Detailed information NTG0106479

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: AABA19_RS10835
• Genome accession: NZ_AP028609
• Coordinates: 2113033..2113785 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain Sep4
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2108033..2118785

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AABA19_RS10815	-	2110467..2112069 (-)	1603	Protein_2094	YhgE/Pip family protein	-
AABA19_RS10820 (TKY121806_20970)	-	2112248..2112790 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
AABA19_RS10835 (TKY121806_20980)	comE	2113033..2113785 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
AABA19_RS10840 (TKY121806_20990)	comD/comD1	2113782..2115107 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
AABA19_RS10845 (TKY121806_21000)	comC/comC1	2115128..2115253 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
AABA19_RS10855 (TKY121806_21010)	rlmH	2115535..2116014 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
AABA19_RS10860 (TKY121806_21020)	htrA	2116197..2117378 (+)	1182	WP_338170950.1	S1C family serine protease	Regulator
AABA19_RS10865 (TKY121806_21030)	spo0J	2117436..2118194 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=106479 AABA19_RS10835 WP_000866065.1 2113033..2113785(-) (comE) [Streptococcus pneumoniae strain Sep4]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=106479 AABA19_RS10835 WP_000866065.1 2113033..2113785(-) (comE) [Streptococcus pneumoniae strain Sep4]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACATATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408