45851

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 170867..171438 Replicon chromosome
Accession NZ_CP007016
Organism Streptococcus mutans UA159-FR

Toxin (Protein)


Gene name mazF Uniprot ID Q8DW95
Locus tag SMUFR_RS00845 Protein ID WP_002262989.1
Coordinates 171106..171438 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q8DW96
Locus tag SMUFR_RS00840 Protein ID WP_002262990.1
Coordinates 170867..171112 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMUFR_RS00805 166375..167121 + 747 WP_002262998.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
SMUFR_RS00810 167145..168005 + 861 WP_002262997.1 DegV family protein -
SMUFR_RS00815 168137..168652 + 516 WP_002262996.1 hypothetical protein -
SMUFR_RS00820 168652..169098 + 447 WP_002262995.1 hypothetical protein -
SMUFR_RS00825 169095..169289 + 195 WP_002262994.1 helix-turn-helix transcriptional regulator -
SMUFR_RS00830 169682..170128 + 447 WP_002262993.1 50S ribosomal protein L13 -
SMUFR_RS00835 170153..170545 + 393 WP_002262992.1 30S ribosomal protein S9 -
SMUFR_RS00840 170867..171112 + 246 WP_002262990.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SMUFR_RS00845 171106..171438 + 333 WP_002262989.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SMUFR_RS00850 171636..172427 - 792 WP_002262988.1 DUF4037 domain-containing protein -
SMUFR_RS10770 172594..172947 + 354 Protein_151 transposase family protein -
SMUFR_RS00855 173129..174349 + 1221 WP_002262024.1 PTS sugar transporter subunit IIC -
SMUFR_RS00860 174327..175175 + 849 WP_002262025.1 alpha/beta hydrolase -
SMUFR_RS00865 175317..175919 + 603 WP_002262026.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 172594..172722 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12640.50 Da        Isoelectric Point: 6.4634

>T45851 WP_002262989.1 NZ_CP007016:171106-171438 [Streptococcus mutans UA159-FR]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIGIFAPISNTKRDYPFYVSLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Download         Length: 333 bp

>T45851 NZ_CP007016:171106-171438 [Streptococcus mutans UA159-FR]
ATGGTAACCATCAAGCAAGGGTCAATTATCAAAATTAACTTGGATCCCAAACAAGGACATGAACAAAAAGGGTATCGTCC
GTACATTTGTCTAAACCATAGTATCGTAACCAAGTATTCTAATATTGGTATTTTTGCGCCAATTAGCAATACCAAGCGTG
ATTATCCTTTTTATGTTTCCCTAGAAGGAACAGAATCCACAGGGAAAGTATTATTAGACCAACTGGTTACAATCGATTTT
AATGCTAGAGATTATCGTTATGTGGAGGATATTCAGGAAGACTTATTAGATGAACTTTTAGCTAGGGTCAAGGTGCTATT
TGAAAAAGGATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9241.52 Da        Isoelectric Point: 4.3021

>AT45851 WP_002262990.1 NZ_CP007016:170867-171112 [Streptococcus mutans UA159-FR]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNIPELTVEDLFKDYQGEPVNVTPALFESVGNEQ
W

Download         Length: 246 bp

>AT45851 NZ_CP007016:170867-171112 [Streptococcus mutans UA159-FR]
ATGCAACTAGTCATCAATAAATGGGGAAATAGCTCCGCTATTCGTTTGCCAAAACAATTGGTACAAGAATTACAATTACA
AACAAATGATGTCTTAGACTATAAGGTATCAGGGAATAAAATTATCCTAGAAAAAGTGAATAATATCCCTGAATTAACTG
TAGAAGATCTGTTTAAAGATTATCAAGGTGAACCTGTCAATGTTACCCCAGCTCTATTTGAAAGTGTGGGAAATGAACAA
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8DW95

Antitoxin

Source ID Structure
AlphaFold DB Q8DW96

References