Detailed information NTG1141765

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: DQL20_RS10745
• Genome accession: NZ_LS483444
• Coordinates: 2159211..2160389 (+)
• Length: 392 a.a.
• NCBI ID: WP_006595330.1
• Uniprot ID: E7S8M8
• Organism: Streptococcus australis strain NCTC13166
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2154211..2165389

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL20_RS10720 (NCTC11371_02088)	comE/comE2	2155960..2156712 (-)	753	WP_006595334.1	response regulator transcription factor	Regulator
DQL20_RS10725 (NCTC11371_02089)	-	2156713..2158038 (-)	1326	WP_006595333.1	GHKL domain-containing protein	-
DQL20_RS10730 (NCTC11371_02090)	-	2158038..2158169 (-)	132	WP_006595332.1	bacteriocin	-
DQL20_RS10740 (NCTC11371_02092)	rlmH	2158529..2159008 (-)	480	WP_040802864.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQL20_RS10745 (NCTC11371_02093)	htrA	2159211..2160389 (+)	1179	WP_006595330.1	S1C family serine protease	Regulator
DQL20_RS10750 (NCTC11371_02094)	spo0J	2160455..2161216 (+)	762	WP_006595329.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 392 a.a.
• Molecular weight: 41340.64 Da
• Isoelectric Point: 5.2842

>NTDB_id=1141765 DQL20_RS10745 WP_006595330.1 2159211..2160389(+) (htrA) [Streptococcus australis strain NCTC13166]
MKQSSNFLKKALQLLLVLVVGFTGGILGTLTSFQFTKGNSTNSSQEIKSTKVNRAYKNTTSTSEAVDKVKNAVVSVITYA
ETSEKGFINGETDSDPEVASEGSGVIYKKDGKDAYVVTNAHVLMGATEADILFADGNKVSGEVVGSDTFSDIAVVKISSD
NVTTVAEFGDSSKLTVGETAIAIGSPLGTKFANSVTQGIVSSLGRTVKLKSEDGQNVSTKALQTDAAINPGNSGGPLINI
QGQVIGITSSKISSNGQTAVEGMGFAIPVNDVQNIIEHLEKDGKVIRPALGITMMDLANLSSSDLSQLDIPSKLKGGVLV
RSVENDMPASKYLRRLDIITKIDDTTIESTADLQSALYSHQIGDKIKVIFYRDGKQKTATIELTKSTENLGN

Nucleotide

• Length: 1179 bp

>NTDB_id=1141765 DQL20_RS10745 WP_006595330.1 2159211..2160389(+) (htrA) [Streptococcus australis strain NCTC13166]
ATGAAACAATCATCAAATTTTCTAAAAAAAGCTTTGCAACTTTTACTTGTTCTTGTCGTTGGTTTTACTGGAGGAATCTT
AGGAACCTTAACCTCTTTCCAGTTTACCAAAGGGAATTCTACAAATTCTAGTCAAGAAATAAAATCTACCAAAGTCAATC
GTGCTTATAAGAATACAACATCAACTAGTGAAGCCGTTGATAAGGTTAAAAATGCTGTTGTTTCTGTTATTACCTACGCT
GAAACCTCTGAAAAAGGTTTCATCAATGGAGAAACAGATTCTGATCCAGAAGTAGCTAGTGAAGGTTCAGGTGTTATCTA
TAAAAAAGATGGTAAAGACGCTTATGTAGTAACCAATGCTCACGTGTTAATGGGAGCAACAGAAGCCGATATTCTCTTTG
CAGACGGAAATAAAGTTTCCGGAGAAGTTGTTGGTTCCGATACCTTCTCAGATATTGCGGTTGTCAAAATCAGTTCAGAC
AATGTTACGACCGTGGCTGAATTTGGAGATTCATCTAAGTTGACTGTCGGAGAGACCGCAATCGCTATTGGTAGTCCTTT
AGGGACAAAATTTGCCAATTCCGTTACCCAAGGGATTGTCTCTAGTCTCGGACGTACTGTGAAGCTCAAATCAGAAGACG
GACAAAATGTGTCTACAAAAGCGTTGCAAACGGACGCTGCCATCAACCCAGGGAATTCTGGTGGTCCCCTTATCAATATT
CAGGGACAAGTCATCGGAATTACCTCAAGTAAAATCTCTTCAAATGGCCAAACTGCGGTTGAAGGAATGGGATTTGCTAT
TCCTGTAAATGATGTGCAAAATATTATTGAACATTTAGAAAAAGATGGTAAAGTCATTCGTCCAGCTCTTGGAATTACCA
TGATGGACCTGGCTAACCTATCCTCTTCTGATCTTAGCCAATTAGATATTCCAAGCAAACTAAAAGGTGGGGTTCTTGTC
CGCTCAGTTGAAAATGATATGCCGGCATCCAAGTATTTACGTCGTTTAGATATCATTACAAAAATCGATGATACAACCAT
TGAATCAACTGCAGATTTACAATCTGCCCTCTATTCTCATCAAATTGGTGATAAAATCAAAGTTATTTTCTATAGAGATG
GTAAGCAAAAAACAGCAACCATTGAACTAACAAAATCTACAGAAAATCTTGGAAATTAA

Domains

Predicted by InterproScan.

• Peptidase family M50 (Peptidase_M50) (233-388)

• PDZ domain (PDZ_2) (288-383)

• Trypsin-like peptidase domain (Trypsin_2) (102-247)

3D structure

• AlphaFold DB: E7S8M8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mitis NCTC 12261	63.01	100	0.63
htrA	Streptococcus gordonii str. Challis substr. CH1	62.437	100	0.628
htrA	Streptococcus pneumoniae D39	62.755	100	0.628
htrA	Streptococcus pneumoniae TIGR4	62.755	100	0.628
htrA	Streptococcus pneumoniae R6	62.755	100	0.628
htrA	Streptococcus pneumoniae Rx1	62.755	100	0.628
htrA	Streptococcus mutans UA159	52	100	0.531