Detailed information NTG1141764

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: DQL20_RS10720
• Genome accession: NZ_LS483444
• Coordinates: 2155960..2156712 (-)
• Length: 250 a.a.
• NCBI ID: WP_006595334.1
• Uniprot ID: E7S8N2
• Organism: Streptococcus australis strain NCTC13166
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2150960..2161712

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL20_RS10700 (NCTC11371_02084)	-	2151115..2152737 (+)	1623	WP_006595336.1	ATP-binding cassette domain-containing protein	-
DQL20_RS10705 (NCTC11371_02085)	-	2152800..2155388 (+)	2589	WP_006595335.1	YfhO family protein	-
DQL20_RS10720 (NCTC11371_02088)	comE/comE2	2155960..2156712 (-)	753	WP_006595334.1	response regulator transcription factor	Regulator
DQL20_RS10725 (NCTC11371_02089)	-	2156713..2158038 (-)	1326	WP_006595333.1	GHKL domain-containing protein	-
DQL20_RS10730 (NCTC11371_02090)	-	2158038..2158169 (-)	132	WP_006595332.1	bacteriocin	-
DQL20_RS10740 (NCTC11371_02092)	rlmH	2158529..2159008 (-)	480	WP_040802864.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQL20_RS10745 (NCTC11371_02093)	htrA	2159211..2160389 (+)	1179	WP_006595330.1	S1C family serine protease	Regulator
DQL20_RS10750 (NCTC11371_02094)	spo0J	2160455..2161216 (+)	762	WP_006595329.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29467.23 Da
• Isoelectric Point: 8.4082

>NTDB_id=1141764 DQL20_RS10720 WP_006595334.1 2155960..2156712(-) (comE/comE2) [Streptococcus australis strain NCTC13166]
MNIVLLEDEISQQVRVEKHVKAIAEEEGLRLNIVSTSKITELKEYLTNGDFHQLFFLDIDIKGDEKAGIKAAQMIREVNP
FAIIAFITTKSEFATITYRYKVSALEFIEKTLNENLFKEKIRECILYLKKNVIENKNIIDFFEYSFKNMEIRVPYRDILY
IETTGVSHKLRLVGKNFQKEFLGTIKDILEKDVDNHFFSPNQSYLVNQRMIVNFDRRKRLLMLEEETTCPVSRTQVKRVE
ELLNKIQKKA

Nucleotide

• Length: 753 bp

>NTDB_id=1141764 DQL20_RS10720 WP_006595334.1 2155960..2156712(-) (comE/comE2) [Streptococcus australis strain NCTC13166]
ATGAATATTGTATTGCTAGAGGACGAAATTTCTCAACAAGTTCGAGTAGAGAAACATGTGAAAGCTATCGCTGAGGAGGA
AGGACTACGATTAAATATTGTTTCCACCAGTAAAATAACTGAACTAAAGGAATACCTAACCAATGGTGATTTTCATCAGC
TTTTCTTCCTTGATATTGATATCAAAGGGGATGAAAAAGCTGGCATCAAGGCAGCTCAAATGATTCGCGAGGTCAATCCT
TTTGCAATCATTGCTTTTATTACGACGAAATCGGAATTTGCTACCATTACATATCGTTACAAGGTATCAGCTCTCGAATT
TATTGAAAAAACCTTGAATGAAAACTTGTTTAAAGAAAAAATTCGAGAATGTATTCTCTATTTGAAGAAGAATGTGATTG
AAAATAAAAATATCATTGATTTCTTTGAATATAGTTTCAAAAATATGGAAATTCGAGTTCCATATCGAGATATATTGTAC
ATTGAGACAACTGGAGTTTCCCACAAATTGCGACTTGTTGGAAAGAATTTTCAAAAGGAATTTTTAGGGACTATCAAGGA
TATACTTGAAAAAGATGTAGACAATCATTTCTTTAGTCCCAATCAATCCTATCTAGTGAATCAAAGAATGATTGTCAATT
TTGATCGTCGCAAGAGACTCTTGATGTTAGAAGAGGAGACAACTTGCCCCGTCTCTCGTACACAGGTTAAAAGGGTCGAA
GAATTATTAAATAAAATACAGAAAAAGGCTTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-243)

• Response regulator receiver domain (Response_reg) (18-121)

3D structure

• AlphaFold DB: E7S8N2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus gordonii strain NCTC7865	50	100	0.5
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	50	100	0.5
comE	Streptococcus infantis strain Atu-4	48.8	100	0.488
comE	Streptococcus mitis SK321	47.6	100	0.476
comE	Streptococcus mitis NCTC 12261	47.6	100	0.476
comE	Streptococcus pneumoniae Rx1	46.8	100	0.468
comE	Streptococcus pneumoniae D39	46.8	100	0.468
comE	Streptococcus pneumoniae R6	46.8	100	0.468
comE	Streptococcus pneumoniae TIGR4	46.8	100	0.468
comE/comE1	Streptococcus equinus JB1	37.805	98.4	0.372