Detailed information NTG1136192

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: DQM44_RS02715
• Genome accession: NZ_LS483318
• Coordinates: 484502..485251 (+)
• Length: 249 a.a.
• NCBI ID: WP_002992578.1
• Uniprot ID: A0AAE9QYY6
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC5370
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 479502..490251

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM44_RS10585 (NCTC5370_00553)	-	480093..480398 (+)	306	Protein_479	NUDIX domain-containing protein	-
DQM44_RS02680	-	480376..482078 (-)	1703	Protein_480	ABC transporter transmembrane domain-containing protein	-
DQM44_RS02690 (NCTC5370_00556)	-	482380..482607 (+)	228	WP_022554332.1	Blp family class II bacteriocin	-
DQM44_RS02695 (NCTC5370_00557)	-	482656..482973 (+)	318	WP_002994587.1	hypothetical protein	-
DQM44_RS02700 (NCTC5370_00558)	-	483357..483620 (+)	264	WP_255306607.1	Blp family class II bacteriocin	-
DQM44_RS02705 (NCTC5370_00559)	-	483634..483819 (+)	186	WP_003054392.1	hypothetical protein	-
DQM44_RS02715 (NCTC5370_00561)	comE/blpR	484502..485251 (+)	750	WP_002992578.1	response regulator transcription factor	Regulator
DQM44_RS02720 (NCTC5370_00562)	-	485252..486586 (+)	1335	WP_014635339.1	GHKL domain-containing protein	-
DQM44_RS02725 (NCTC5370_00563)	-	486733..486858 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
DQM44_RS02730 (NCTC5370_00564)	-	486935..488299 (-)	1365	WP_046166193.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29191.55 Da
• Isoelectric Point: 5.8302

>NTDB_id=1136192 DQM44_RS02715 WP_002992578.1 484502..485251(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC5370]
MNIFVLEDDFLHQTRIEKIIYKILTDNKLEVNHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNRD
PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFINVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide

• Length: 750 bp

>NTDB_id=1136192 DQM44_RS02715 WP_002992578.1 484502..485251(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC5370]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACATCAAACCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTTGGAGGTTAACCACTTGGAAGTTTATGGTAAACCCAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAGAGAT
CCGCACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTATTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (150-239)

• Response regulator receiver domain (Response_reg) (3-119)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.508	97.992	0.534
comE/comE2	Streptococcus gordonii strain NCTC7865	40.873	100	0.414
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.873	100	0.414
comE/comE1	Streptococcus equinus JB1	42.017	95.582	0.402
comE/comE2	Streptococcus equinus JB1	40.574	97.992	0.398
comE	Streptococcus mitis NCTC 12261	38.8	100	0.39
comE	Streptococcus mitis SK321	38.8	100	0.39
comE	Streptococcus pneumoniae TIGR4	38.4	100	0.386
comE	Streptococcus pneumoniae Rx1	38.4	100	0.386
comE	Streptococcus pneumoniae D39	38.4	100	0.386
comE	Streptococcus pneumoniae R6	38.4	100	0.386
comE	Streptococcus infantis strain Atu-4	38.095	100	0.386