCGGACATGCTGATTGATGCAGTAAGGGAACGGGGGAGTCATC
AGATTTTCTTTTTGGATATTGAGATTAAGCAAGAGACGCAGAAGGGACTAGAGGTGGCAGGAAAGATTCGCAAGTTGGAT
CCCTATGCTCTGATTGTATTTGTGACGACTCACTCAGAATTTATGCCCTTGACTTTTCGCTATCAGGTATCAGCTTTTGA
CTTTATTGATAAAGGTTTGCCTGAGGAAGATTTTATCAAGCAGATTGAGCAGGACCTAGCCTATCTTTATGAGAGAAAGG
ACAGTTTTCAAGCTGAAGAAACTTTTGTCTTTGAAAATTCCAAATCAGATTTTCAGGTGCCTTTTAGTGAAATCTATTAT
TTTGAGACATCAGAAGTGCCTCATAGACTCGTTCTCTATACCAAGAAAGAGCGGATCGAATTTTACGGACAGCTTTCTGA
GATTACAAAGCAGGACAAGCGTCTCTATCGGTGTCATCGCTCTTATGTGGTCAATCCAGCGAATATCTCTCAGCTGGATA
AGATAGAAAACATAGCCTATTTTCCTAATGGCGCTAGTTGCTATGTATCACGCCTCAAGATGAAAGGATTGCGGGCAGCT
TTAAGGCAGTAG

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-241)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A512A9N5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

57.438

99.588

0.572
  comE/comE1 Streptococcus equinus JB1

45.868

99.588

0.457
  comE/comE2 Streptococcus equinus JB1

44.398

99.177

0.44
  comE/comE2 Streptococcus gordonii strain NCTC7865

37.751

100

0.387
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

37.751

100

0.387
  comE Streptococcus infantis strain Atu-4

36.4

100

0.374
  comE Streptococcus mitis NCTC 12261

35.6

100

0.366
  comE Streptococcus mitis SK321

35.6

100

0.366
  comE Streptococcus pneumoniae Rx1

35.6

100

0.366
  comE Streptococcus pneumoniae D39

35.6

100

0.366
  comE Streptococcus pneumoniae R6

35.6

100

0.366
  comE Streptococcus pneumoniae TIGR4

35.6

100

0.366

Multiple sequence alignment