Detailed information NTG1139664

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: DQM63_RS11520
• Genome accession: NZ_LS483385
• Coordinates: 2294717..2295889 (+)
• Length: 390 a.a.
• NCBI ID: WP_002899524.1
• Uniprot ID: A0A428AHE2
• Organism: Streptococcus sanguinis strain NCTC7863
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2289717..2300889

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM63_RS11495 (NCTC7863_02270)	comE	2291498..2292262 (-)	765	WP_002899529.1	competence system response regulator transcription factor ComE	Regulator
DQM63_RS11500 (NCTC7863_02271)	comD	2292268..2293602 (-)	1335	WP_002899527.1	competence system sensor histidine kinase ComD	-
DQM63_RS11505 (NCTC7863_02272)	-	2293630..2293737 (-)	108	WP_002894290.1	hypothetical protein	-
DQM63_RS11515 (NCTC7863_02274)	rlmH	2294034..2294513 (-)	480	WP_002899526.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQM63_RS11520 (NCTC7863_02275)	htrA	2294717..2295889 (+)	1173	WP_002899524.1	S1C family serine protease	Regulator
DQM63_RS11525 (NCTC7863_02276)	spo0J	2295953..2296714 (+)	762	WP_002899523.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 390 a.a.
• Molecular weight: 40797.56 Da
• Isoelectric Point: 4.7432

>NTDB_id=1139664 DQM63_RS11520 WP_002899524.1 2294717..2295889(+) (htrA) [Streptococcus sanguinis strain NCTC7863]
MKNSSNAIKKALLLFAVLIVGFIGGSLGNYVTTLVTSRVKMNGNSTTSVATSYKNSTDISEAVKKVQNAVVSVITYAESS
SSVINDESSNDESQISSEGSGVIYKKDGKSAYLVTNTHVLNGSTNVDILLADGNKVPGEVVGSDVYSDISVVKISSEKVT
DVAEFGDSGSLTVGETAIAIGSPLGTEYANSVTQGIISSLGRNVTLQSENGENISTTALQTDAAINPGNSGGPLINIQGQ
VIGITSSKISTNGQTSVEGMGFAIPSNDVVNIINQLEKNGTVTRPALGIQMMDLSNLTTSDFSKLNLPSSVKSGILVRSV
QQGMPADGKLQKNDVITKVDNTDVESTSDLQSALYKHSIGDEVEITYYRDGKSQTVKIKLTKSTKELSSN

Nucleotide

• Length: 1173 bp

>NTDB_id=1139664 DQM63_RS11520 WP_002899524.1 2294717..2295889(+) (htrA) [Streptococcus sanguinis strain NCTC7863]
ATGAAAAACTCTTCAAATGCCATCAAAAAGGCTTTATTGCTTTTTGCAGTGTTAATTGTAGGTTTTATCGGCGGAAGTTT
AGGGAATTATGTTACTACATTAGTAACTTCACGTGTAAAAATGAATGGAAATTCAACAACTAGTGTAGCTACTTCATATA
AAAACTCTACAGACATTTCGGAAGCTGTGAAAAAGGTTCAAAATGCGGTTGTTTCAGTAATTACTTATGCTGAATCTTCT
AGTAGCGTTATTAATGATGAATCTTCCAACGATGAATCACAAATTTCCAGTGAAGGTTCTGGTGTAATTTATAAAAAAGA
CGGAAAGTCAGCCTATCTGGTAACCAACACCCACGTTCTTAACGGATCAACCAATGTAGATATCTTGCTAGCTGACGGAA
ACAAGGTTCCAGGTGAAGTAGTTGGATCAGATGTTTATTCAGATATTTCTGTCGTTAAAATTAGTTCTGAAAAAGTAACT
GATGTCGCTGAATTTGGAGATTCTGGTTCTCTGACAGTTGGTGAGACAGCTATCGCTATCGGAAGTCCTCTTGGAACAGA
ATATGCTAACTCTGTCACACAAGGAATTATTTCTAGTTTAGGTAGAAACGTTACGTTACAATCTGAAAATGGTGAAAATA
TTTCAACAACTGCACTGCAAACAGATGCTGCAATTAATCCTGGTAACTCTGGCGGCCCATTGATTAACATCCAAGGACAA
GTTATTGGGATTACTTCAAGTAAGATTTCAACAAATGGGCAAACCTCTGTTGAAGGGATGGGATTTGCGATTCCGTCTAA
TGATGTCGTAAATATTATCAATCAACTTGAGAAAAACGGAACAGTCACACGTCCTGCTTTAGGAATTCAAATGATGGATT
TATCTAATCTGACAACTTCTGATTTTTCTAAATTAAATCTTCCTTCTTCAGTGAAATCAGGTATTCTTGTTCGCTCTGTT
CAGCAAGGAATGCCTGCTGATGGCAAGCTTCAAAAAAATGATGTCATTACAAAAGTAGATAACACAGATGTGGAATCCAC
TAGTGATTTACAATCTGCTCTCTACAAGCATAGTATTGGAGATGAAGTAGAAATTACTTATTATCGAGATGGTAAATCTC
AAACAGTCAAAATCAAACTCACTAAATCAACAAAAGAGTTAAGCTCAAATTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (99-244)

• PDZ domain (PDZ_2) (285-380)

• Peptidase family M50 (Peptidase_M50) (231-385)

3D structure

• AlphaFold DB: A0A428AHE2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	67.424	100	0.685
htrA	Streptococcus mitis NCTC 12261	64.122	100	0.646
htrA	Streptococcus pneumoniae Rx1	64.122	100	0.646
htrA	Streptococcus pneumoniae D39	64.122	100	0.646
htrA	Streptococcus pneumoniae R6	64.122	100	0.646
htrA	Streptococcus pneumoniae TIGR4	64.122	100	0.646
htrA	Streptococcus mutans UA159	54.937	100	0.556