Detailed information NTG0106482

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: AABA19_RS10860
• Genome accession: NZ_AP028609
• Coordinates: 2116197..2117378 (+)
• Length: 393 a.a.
• NCBI ID: WP_338170950.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain Sep4
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2111197..2122378

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AABA19_RS10820 (TKY121806_20970)	-	2112248..2112790 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
AABA19_RS10835 (TKY121806_20980)	comE	2113033..2113785 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
AABA19_RS10840 (TKY121806_20990)	comD/comD1	2113782..2115107 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
AABA19_RS10845 (TKY121806_21000)	comC/comC1	2115128..2115253 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
AABA19_RS10855 (TKY121806_21010)	rlmH	2115535..2116014 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
AABA19_RS10860 (TKY121806_21020)	htrA	2116197..2117378 (+)	1182	WP_338170950.1	S1C family serine protease	Regulator
AABA19_RS10865 (TKY121806_21030)	spo0J	2117436..2118194 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41811.69 Da
• Isoelectric Point: 6.8902

>NTDB_id=106482 AABA19_RS10860 WP_338170950.1 2116197..2117378(+) (htrA) [Streptococcus pneumoniae strain Sep4]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSGVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVI
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=106482 AABA19_RS10860 WP_338170950.1 2116197..2117378(+) (htrA) [Streptococcus pneumoniae strain Sep4]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTGGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAATT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (289-384)

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	99.746	100	0.997
htrA	Streptococcus pneumoniae D39	99.746	100	0.997
htrA	Streptococcus pneumoniae R6	99.746	100	0.997
htrA	Streptococcus pneumoniae TIGR4	99.746	100	0.997
htrA	Streptococcus mitis NCTC 12261	97.201	100	0.972
htrA	Streptococcus gordonii str. Challis substr. CH1	66.414	100	0.669
htrA	Streptococcus mutans UA159	54.315	100	0.545