Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 1727658..1728229 | Replicon | chromosome |
| Accession | NZ_CP050273 | ||
| Organism | Streptococcus mutans strain P1 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | Q8DW95 |
| Locus tag | HB750_RS08465 | Protein ID | WP_002262989.1 |
| Coordinates | 1727658..1727990 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | - |
| Locus tag | HB750_RS08470 | Protein ID | WP_019315031.1 |
| Coordinates | 1727984..1728229 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HB750_RS08440 | 1723177..1723779 | - | 603 | WP_002271857.1 | NAD(P)H-dependent oxidoreductase | - |
| HB750_RS08445 | 1723921..1724769 | - | 849 | WP_002265112.1 | alpha/beta hydrolase | - |
| HB750_RS08450 | 1724747..1725967 | - | 1221 | WP_002267692.1 | PTS sugar transporter subunit IIC | - |
| HB750_RS08455 | 1726149..1726502 | - | 354 | Protein_1639 | transposase family protein | - |
| HB750_RS08460 | 1726669..1727460 | + | 792 | WP_025985815.1 | DUF4037 domain-containing protein | - |
| HB750_RS08465 | 1727658..1727990 | - | 333 | WP_002262989.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| HB750_RS08470 | 1727984..1728229 | - | 246 | WP_019315031.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| HB750_RS08475 | 1728832..1729203 | - | 372 | WP_049473463.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| HB750_RS08480 | 1729200..1729457 | - | 258 | WP_049473464.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HB750_RS08485 | 1729579..1731417 | - | 1839 | Protein_1645 | hypothetical protein | - |
| HB750_RS08490 | 1731686..1732711 | - | 1026 | WP_080351607.1 | winged helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1722507..1758690 | 36183 | |
| flank | IS/Tn | - | - | 1726374..1726502 | 128 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 12640.50 Da Isoelectric Point: 6.4634
>T152463 WP_002262989.1 NZ_CP050273:c1727990-1727658 [Streptococcus mutans]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIGIFAPISNTKRDYPFYVSLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIGIFAPISNTKRDYPFYVSLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG
Download Length: 333 bp
>T152463 NZ_CP066174:51839-52321 [Klebsiella quasipneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCACTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACCTTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCACTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACCTTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9241.52 Da Isoelectric Point: 4.3021
>AT152463 WP_019315031.1 NZ_CP050273:c1728229-1727984 [Streptococcus mutans]
MQLVINKWGNSSAVRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNVPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W
MQLVINKWGNSSAVRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNVPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W
Download Length: 246 bp
>AT152463 NZ_CP066174:51585-51851 [Klebsiella quasipneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGTACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGTACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|