Detailed information NTG1127473

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: FGL12_RS01865
• Genome accession: NZ_LR594041
• Coordinates: 392086..392820 (+)
• Length: 244 a.a.
• NCBI ID: WP_011999888.1
• Uniprot ID: A8AV82
• Organism: Streptococcus gordonii strain NCTC9124
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 387086..397820

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL12_RS01845 (NCTC9124_00365)	-	387449..387799 (-)	351	WP_011999885.1	helix-turn-helix transcriptional regulator	-
FGL12_RS01850 (NCTC9124_00366)	-	388170..389795 (+)	1626	WP_138101118.1	malolactic enzyme	-
FGL12_RS01855 (NCTC9124_00367)	-	389872..390819 (+)	948	WP_011999887.1	AEC family transporter	-
FGL12_RS01860	-	391272..391463 (-)	192	Protein_358	site-specific integrase	-
FGL12_RS01865 (NCTC9124_00368)	comE/blpR	392086..392820 (+)	735	WP_011999888.1	LytTR family DNA-binding domain-containing protein	Regulator
FGL12_RS01870 (NCTC9124_00369)	-	392833..394170 (+)	1338	WP_049752449.1	GHKL domain-containing protein	-
FGL12_RS01875 (NCTC9124_00370)	-	394445..395125 (+)	681	WP_011999889.1	ABC transporter ATP-binding protein	-
FGL12_RS01880 (NCTC9124_00371)	-	395118..395837 (+)	720	WP_041789519.1	ABC transporter permease	-
FGL12_RS01885 (NCTC9124_00372)	-	396189..396392 (-)	204	WP_011999891.1	CsbD family protein	-
FGL12_RS01890 (NCTC9124_00373)	-	396574..397206 (-)	633	WP_164712039.1	DUF421 domain-containing protein	-
FGL12_RS01895 (NCTC9124_00374)	-	397203..397655 (-)	453	WP_011999893.1	DUF3290 family protein	-

Sequence

Protein

• Length: 244 a.a.
• Molecular weight: 28581.94 Da
• Isoelectric Point: 6.6147

>NTDB_id=1127473 FGL12_RS01865 WP_011999888.1 392086..392820(+) (comE/blpR) [Streptococcus gordonii strain NCTC9124]
MLNIYVLEDELLQQSRIETIIYKVIKDENLKINKFEIFGKPSQLLAEISERGAHQLFFLDIEIKDEEKKGLELAYQIRKL
DPNATIVFVTTHSEFMPLTFRYKVSALDFIDKALGDLHFYERVKSAIEYTLEKNGSTVAHDSFKFETSLSRVQVPFNKIL
YFETSPTVHKVIMHTVDERLEFYAGISEIEKSDNRLYRCHKSFVVNPENISKIDKENRLILFENGESCLVSKTKLKKLKE
RLDF

Nucleotide

• Length: 735 bp

>NTDB_id=1127473 FGL12_RS01865 WP_011999888.1 392086..392820(+) (comE/blpR) [Streptococcus gordonii strain NCTC9124]
ATGCTTAACATTTATGTTTTGGAAGACGAATTACTACAGCAGTCTCGCATAGAGACTATTATTTATAAGGTTATAAAAGA
TGAAAATTTAAAAATTAATAAGTTTGAGATTTTTGGAAAGCCATCTCAATTATTAGCAGAGATAAGTGAGAGAGGGGCTC
ATCAGTTATTTTTTTTAGATATTGAGATCAAGGATGAAGAAAAAAAAGGATTAGAGCTTGCTTATCAAATTAGAAAACTC
GATCCCAATGCAACTATTGTCTTTGTGACTACTCATTCTGAGTTTATGCCATTAACATTTAGATATAAAGTTAGTGCTTT
GGATTTTATTGATAAGGCACTTGGTGATCTTCATTTTTATGAAAGAGTAAAATCAGCGATTGAATATACATTGGAAAAAA
ATGGAAGTACTGTTGCTCATGATTCTTTTAAATTCGAAACATCACTATCTCGTGTTCAAGTTCCATTTAATAAAATTCTT
TATTTCGAAACATCGCCTACTGTGCATAAGGTTATTATGCATACGGTAGATGAAAGATTAGAATTTTATGCTGGAATTTC
TGAGATTGAAAAATCGGATAATAGGTTATACAGATGTCACAAGTCATTTGTCGTAAATCCTGAAAACATTAGTAAGATTG
ATAAGGAAAATAGGCTAATTCTATTTGAAAATGGAGAAAGTTGCTTAGTTTCTAAAACTAAATTAAAGAAACTCAAGGAA
AGGTTAGATTTTTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-118)

• LytTr DNA-binding domain (LytTR) (152-242)

3D structure

• AlphaFold DB: A8AV82

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	56.198	99.18	0.557
comE/comE1	Streptococcus equinus JB1	46.218	97.541	0.451
comE/comE2	Streptococcus gordonii strain NCTC7865	40.891	100	0.414
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.891	100	0.414
comE/comE2	Streptococcus equinus JB1	38.683	99.59	0.385
comE	Streptococcus mitis NCTC 12261	37.903	100	0.385
comE	Streptococcus pneumoniae D39	37.903	100	0.385
comE	Streptococcus pneumoniae Rx1	37.903	100	0.385
comE	Streptococcus pneumoniae R6	37.903	100	0.385
comE	Streptococcus pneumoniae TIGR4	37.903	100	0.385
comE	Streptococcus mitis SK321	37.903	100	0.385
comE	Streptococcus infantis strain Atu-4	36.29	100	0.369