Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   ACD269_RS10955 Genome accession   NZ_CP168260
Coordinates   2126511..2127692 (+) Length   393 a.a.
NCBI ID   WP_373380559.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain FC2     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 2121511..2132692
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACD269_RS10915 (ACD269_10915) - 2122561..2123103 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  ACD269_RS10930 (ACD269_10930) comE 2123346..2124098 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  ACD269_RS10935 (ACD269_10935) comD/comD1 2124095..2125420 (-) 1326 WP_015898772.1 competence system sensor histidine kinase ComD Regulator
  ACD269_RS10940 (ACD269_10940) comC/comC1 2125441..2125566 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  ACD269_RS10950 (ACD269_10950) rlmH 2125849..2126328 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ACD269_RS10955 (ACD269_10955) htrA 2126511..2127692 (+) 1182 WP_373380559.1 S1C family serine protease Regulator
  ACD269_RS10960 (ACD269_10960) spo0J 2127750..2128508 (+) 759 WP_000410384.1 ParB/RepB/Spo0J family partition protein Regulator
  ACD269_RS10965 (ACD269_10965) - 2128721..2129683 (+) 963 WP_011117663.1 protein rep -
  ACD269_RS10970 (ACD269_10970) - 2130604..2131080 (+) 477 WP_050201876.1 hypothetical protein -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41854.76 Da        Isoelectric Point: 7.3927

>NTDB_id=1043546 ACD269_RS10955 WP_373380559.1 2126511..2127692(+) (htrA) [Streptococcus pneumoniae strain FC2]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVKTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=1043546 ACD269_RS10955 WP_373380559.1 2126511..2127692(+) (htrA) [Streptococcus pneumoniae strain FC2]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGGGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTAAAAATCTCTTCA
GAAAAAGTGAAAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTGA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

99.491

100

0.995
  htrA Streptococcus pneumoniae D39

99.491

100

0.995
  htrA Streptococcus pneumoniae R6

99.491

100

0.995
  htrA Streptococcus pneumoniae TIGR4

99.491

100

0.995
  htrA Streptococcus mitis NCTC 12261

97.201

100

0.972
  htrA Streptococcus gordonii str. Challis substr. CH1

66.919

100

0.674
  htrA Streptococcus mutans UA159

54.569

100

0.547

Multiple sequence alignment