Detailed information NTG1043543

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ACD269_RS10930
• Genome accession: NZ_CP168260
• Coordinates: 2123346..2124098 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain FC2
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2118346..2129098

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACD269_RS10910 (ACD269_10910)	-	2120779..2122382 (-)	1604	Protein_2111	YhgE/Pip family protein	-
ACD269_RS10915 (ACD269_10915)	-	2122561..2123103 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
ACD269_RS10930 (ACD269_10930)	comE	2123346..2124098 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
ACD269_RS10935 (ACD269_10935)	comD/comD1	2124095..2125420 (-)	1326	WP_015898772.1	competence system sensor histidine kinase ComD	Regulator
ACD269_RS10940 (ACD269_10940)	comC/comC1	2125441..2125566 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
ACD269_RS10950 (ACD269_10950)	rlmH	2125849..2126328 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACD269_RS10955 (ACD269_10955)	htrA	2126511..2127692 (+)	1182	WP_373380559.1	S1C family serine protease	Regulator
ACD269_RS10960 (ACD269_10960)	spo0J	2127750..2128508 (+)	759	WP_000410384.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=1043543 ACD269_RS10930 WP_000866065.1 2123346..2124098(-) (comE) [Streptococcus pneumoniae strain FC2]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=1043543 ACD269_RS10930 WP_000866065.1 2123346..2124098(-) (comE) [Streptococcus pneumoniae strain FC2]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAAC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408