Detailed information NTG1139663

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: DQM63_RS11495
• Genome accession: NZ_LS483385
• Coordinates: 2291498..2292262 (-)
• Length: 254 a.a.
• NCBI ID: WP_002899529.1
• Uniprot ID: -
• Organism: Streptococcus sanguinis strain NCTC7863
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2286498..2297262

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM63_RS11475 (NCTC7863_02266)	-	2286906..2288528 (+)	1623	WP_002899531.1	ATP-binding cassette domain-containing protein	-
DQM63_RS11480 (NCTC7863_02267)	-	2288604..2291189 (+)	2586	WP_002899530.1	YfhO family protein	-
DQM63_RS11495 (NCTC7863_02270)	comE	2291498..2292262 (-)	765	WP_002899529.1	competence system response regulator transcription factor ComE	Regulator
DQM63_RS11500 (NCTC7863_02271)	comD	2292268..2293602 (-)	1335	WP_002899527.1	competence system sensor histidine kinase ComD	-
DQM63_RS11505 (NCTC7863_02272)	-	2293630..2293737 (-)	108	WP_002894290.1	hypothetical protein	-
DQM63_RS11515 (NCTC7863_02274)	rlmH	2294034..2294513 (-)	480	WP_002899526.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQM63_RS11520 (NCTC7863_02275)	htrA	2294717..2295889 (+)	1173	WP_002899524.1	S1C family serine protease	Regulator
DQM63_RS11525 (NCTC7863_02276)	spo0J	2295953..2296714 (+)	762	WP_002899523.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 254 a.a.
• Molecular weight: 29879.14 Da
• Isoelectric Point: 8.0172

>NTDB_id=1139663 DQM63_RS11495 WP_002899529.1 2291498..2292262(-) (comE) [Streptococcus sanguinis strain NCTC7863]
MKVLVLEDTVSHQVRMETTLAEIAEELGIDIQVQVTGKIKEFKKYIENGDVNQLYFLDIDIKGEETKGLEVAQFIRHHNP
YAIIVFVTSKSEFATMTFKYKVSALDFIDKDINNDAFKNRIKDSILYTKSTLIENTNMVDYFEYSYRGNDVRMPYNDILY
IETTGSSHKLRIVGKNFLKEFYGTITDIQEKDQQSKRFFSPHKSYLVNIGNIVDYDKKNREIIFYENHRCPVTRLRVKYL
KDIFENRGKRVDKA

Nucleotide

• Length: 765 bp

>NTDB_id=1139663 DQM63_RS11495 WP_002899529.1 2291498..2292262(-) (comE) [Streptococcus sanguinis strain NCTC7863]
ATGAAAGTGTTAGTTTTAGAGGATACCGTATCTCATCAAGTCAGGATGGAAACGACATTAGCAGAAATTGCTGAGGAACT
TGGAATTGACATCCAGGTTCAGGTTACAGGAAAAATCAAAGAATTCAAAAAATATATTGAAAATGGAGACGTTAACCAGC
TTTATTTTTTGGATATTGACATTAAGGGGGAGGAAACAAAAGGGCTGGAAGTAGCTCAATTTATCCGTCATCATAATCCT
TATGCCATTATAGTTTTTGTAACCTCAAAATCTGAATTTGCTACTATGACTTTTAAATATAAAGTATCAGCACTTGATTT
TATCGATAAAGATATCAACAATGATGCTTTTAAAAATAGAATCAAAGACAGTATTCTTTACACTAAGAGTACACTAATTG
AAAATACCAATATGGTAGATTATTTTGAATATAGTTATCGTGGCAATGATGTTCGAATGCCTTATAACGATATTTTGTAT
ATCGAAACGACAGGGAGCTCTCATAAACTTCGGATTGTCGGTAAAAATTTTCTCAAGGAGTTTTATGGAACGATAACAGA
TATTCAAGAAAAAGATCAGCAATCTAAACGATTTTTTTCACCCCATAAATCTTATTTGGTTAATATTGGCAACATTGTTG
ATTATGACAAGAAAAATCGAGAAATTATTTTTTACGAAAATCATCGCTGTCCGGTCACTCGTTTAAGAGTGAAATATCTG
AAAGATATTTTCGAAAATAGAGGGAAAAGAGTTGACAAAGCTTAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-244)

• Response regulator receiver domain (Response_reg) (4-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus infantis strain Atu-4	68	98.425	0.669
comE/comE2	Streptococcus gordonii strain NCTC7865	68	98.425	0.669
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	68	98.425	0.669
comE	Streptococcus mitis NCTC 12261	67.6	98.425	0.665
comE	Streptococcus mitis SK321	66.8	98.425	0.657
comE	Streptococcus pneumoniae Rx1	66.4	98.425	0.654
comE	Streptococcus pneumoniae D39	66.4	98.425	0.654
comE	Streptococcus pneumoniae R6	66.4	98.425	0.654
comE	Streptococcus pneumoniae TIGR4	66.4	98.425	0.654
comE/blpR	Streptococcus mutans UA159	38.8	98.425	0.382