Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1722996..1723567 Replicon chromosome
Accession NZ_CP050271
Organism Streptococcus mutans strain S1

Toxin (Protein)


Gene name mazF Uniprot ID Q8DW95
Locus tag HB752_RS08455 Protein ID WP_002262989.1
Coordinates 1722996..1723328 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HB752_RS08460 Protein ID WP_019315031.1
Coordinates 1723322..1723567 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB752_RS08430 1718515..1719117 - 603 WP_002271857.1 NAD(P)H-dependent oxidoreductase -
HB752_RS08435 1719259..1720107 - 849 WP_002265112.1 alpha/beta hydrolase -
HB752_RS08440 1720085..1721305 - 1221 WP_002267692.1 PTS sugar transporter subunit IIC -
HB752_RS08445 1721487..1721840 - 354 Protein_1637 transposase family protein -
HB752_RS08450 1722007..1722798 + 792 WP_025985815.1 DUF4037 domain-containing protein -
HB752_RS08455 1722996..1723328 - 333 WP_002262989.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HB752_RS08460 1723322..1723567 - 246 WP_019315031.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HB752_RS08465 1724170..1724541 - 372 WP_049473463.1 type II toxin-antitoxin system death-on-curing family toxin -
HB752_RS08470 1724538..1724795 - 258 WP_049473464.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HB752_RS08475 1724917..1726755 - 1839 Protein_1643 hypothetical protein -
HB752_RS08480 1727024..1728049 - 1026 WP_080351607.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1717845..1754028 36183
flank IS/Tn - - 1721712..1721840 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

Antitoxin PemI-like

(1-81)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12640.50 Da        Isoelectric Point: 6.4634

>T152455 WP_002262989.1 NZ_CP050271:c1723328-1722996 [Streptococcus mutans]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIGIFAPISNTKRDYPFYVSLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Download         Length: 333 bp

>T152455 NZ_CP066169:3784541-3784891 [Pseudomonas simiae]
ATGGATGCTCTATTTATCGAACTGCCGGCCTTCGAGCGGCATCGCAAGGACTATCTGAGTGACGAGCTTTTCCACGGTTT
TCAACAGGCGTTGATGAAGAACCCGGAAGCGGGAGACGTGATCGAGGGAACAGGCGGGTTACGCAAGGTTAGCTTTGTCG
ACGAACGACGCAACAAAGGCAAGCGCGGTGGCCTGCGGGTCATTTACTACTGGTGGTCAGACGGCACGCAATTCTGGTTA
TTCACCCTGTACGGCAAACACGAACAGGACGACCTGACGCCTCAGCACAAAAAAGCCCTAAAACACATGCTGGACAGGGA
AATCAAAGCGAGAACACATCATGAAACGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9241.52 Da        Isoelectric Point: 4.3021

>AT152455 WP_019315031.1 NZ_CP050271:c1723567-1723322 [Streptococcus mutans]
MQLVINKWGNSSAVRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNVPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W

Download         Length: 246 bp

>AT152455 NZ_CP066169:3784881-3785195 [Pseudomonas simiae]
ATGAAACGTGAAATCTTTTCCGAACTGGTCGAAGGCTTCGACGCCCTGGCAAACGAACGCCAAGGCAAAGTCACCCTGCG
GACCCACAAGGTTCATCTCAACAACCTGGAGCCGCTCACCGCAGAGGAAGTGGTCGCCGTGCGTCAACAGCTCAACCTCT
CCCGTGCCGTCTTCGCCATGTACCTGCGCACCAACACGCGTACGCTGGAGAACTGGGAGCAAGGCCGGGCTAAACCAAAT
GCCCAGGCCGCCACCCTGATTCGCCTGGTGGCGCGTTTTCCTGAGACCGTGGCACAACTTGCTGCGTTGGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8DW95

Antitoxin

Source ID Structure

References