10164

Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) SmuAT/-
Location 168253..169405 Replicon chromosome
Accession NC_004350
Organism Streptococcus mutans UA159

Toxin (Protein)


Gene name smuT Uniprot ID Q8DWA1
Locus tag SMU_RS00830 Protein ID WP_002262996.1
Coordinates 168253..168768 (+) Length 172 a.a.

Antitoxin (Protein)


Gene name smuA Uniprot ID Q8DWA0
Locus tag SMU_RS00835 Protein ID WP_002262995.1
Coordinates 168768..169214 (+) Length 149 a.a.

Regulator (Protein)


Gene name smuR Uniprot ID Q8DW99
Locus tag SMU_RS00840 Protein ID WP_002262994.1
Coordinates 169211..169405 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMU_RS00805 (SMU.161) 163670..164407 + 738 WP_002263001.1 MerR family transcriptional regulator -
SMU_RS00810 (SMU.162c) 164443..165435 - 993 WP_002263000.1 BtrH N-terminal domain-containing protein -
SMU_RS00815 (SMU.163c) 165624..166178 - 555 WP_002262999.1 PadR family transcriptional regulator -
SMU_RS00820 (SMU.164) 166491..167237 + 747 WP_002262998.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
SMU_RS00825 (SMU.165) 167261..168121 + 861 WP_002262997.1 DegV family protein -
SMU_RS00830 (SMU.166) 168253..168768 + 516 WP_002262996.1 hypothetical protein Toxin
SMU_RS00835 (SMU.167) 168768..169214 + 447 WP_002262995.1 hypothetical protein Antitoxin
SMU_RS00840 (SMU.168) 169211..169405 + 195 WP_002262994.1 helix-turn-helix transcriptional regulator Regulator
SMU_RS00845 (SMU.169) 169798..170244 + 447 WP_002262993.1 50S ribosomal protein L13 -
SMU_RS00850 (SMU.170) 170269..170661 + 393 WP_002262992.1 30S ribosomal protein S9 -
SMU_RS00855 (SMU.172) 170983..171228 + 246 WP_002262990.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
SMU_RS00860 (SMU.173) 171222..171554 + 333 WP_002262989.1 type II toxin-antitoxin system PemK/MazF family toxin -
SMU_RS00865 (SMU.174c) 171752..172543 - 792 WP_002262988.1 DUF4037 domain-containing protein -
SMU_RS00870 172710..173063 + 354 Protein_151 transposase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 172710..172838 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 172 a.a.        Molecular weight: 19398.99 Da        Isoelectric Point: 9.7364

>T10164 WP_002262996.1 NC_004350:168253-168768 [Streptococcus mutans UA159]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTAGKNKKFLYVYAVIIAVQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK

Download         Length: 516 bp

>T10164 NC_004350:168253-168768 [Streptococcus mutans UA159]
ATGTTTGACCTTGTTGTTAATTTGATTTTATTGGTTATTGTGATAGGTGGATTTGTCTTCTTAAGATTCTATGCGGATAA
GAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGG
GTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTC
TTTCTTATCGTAGGCGTCTTTGTCTGCAGCAGTATCTTAAACGATGCTTATTTCACAGCAGGAAAAAACAAAAAATTCCT
CTATGTGTATGCCGTTATTATTGCTGTTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACG
GACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGCTGTCATTTTTCTAGTAACTGCT
TATAAAACGATTCAGGATAAGAGAGAGGGAAAGTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16968.23 Da        Isoelectric Point: 9.5767

>AT10164 WP_002262995.1 NC_004350:168768-169214 [Streptococcus mutans UA159]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKADLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK

Download         Length: 447 bp

>AT10164 NC_004350:168768-169214 [Streptococcus mutans UA159]
ATGAAAATGGAAAAGTCAAATAAACAAGTCATTTACGATGAACGTCAGCAGCAAATTCAACTTAAAAGTTATAGTCTTTC
ATTTTGGTTTGTTATGTTTATACTCTATTTTGCAACCTTTGGAAAGGCTGATTTGTTGCTTAATATCGCTTTTTGGGGAG
GACTTGTTCTTAATTTTTGCTACAGTACTCTAAGAGGTGTCGGTCCTTTTGTTGACCCACGTTTTGGAAAAATTGCAAAA
ATCGGTCGTTTGGCCGCTGTTCCTCTTATTTTTTTGGGAATGCTAGTCTTTCTTGTTGCTATCATAATGTCTATTCTAGA
ACATGATAGTTTAAGAGAATCTATCACAAAATGCTCCTACTTAGGCTTATCTGGTTTTTGGCTAATTTGTATGGGAGCAA
GTATCGTCTACCGTCATTATCTTGATAAGAAAGAAGCAGACAAATGA

Regulator


Download         Length: 65 a.a.        Molecular weight: 7105.26 Da        Isoelectric Point: 7.7920

>RE10164 WP_002262994.1 NC_004350:169211-169405 [Streptococcus mutans UA159]
MKNLRLKAARAGKDLSQQALADLVGVSRQTIAAVEKGDYNPTINLCIKICKALDKSLDELFWEE

Download         Length: 195 bp

>RE10164 NC_004350:169211-169405 [Streptococcus mutans UA159]
ATGAAAAATTTACGTTTGAAAGCTGCGCGTGCCGGTAAAGATCTGTCTCAGCAGGCTTTAGCTGATTTAGTTGGGGTATC
TCGTCAAACGATTGCAGCTGTGGAAAAAGGAGATTACAATCCGACAATTAACCTTTGCATCAAGATTTGTAAAGCTTTGG
ACAAGAGTTTAGATGAGCTGTTTTGGGAAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8DWA1

Antitoxin

Source ID Structure
AlphaFold DB Q8DWA0

References

(1) Delphine Dufour et al. (2018) A tripartite toxin-antitoxin module induced by quorum sensing is associated with the persistence phenotype in Streptococcus mutans. Molecular Oral Microbiology 33(6):420-429. [PubMed:30298644] experimental


experimental experimental literature