Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1727657..1728228 Replicon chromosome
Accession NZ_CP050270
Organism Streptococcus mutans strain S4

Toxin (Protein)


Gene name mazF Uniprot ID Q8DW95
Locus tag HB753_RS08475 Protein ID WP_002262989.1
Coordinates 1727657..1727989 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HB753_RS08480 Protein ID WP_019315031.1
Coordinates 1727983..1728228 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB753_RS08450 1723176..1723778 - 603 WP_002271857.1 NAD(P)H-dependent oxidoreductase -
HB753_RS08455 1723920..1724768 - 849 WP_002265112.1 alpha/beta hydrolase -
HB753_RS08460 1724746..1725966 - 1221 WP_002267692.1 PTS sugar transporter subunit IIC -
HB753_RS08465 1726148..1726501 - 354 Protein_1642 transposase family protein -
HB753_RS08470 1726668..1727459 + 792 WP_025985815.1 DUF4037 domain-containing protein -
HB753_RS08475 1727657..1727989 - 333 WP_002262989.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HB753_RS08480 1727983..1728228 - 246 WP_019315031.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HB753_RS08485 1728831..1729202 - 372 WP_049473463.1 type II toxin-antitoxin system death-on-curing family toxin -
HB753_RS08490 1729199..1729456 - 258 WP_049473464.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HB753_RS08495 1729578..1731416 - 1839 Protein_1648 hypothetical protein -
HB753_RS08500 1731685..1732710 - 1026 WP_080351607.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1722506..1758689 36183
flank IS/Tn - - 1726373..1726501 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

Antitoxin PemI-like

(1-81)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12640.50 Da        Isoelectric Point: 6.4634

>T152451 WP_002262989.1 NZ_CP050270:c1727989-1727657 [Streptococcus mutans]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIGIFAPISNTKRDYPFYVSLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Download         Length: 333 bp

>T152451 NZ_CP066167:c3992203-3991919 [Spongiibacter sp. CSC3.9]
ATGACCTATAAGCTCCGTTTTCTCCCCGCTGCACTGAAGGAATGGAACAAGCTTGGAGCTCCGATACGTAGCCAGTTTAA
AAAGAAACTCGCAGAAAGATTGAATGAGCCGAGAGTGCAGGCAGATAAATTGAGCGGCTATGAATCGGTATATAAAATCA
AACTTAGGTCGGCTGGTTACAGGTTGGCATACGAGGTTGTAGACGACGAGCTGCTTGTTTACGTTCTCGCTATTGGTAAA
CGAGAGAAAGGTAAAATTTATTCGTCACTTAAAAAGCGAACTTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9241.52 Da        Isoelectric Point: 4.3021

>AT152451 WP_019315031.1 NZ_CP050270:c1728228-1727983 [Streptococcus mutans]
MQLVINKWGNSSAVRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNVPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W

Download         Length: 246 bp

>AT152451 NZ_CP066167:c3992444-3992193 [Spongiibacter sp. CSC3.9]
ATGCGACAGGTTTTAGCCGACTTCTCTGTAAGTATCTCAGAACTAAAGAAAAATCCTTCTTCTTTGCTCTCTCAGGCAAG
TGGTTCTCCTATTGCTGTTCTGAACCACAACAAGCCCGCTGCGTATTTGATTCCGGCAGAAACCTACGAAGCTCTGATGG
ACATGATTGAGGATTATGAACTCTCAAAGTTGGTGGAGGAGCGTCGTGGTGACAAGGAGCAGGCTATAGCGGTGTCCTTG
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8DW95

Antitoxin

Source ID Structure

References