Detailed information NTG1018104

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: DQL28_RS07280
• Genome accession: NZ_LS483334
• Coordinates: 1438427..1439176 (-)
• Length: 249 a.a.
• NCBI ID: WP_030126108.1
• Uniprot ID: A0A223M029
• Organism: Streptococcus pyogenes strain NCTC12050
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1433427..1444176

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL28_RS07265 (NCTC12050_01446)	-	1435378..1436742 (+)	1365	WP_111676664.1	bacteriocin secretion accessory protein	-
DQL28_RS07270 (NCTC12050_01447)	-	1436819..1436944 (+)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
DQL28_RS07275 (NCTC12050_01448)	-	1437092..1438426 (-)	1335	WP_080147975.1	sensor histidine kinase	-
DQL28_RS07280 (NCTC12050_01449)	comE/blpR	1438427..1439176 (-)	750	WP_030126108.1	response regulator transcription factor	Regulator
DQL28_RS07285	-	1439412..1440900 (-)	1489	Protein_1362	IS1182 family transposase	-
DQL28_RS07290 (NCTC12050_01452)	-	1441114..1442198 (-)	1085	Protein_1363	IS3 family transposase	-
DQL28_RS07300 (NCTC12050_01453)	-	1442318..1442635 (-)	318	WP_002994587.1	hypothetical protein	-
DQL28_RS07305 (NCTC12050_01454)	-	1442684..1442899 (-)	216	WP_109991843.1	Blp family class II bacteriocin	-
DQL28_RS09645	-	1443296..1443424 (-)	129	WP_002994583.1	hypothetical protein	-
DQL28_RS09740	-	1443509..1443820 (-)	312	WP_227868558.1	CPBP family intramembrane glutamic endopeptidase	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29141.44 Da
• Isoelectric Point: 5.8302

>NTDB_id=1018104 DQL28_RS07280 WP_030126108.1 1438427..1439176(-) (comE/blpR) [Streptococcus pyogenes strain NCTC12050]
MNIFVLEDDFLHQTRIEKIIYKILTDNKLEVNHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNKD
PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFTNVKSQIQVSFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide

• Length: 750 bp

>NTDB_id=1018104 DQL28_RS07280 WP_030126108.1 1438427..1439176(-) (comE/blpR) [Streptococcus pyogenes strain NCTC12050]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACATCAAACCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTTGGAGGTTAACCACTTGGAAGTTTATGGTAAACCCAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAAAGAT
CCGCACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCTCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTCAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (150-239)

• Response regulator receiver domain (Response_reg) (3-119)

3D structure

• AlphaFold DB: A0A223M029

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.098	97.992	0.53
comE/comE2	Streptococcus gordonii strain NCTC7865	40.476	100	0.41
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.476	100	0.41
comE/comE1	Streptococcus equinus JB1	42.437	95.582	0.406
comE/comE2	Streptococcus equinus JB1	40.574	97.992	0.398
comE	Streptococcus mitis NCTC 12261	38.4	100	0.386
comE	Streptococcus mitis SK321	38.4	100	0.386
comE	Streptococcus pneumoniae TIGR4	38	100	0.382
comE	Streptococcus pneumoniae Rx1	38	100	0.382
comE	Streptococcus pneumoniae D39	38	100	0.382
comE	Streptococcus pneumoniae R6	38	100	0.382
comE	Streptococcus infantis strain Atu-4	37.903	99.598	0.378