Detailed information of TA system TA152455

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 1722996..1723567
• Replicon: chromosome
• Accession: NZ_CP050271
• Organism: Streptococcus mutans strain S1

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: Q8DW95
• Locus tag: HB752_RS08455
• Protein ID: WP_002262989.1
• Coordinates: 1722996..1723328 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: HB752_RS08460
• Protein ID: WP_019315031.1
• Coordinates: 1723322..1723567 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB752_RS08430	1718515..1719117	-	603	WP_002271857.1	NAD(P)H-dependent oxidoreductase	-
HB752_RS08435	1719259..1720107	-	849	WP_002265112.1	alpha/beta hydrolase	-
HB752_RS08440	1720085..1721305	-	1221	WP_002267692.1	PTS sugar transporter subunit IIC	-
HB752_RS08445	1721487..1721840	-	354	Protein_1637	transposase family protein	-
HB752_RS08450	1722007..1722798	+	792	WP_025985815.1	DUF4037 domain-containing protein	-
HB752_RS08455	1722996..1723328	-	333	WP_002262989.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HB752_RS08460	1723322..1723567	-	246	WP_019315031.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HB752_RS08465	1724170..1724541	-	372	WP_049473463.1	type II toxin-antitoxin system death-on-curing family toxin	-
HB752_RS08470	1724538..1724795	-	258	WP_049473464.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HB752_RS08475	1724917..1726755	-	1839	Protein_1643	hypothetical protein	-
HB752_RS08480	1727024..1728049	-	1026	WP_080351607.1	winged helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1717845..1754028	36183
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_004350 Streptococcus mutans UA159 IS/Tn TA000663, TA010164 172710..172838 0	flank	IS/Tn	-	-	1721712..1721840	128

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (5-107)

Antitoxin

• Antitoxin PemI-like (1-81)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12640.50 Da
• Isoelectric Point: 6.4634

>T152455 WP_002262989.1 NZ_CP050271:c1723328-1722996 [Streptococcus mutans]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIGIFAPISNTKRDYPFYVSLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Nucleotide

• Length: 333 bp

>T152455 NZ_CP066169:3784541-3784891 [Pseudomonas simiae]
ATGGATGCTCTATTTATCGAACTGCCGGCCTTCGAGCGGCATCGCAAGGACTATCTGAGTGACGAGCTTTTCCACGGTTT
TCAACAGGCGTTGATGAAGAACCCGGAAGCGGGAGACGTGATCGAGGGAACAGGCGGGTTACGCAAGGTTAGCTTTGTCG
ACGAACGACGCAACAAAGGCAAGCGCGGTGGCCTGCGGGTCATTTACTACTGGTGGTCAGACGGCACGCAATTCTGGTTA
TTCACCCTGTACGGCAAACACGAACAGGACGACCTGACGCCTCAGCACAAAAAAGCCCTAAAACACATGCTGGACAGGGA
AATCAAAGCGAGAACACATCATGAAACGTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9241.52 Da
• Isoelectric Point: 4.3021

>AT152455 WP_019315031.1 NZ_CP050271:c1723567-1723322 [Streptococcus mutans]
MQLVINKWGNSSAVRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNVPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W

Nucleotide

• Length: 246 bp

>AT152455 NZ_CP066169:3784881-3785195 [Pseudomonas simiae]
ATGAAACGTGAAATCTTTTCCGAACTGGTCGAAGGCTTCGACGCCCTGGCAAACGAACGCCAAGGCAAAGTCACCCTGCG
GACCCACAAGGTTCATCTCAACAACCTGGAGCCGCTCACCGCAGAGGAAGTGGTCGCCGTGCGTCAACAGCTCAACCTCT
CCCGTGCCGTCTTCGCCATGTACCTGCGCACCAACACGCGTACGCTGGAGAACTGGGAGCAAGGCCGGGCTAAACCAAAT
GCCCAGGCCGCCACCCTGATTCGCCTGGTGGCGCGTTTTCCTGAGACCGTGGCACAACTTGCTGCGTTGGGTTGA

Structures

Toxin

• AlphaFold DB: Q8DW95