Detailed information NTG1127234

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: FGL00_RS02615
• Genome accession: NZ_LR594034
• Coordinates: 493843..494592 (+)
• Length: 249 a.a.
• NCBI ID: WP_065358564.1
• Uniprot ID: -
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	492503..498469	493843..494592	within	0

Gene organization within MGE regions

Location: 492503..498469

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL00_RS02610 (NCTC8546_00538)	-	492503..493636 (+)	1134	WP_022554244.1	ISAs1-like element IS1548 family transposase	-
FGL00_RS02615 (NCTC8546_00539)	comE/blpR	493843..494592 (+)	750	WP_065358564.1	response regulator transcription factor	Regulator
FGL00_RS02620 (NCTC8546_00540)	-	494593..495927 (+)	1335	WP_065358565.1	GHKL domain-containing protein	-
FGL00_RS02625 (NCTC8546_00541)	-	496075..496200 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
FGL00_RS02630 (NCTC8546_00542)	-	496277..497383 (-)	1107	WP_343233178.1	bacteriocin secretion accessory protein	-
FGL00_RS02635 (NCTC8546_00543)	-	497441..498463 (-)	1023	WP_172600594.1	IS30 family transposase	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29225.56 Da
• Isoelectric Point: 5.6520

>NTDB_id=1127234 FGL00_RS02615 WP_065358564.1 493843..494592(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546]
MNIFILEDDFLQQSRIEKIIYKILTDNKWEINHLGVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNRD
PYAVIVFVTTHSEFMPVSFQYQLSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFTNVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide

• Length: 750 bp

>NTDB_id=1127234 FGL00_RS02615 WP_065358564.1 493843..494592(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546]
ATGAATATTTTTATTTTGGAAGATGATTTTTTACAACAAAGTAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTGGGAGATTAACCACTTGGGAGTTTATGGTAAACCTAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAGATTGCTGTGGAGATTAGAAATAGAGAT
CCGTACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTGTCTTTTCAATACCAGCTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (150-239)

• Response regulator receiver domain (Response_reg) (3-119)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.508	97.992	0.534
comE/comE1	Streptococcus equinus JB1	42.437	95.582	0.406
comE/comE2	Streptococcus gordonii strain NCTC7865	40.079	100	0.406
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.079	100	0.406
comE/comE2	Streptococcus equinus JB1	40.574	97.992	0.398
comE	Streptococcus mitis NCTC 12261	39.2	100	0.394
comE	Streptococcus mitis SK321	39.2	100	0.394
comE	Streptococcus pneumoniae TIGR4	38.8	100	0.39
comE	Streptococcus pneumoniae Rx1	38.8	100	0.39
comE	Streptococcus pneumoniae D39	38.8	100	0.39
comE	Streptococcus pneumoniae R6	38.8	100	0.39
comE	Streptococcus infantis strain Atu-4	38.71	99.598	0.386