Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   FGL00_RS02615 Genome accession   NZ_LR594034
Coordinates   493843..494592 (+) Length   249 a.a.
NCBI ID   WP_065358564.1    Uniprot ID   -
Organism   Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 488843..499592
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL00_RS02585 (NCTC8546_00533) - 490395..490622 (+) 228 WP_022554332.1 Blp family class II bacteriocin -
  FGL00_RS02590 (NCTC8546_00534) - 490671..490988 (+) 318 WP_002994587.1 hypothetical protein -
  FGL00_RS02595 (NCTC8546_00535) - 491372..491635 (+) 264 WP_255306607.1 Blp family class II bacteriocin -
  FGL00_RS02600 (NCTC8546_00536) - 491649..491834 (+) 186 WP_003054392.1 hypothetical protein -
  FGL00_RS02605 (NCTC8546_00537) - 492087..492320 (+) 234 WP_065358913.1 hypothetical protein -
  FGL00_RS02610 (NCTC8546_00538) - 492503..493636 (+) 1134 WP_022554244.1 ISAs1-like element IS1548 family transposase -
  FGL00_RS02615 (NCTC8546_00539) comE/blpR 493843..494592 (+) 750 WP_065358564.1 response regulator transcription factor Regulator
  FGL00_RS02620 (NCTC8546_00540) - 494593..495927 (+) 1335 WP_065358565.1 GHKL domain-containing protein -
  FGL00_RS02625 (NCTC8546_00541) - 496075..496200 (-) 126 WP_011017462.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  FGL00_RS02630 (NCTC8546_00542) - 496277..497383 (-) 1107 WP_343233178.1 bacteriocin secretion accessory protein -
  FGL00_RS02635 (NCTC8546_00543) - 497441..498463 (-) 1023 WP_172600594.1 IS30 family transposase -
  FGL00_RS02640 (NCTC8546_00544) - 498552..498818 (-) 267 Protein_459 bacteriocin ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29225.56 Da        Isoelectric Point: 5.6520

>NTDB_id=1127234 FGL00_RS02615 WP_065358564.1 493843..494592(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546]
MNIFILEDDFLQQSRIEKIIYKILTDNKWEINHLGVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNRD
PYAVIVFVTTHSEFMPVSFQYQLSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFTNVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide


Download         Length: 750 bp        

>NTDB_id=1127234 FGL00_RS02615 WP_065358564.1 493843..494592(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546]
ATGAATATTTTTATTTTGGAAGATGATTTTTTACAACAAAGTAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTGGGAGATTAACCACTTGGGAGTTTATGGTAAACCTAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAGATTGCTGTGGAGATTAGAAATAGAGAT
CCGTACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTGTCTTTTCAATACCAGCTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterProScan.

LytTr DNA-binding domain (LytTR)

(150-239)

Response regulator receiver domain (Response_reg)

(3-119)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.508

97.992

0.534
  comE/comE1 Streptococcus equinus JB1

42.437

95.582

0.406
  comE/comE2 Streptococcus gordonii strain NCTC7865

40.079

100

0.406
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

40.079

100

0.406
  comE/comE2 Streptococcus equinus JB1

40.574

97.992

0.398
  comE Streptococcus mitis NCTC 12261

39.2

100

0.394
  comE Streptococcus mitis SK321

39.2

100

0.394
  comE Streptococcus pneumoniae TIGR4

38.8

100

0.39
  comE Streptococcus pneumoniae Rx1

38.8

100

0.39
  comE Streptococcus pneumoniae D39

38.8

100

0.39
  comE Streptococcus pneumoniae R6

38.8

100

0.39
  comE Streptococcus infantis strain Atu-4

38.71

99.598

0.386

Multiple sequence alignment