Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   DQM86_RS00660 Genome accession   NZ_LS483407
Coordinates   101658..102596 (+) Length   312 a.a.
NCBI ID   WP_111674429.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC13744     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 96658..107596
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM86_RS00650 (NCTC13744_00132) rpoC 97407..101048 (+) 3642 WP_111674427.1 DNA-directed RNA polymerase subunit beta' -
  DQM86_RS00655 (NCTC13744_00133) - 101200..101565 (+) 366 WP_002986560.1 DUF1033 family protein -
  DQM86_RS00660 (NCTC13744_00134) comYA 101658..102596 (+) 939 WP_111674429.1 competence type IV pilus ATPase ComGA Machinery gene
  DQM86_RS00665 (NCTC13744_00135) comYB 102532..103566 (+) 1035 WP_225793059.1 competence type IV pilus assembly protein ComGB Machinery gene
  DQM86_RS00670 (NCTC13744_00136) comYC 103568..103894 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  DQM86_RS00675 (NCTC13744_00137) comGD 103869..104297 (+) 429 WP_023605232.1 competence type IV pilus minor pilin ComGD -
  DQM86_RS00680 (NCTC13744_00138) comGE 104254..104538 (+) 285 WP_011284422.1 competence type IV pilus minor pilin ComGE -
  DQM86_RS00685 (NCTC13744_00139) comYF 104531..104965 (+) 435 WP_002992738.1 competence type IV pilus minor pilin ComGF Machinery gene
  DQM86_RS00690 (NCTC13744_00140) comGG 104949..105275 (+) 327 WP_002992739.1 competence type IV pilus minor pilin ComGG -
  DQM86_RS00695 (NCTC13744_00141) comYH 105373..106326 (+) 954 WP_002987790.1 class I SAM-dependent methyltransferase Machinery gene
  DQM86_RS00700 (NCTC13744_00142) - 106385..107581 (+) 1197 WP_002986533.1 acetate kinase -

Sequence

Protein


Download         Length: 312 a.a.        Molecular weight: 35058.36 Da        Isoelectric Point: 9.1037

>NTDB_id=1140429 DQM86_RS00660 WP_111674429.1 101658..102596(+) (comYA) [Streptococcus pyogenes strain NCTC13744]
MVQALAKAILAKAEQVQAQDIYILPRADQYDLFLRIGDERRLVDVYQSDRMAPLISHFKFVAGMIVGEKRRCQVGSCDYK
LSKDKQLSLRLSSVGDYRGQESLVIRLLHHQNKSVHYWFDGLTKVANQVGGRGLYLFAGPVGSGKTTLMYQLISNYHQKA
QVISIEDPVEIKNHQILQLQVNDDIGMTYDNLIKLSLRHRPDILVIGEIRDSQTARAVIRASLTGAMVFSTVHAKSISGV
YARLLELGVTKAELSNCLALIAYQRLLNGGALIDSTQNEFEYYSSSNWNQQIDQLLEAGHLNPKQAKLEKII

Nucleotide


Download         Length: 939 bp        

>NTDB_id=1140429 DQM86_RS00660 WP_111674429.1 101658..102596(+) (comYA) [Streptococcus pyogenes strain NCTC13744]
ATGGTACAAGCATTAGCAAAAGCTATTCTAGCAAAAGCTGAACAGGTTCAGGCACAAGATATTTATATTTTGCCAAGAGC
AGATCAATATGATCTTTTTTTACGAATAGGAGATGAAAGGAGATTAGTTGATGTTTATCAGAGCGATCGGATGGCTCCTC
TTATTAGTCACTTTAAATTCGTTGCAGGAATGATAGTTGGTGAAAAGAGACGTTGTCAGGTGGGTTCATGTGATTATAAG
CTCAGTAAAGATAAGCAGTTATCTTTGCGCTTATCTAGCGTGGGTGATTATCGCGGGCAAGAAAGCTTAGTGATTCGTCT
GCTTCATCATCAAAATAAAAGTGTACATTATTGGTTTGATGGATTGACAAAAGTAGCCAATCAGGTTGGCGGTAGAGGGT
TGTATTTATTTGCAGGACCAGTTGGGTCTGGGAAGACAACCTTGATGTACCAGCTGATTTCGAATTATCATCAAAAAGCA
CAGGTTATTAGTATAGAAGATCCTGTAGAAATTAAAAATCACCAGATTTTACAATTACAAGTGAATGATGATATTGGTAT
GACTTATGACAATTTGATCAAACTGTCTTTACGCCATCGACCAGATATTTTAGTTATTGGTGAGATTCGAGATAGTCAAA
CAGCAAGAGCCGTTATTAGGGCTAGTCTAACAGGTGCCATGGTTTTTTCAACGGTTCACGCTAAAAGTATCTCGGGTGTT
TATGCAAGATTGTTAGAACTTGGTGTAACGAAAGCAGAACTGTCTAATTGCTTAGCATTAATTGCTTACCAAAGGTTACT
TAATGGAGGAGCATTGATTGACTCTACTCAAAACGAATTTGAATATTATTCCTCATCGAACTGGAATCAACAAATTGATC
AGCTTCTTGAGGCAGGACATCTCAATCCCAAGCAAGCTAAGCTTGAAAAAATTATCTAG

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus mutans UA159

61.736

99.679

0.615
  comYA Streptococcus mutans UA140

61.736

99.679

0.615
  comYA Streptococcus gordonii str. Challis substr. CH1

60.772

99.679

0.606
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

60.645

99.359

0.603
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

59.486

99.679

0.593
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

58.842

99.679

0.587
  comGA/cglA/cilD Streptococcus pneumoniae D39

58.842

99.679

0.587
  comGA/cglA/cilD Streptococcus pneumoniae R6

58.842

99.679

0.587
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

58.842

99.679

0.587
  comGA Lactococcus lactis subsp. cremoris KW2

50.482

99.679

0.503
  comGA Latilactobacillus sakei subsp. sakei 23K

39.655

92.949

0.369

Multiple sequence alignment