Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYH   Type   Machinery gene
Locus tag   DQM86_RS00695 Genome accession   NZ_LS483407
Coordinates   105373..106326 (+) Length   317 a.a.
NCBI ID   WP_002987790.1    Uniprot ID   A0A5S4TCX5
Organism   Streptococcus pyogenes strain NCTC13744     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 100373..111326
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM86_RS00655 (NCTC13744_00133) - 101200..101565 (+) 366 WP_002986560.1 DUF1033 family protein -
  DQM86_RS00660 (NCTC13744_00134) comYA 101658..102596 (+) 939 WP_111674429.1 competence type IV pilus ATPase ComGA Machinery gene
  DQM86_RS00665 (NCTC13744_00135) comYB 102532..103566 (+) 1035 WP_225793059.1 competence type IV pilus assembly protein ComGB Machinery gene
  DQM86_RS00670 (NCTC13744_00136) comYC 103568..103894 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  DQM86_RS00675 (NCTC13744_00137) comGD 103869..104297 (+) 429 WP_023605232.1 competence type IV pilus minor pilin ComGD -
  DQM86_RS00680 (NCTC13744_00138) comGE 104254..104538 (+) 285 WP_011284422.1 competence type IV pilus minor pilin ComGE -
  DQM86_RS00685 (NCTC13744_00139) comYF 104531..104965 (+) 435 WP_002992738.1 competence type IV pilus minor pilin ComGF Machinery gene
  DQM86_RS00690 (NCTC13744_00140) comGG 104949..105275 (+) 327 WP_002992739.1 competence type IV pilus minor pilin ComGG -
  DQM86_RS00695 (NCTC13744_00141) comYH 105373..106326 (+) 954 WP_002987790.1 class I SAM-dependent methyltransferase Machinery gene
  DQM86_RS00700 (NCTC13744_00142) - 106385..107581 (+) 1197 WP_002986533.1 acetate kinase -
  DQM86_RS00705 - 107768..108076 (+) 309 WP_011017251.1 hypothetical protein -
  DQM86_RS00710 (NCTC13744_00143) proC 108159..108929 (-) 771 WP_002986527.1 pyrroline-5-carboxylate reductase -
  DQM86_RS00715 (NCTC13744_00144) pepA 108977..110044 (-) 1068 WP_111674431.1 glutamyl aminopeptidase -
  DQM86_RS00725 (NCTC13744_00145) - 110509..110793 (+) 285 WP_002992749.1 DUF4651 domain-containing protein -
  DQM86_RS00730 (NCTC13744_00146) - 110790..111107 (+) 318 WP_002986515.1 thioredoxin family protein -

Sequence

Protein


Download         Length: 317 a.a.        Molecular weight: 35985.08 Da        Isoelectric Point: 4.7205

>NTDB_id=1140433 DQM86_RS00695 WP_002987790.1 105373..106326(+) (comYH) [Streptococcus pyogenes strain NCTC13744]
MTFEKIEEAYQLLLENCQLIENDLKTHIYDAIVEQNSFYLGAEGASPQVAQNSDKLKALCLTKEEWRKAYQFLFIKAAQT
EQLQANHQFTPDAIGFILLYLLEQLSDKDSLEVLEIGSGTGNLAQTLLNNTSKSLDYVGIELDDLLIDLSASIAEIMDSS
AHFIQEDAVRPQLLKESDIVISDLPVGYYPNDDIAKRYKVASSDKHTYAHHLLMEQSLKYLKKDGFAIFLAPVNLLTSPQ
SQLLKQWLKDYAQVVALITLPDSIFGHPSNAKSIIVLQKQTDHPMETFVYPIRDLKLAENIHDFMENFKKWKLSNVN

Nucleotide


Download         Length: 954 bp        

>NTDB_id=1140433 DQM86_RS00695 WP_002987790.1 105373..106326(+) (comYH) [Streptococcus pyogenes strain NCTC13744]
ATGACTTTTGAAAAAATTGAAGAAGCTTATCAGCTGCTCTTAGAGAACTGTCAACTAATTGAAAATGATCTAAAAACACA
TATATACGATGCCATTGTTGAACAAAACTCCTTTTATTTAGGGGCTGAGGGAGCTAGTCCTCAAGTTGCTCAAAATAGTG
ATAAACTGAAAGCCTTGTGCCTGACAAAAGAAGAATGGCGTAAGGCCTACCAGTTTCTTTTTATTAAGGCAGCTCAGACT
GAGCAACTCCAAGCCAACCATCAGTTCACACCAGATGCTATTGGCTTCATTCTGCTGTATCTTTTGGAACAATTGAGTGA
TAAAGATAGCTTAGAGGTACTTGAGATTGGAAGTGGAACAGGGAACCTAGCCCAAACCCTTCTCAACAACACGAGCAAGA
GCCTTGATTATGTAGGGATTGAACTTGATGATCTCTTGATTGATCTGTCAGCCAGTATTGCTGAAATAATGGATTCTTCA
GCTCATTTTATTCAAGAAGATGCGGTAAGGCCTCAATTACTAAAAGAAAGTGACATTGTCATCAGTGACTTACCAGTTGG
TTATTATCCTAACGATGATATTGCCAAACGGTACAAGGTGGCTAGTTCAGATAAGCATACCTATGCCCATCATTTATTAA
TGGAACAGTCTTTAAAATACTTGAAAAAAGACGGTTTTGCGATTTTTCTGGCACCAGTCAATTTATTGACGAGCCCTCAG
AGCCAGTTATTGAAACAGTGGTTAAAAGATTATGCTCAGGTGGTGGCCTTGATTACACTACCAGATTCTATTTTTGGTCA
TCCCTCAAATGCCAAGTCCATTATTGTCTTACAAAAACAAACAGACCACCCAATGGAAACCTTTGTCTATCCAATTCGGG
ATTTGAAGCTTGCAGAGAATATTCATGATTTTATGGAAAATTTCAAAAAATGGAAACTGAGTAATGTCAATTAA

Domains

Predicted by InterproScan.

N-6 DNA Methylase (N6_Mtase)

(68-288)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5S4TCX5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYH Streptococcus mutans UA159

66.139

99.685

0.659
  comYH Streptococcus mutans UA140

65.823

99.685

0.656

Multiple sequence alignment