Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/AbrB-MazF |
| Location | 170983..171554 | Replicon | chromosome |
| Accession | NC_004350 | ||
| Organism | Streptococcus mutans UA159 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | Q8DW95 |
| Locus tag | SMU_RS00860 | Protein ID | WP_002262989.1 |
| Coordinates | 171222..171554 (+) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | Q8DW96 |
| Locus tag | SMU_RS00855 | Protein ID | WP_002262990.1 |
| Coordinates | 170983..171228 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SMU_RS00820 (SMU.164) | 166491..167237 | + | 747 | WP_002262998.1 | 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB | - |
| SMU_RS00825 (SMU.165) | 167261..168121 | + | 861 | WP_002262997.1 | DegV family protein | - |
| SMU_RS00830 (SMU.166) | 168253..168768 | + | 516 | WP_002262996.1 | hypothetical protein | - |
| SMU_RS00835 (SMU.167) | 168768..169214 | + | 447 | WP_002262995.1 | hypothetical protein | - |
| SMU_RS00840 (SMU.168) | 169211..169405 | + | 195 | WP_002262994.1 | helix-turn-helix transcriptional regulator | - |
| SMU_RS00845 (SMU.169) | 169798..170244 | + | 447 | WP_002262993.1 | 50S ribosomal protein L13 | - |
| SMU_RS00850 (SMU.170) | 170269..170661 | + | 393 | WP_002262992.1 | 30S ribosomal protein S9 | - |
| SMU_RS00855 (SMU.172) | 170983..171228 | + | 246 | WP_002262990.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| SMU_RS00860 (SMU.173) | 171222..171554 | + | 333 | WP_002262989.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| SMU_RS00865 (SMU.174c) | 171752..172543 | - | 792 | WP_002262988.1 | DUF4037 domain-containing protein | - |
| SMU_RS00870 | 172710..173063 | + | 354 | Protein_151 | transposase family protein | - |
| SMU_RS00875 (SMU.177) | 173245..174465 | + | 1221 | WP_002262024.1 | PTS sugar transporter subunit IIC | - |
| SMU_RS00880 (SMU.178) | 174443..175291 | + | 849 | WP_002262025.1 | alpha/beta hydrolase | - |
| SMU_RS00885 (SMU.179) | 175433..176035 | + | 603 | WP_002262026.1 | NAD(P)H-dependent oxidoreductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| flank | IS/Tn | - | - | 172710..172838 | 128 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 12640.50 Da Isoelectric Point: 6.4634
>T663 WP_002262989.1 NC_004350:171222-171554 [Streptococcus mutans UA159]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIGIFAPISNTKRDYPFYVSLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIGIFAPISNTKRDYPFYVSLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG
Download Length: 333 bp
>T663 NC_004350:171222-171554 [Streptococcus mutans UA159]
ATGGTAACCATCAAGCAAGGGTCAATTATCAAAATTAACTTGGATCCCAAACAAGGACATGAACAAAAAGGGTATCGTCC
GTACATTTGTCTAAACCATAGTATCGTAACCAAGTATTCTAATATTGGTATTTTTGCGCCAATTAGCAATACCAAGCGTG
ATTATCCTTTTTATGTTTCCCTAGAAGGAACAGAATCCACAGGGAAAGTATTATTAGACCAACTGGTTACAATCGATTTT
AATGCTAGAGATTATCGTTATGTGGAGGATATTCAGGAAGACTTATTAGATGAACTTTTAGCTAGGGTCAAGGTGCTATT
TGAAAAAGGATAA
ATGGTAACCATCAAGCAAGGGTCAATTATCAAAATTAACTTGGATCCCAAACAAGGACATGAACAAAAAGGGTATCGTCC
GTACATTTGTCTAAACCATAGTATCGTAACCAAGTATTCTAATATTGGTATTTTTGCGCCAATTAGCAATACCAAGCGTG
ATTATCCTTTTTATGTTTCCCTAGAAGGAACAGAATCCACAGGGAAAGTATTATTAGACCAACTGGTTACAATCGATTTT
AATGCTAGAGATTATCGTTATGTGGAGGATATTCAGGAAGACTTATTAGATGAACTTTTAGCTAGGGTCAAGGTGCTATT
TGAAAAAGGATAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9241.52 Da Isoelectric Point: 4.3021
>AT663 WP_002262990.1 NC_004350:170983-171228 [Streptococcus mutans UA159]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNIPELTVEDLFKDYQGEPVNVTPALFESVGNEQ
W
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNIPELTVEDLFKDYQGEPVNVTPALFESVGNEQ
W
Download Length: 246 bp
>AT663 NC_004350:170983-171228 [Streptococcus mutans UA159]
ATGCAACTAGTCATCAATAAATGGGGAAATAGCTCCGCTATTCGTTTGCCAAAACAATTGGTACAAGAATTACAATTACA
AACAAATGATGTCTTAGACTATAAGGTATCAGGGAATAAAATTATCCTAGAAAAAGTGAATAATATCCCTGAATTAACTG
TAGAAGATCTGTTTAAAGATTATCAAGGTGAACCTGTCAATGTTACCCCAGCTCTATTTGAAAGTGTGGGAAATGAACAA
TGGTAA
ATGCAACTAGTCATCAATAAATGGGGAAATAGCTCCGCTATTCGTTTGCCAAAACAATTGGTACAAGAATTACAATTACA
AACAAATGATGTCTTAGACTATAAGGTATCAGGGAATAAAATTATCCTAGAAAAAGTGAATAATATCCCTGAATTAACTG
TAGAAGATCTGTTTAAAGATTATCAAGGTGAACCTGTCAATGTTACCCCAGCTCTATTTGAAAGTGTGGGAAATGAACAA
TGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T1852 | Lactobacillus salivarius UCC118 |
39.815 |
98.182 |
0.391 |
| T1076 | Shigella flexneri 2b |
32.11 |
99.091 |
0.318 |
| T6120 | Xylella fastidiosa |
31.481 |
100 |
0.315 |
| T1049 | Escherichia coli str. K-12 substr. MG1655 |
30.357 |
100 |
0.309 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT652 | Leptospira interrogans serovar Lai str. 56601 |
36.62 |
93.421 |
0.342 |
Multiple sequence alignment
References
(1) Mohammad Adnan Syed et al. (2011) The chromosomal mazEF locus of Streptococcus mutans encodes a functional type II toxin-antitoxin addiction system. Journal of Bacteriology 193(5):1122-30. [PubMed:21183668]
(2) Xiao-Lin Tian et al. (2019) ClpP is required for proteolytic regulation of type II toxin-antitoxin systems and persister cell formation in Streptococcus mutans. Access Microbiology 1(8):e000054. [PubMed:32974554]