Detailed information NTG1017147

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: DQL05_RS06790
• Genome accession: NZ_LS483322
• Coordinates: 1338876..1339625 (-)
• Length: 249 a.a.
• NCBI ID: WP_111692046.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC12066
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1333876..1344625

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL05_RS06775 (NCTC12066_01346)	-	1335826..1337191 (+)	1366	Protein_1252	bacteriocin secretion accessory protein	-
DQL05_RS06780 (NCTC12066_01347)	-	1337268..1337393 (+)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
DQL05_RS06785 (NCTC12066_01348)	-	1337541..1338875 (-)	1335	WP_014635339.1	sensor histidine kinase	-
DQL05_RS06790 (NCTC12066_01349)	comE/blpR	1338876..1339625 (-)	750	WP_111692046.1	response regulator transcription factor	Regulator
DQL05_RS06795	-	1339860..1341354 (-)	1495	Protein_1256	IS1182 family transposase	-
DQL05_RS09035	-	1341568..1342652 (-)	1085	Protein_1257	IS3 family transposase	-
DQL05_RS06815 (NCTC12066_01354)	-	1342772..1343089 (-)	318	WP_002994587.1	hypothetical protein	-
DQL05_RS06820 (NCTC12066_01355)	-	1343138..1343365 (-)	228	WP_028797129.1	Blp family class II bacteriocin	-
DQL05_RS09130	-	1343763..1343891 (-)	129	WP_002994583.1	hypothetical protein	-
DQL05_RS09235	-	1343976..1344287 (-)	312	WP_227868852.1	CPBP family intramembrane glutamic endopeptidase	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29163.49 Da
• Isoelectric Point: 5.8302

>NTDB_id=1017147 DQL05_RS06790 WP_111692046.1 1338876..1339625(-) (comE/blpR) [Streptococcus pyogenes strain NCTC12066]
MNIFVLEDDFLHQTRIEKIIYKILTDNKLEVNHLEVYGKPNQLLEDISERGRHQLFFLDIDTKGEDKKGMEIAVEIRNRD
PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFINVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRAERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide

• Length: 750 bp

>NTDB_id=1017147 DQL05_RS06790 WP_111692046.1 1338876..1339625(-) (comE/blpR) [Streptococcus pyogenes strain NCTC12066]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACATCAAACCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTTGGAGGTTAACCACTTGGAAGTTTATGGTAAACCCAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACACTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAGAGAT
CCGCACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTATTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GAGCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (3-119)

• LytTr DNA-binding domain (LytTR) (150-239)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.098	97.992	0.53
comE/comE2	Streptococcus gordonii strain NCTC7865	40.476	100	0.41
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.476	100	0.41
comE/comE2	Streptococcus equinus JB1	40.164	97.992	0.394
comE/comE1	Streptococcus equinus JB1	41.176	95.582	0.394
comE	Streptococcus mitis SK321	38.4	100	0.386
comE	Streptococcus mitis NCTC 12261	38.4	100	0.386
comE	Streptococcus pneumoniae TIGR4	38	100	0.382
comE	Streptococcus pneumoniae Rx1	38	100	0.382
comE	Streptococcus pneumoniae D39	38	100	0.382
comE	Streptococcus pneumoniae R6	38	100	0.382
comE	Streptococcus infantis strain Atu-4	37.698	100	0.382