Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | SmuAT/- |
| Location | 168137..169098 | Replicon | chromosome |
| Accession | NZ_CP007016 | ||
| Organism | Streptococcus mutans UA159-FR | ||
Toxin (Protein)
| Gene name | smuT | Uniprot ID | Q8DWA1 |
| Locus tag | SMUFR_RS00815 | Protein ID | WP_002262996.1 |
| Coordinates | 168137..168652 (+) | Length | 172 a.a. |
Antitoxin (Protein)
| Gene name | smuA | Uniprot ID | Q8DWA0 |
| Locus tag | SMUFR_RS00820 | Protein ID | WP_002262995.1 |
| Coordinates | 168652..169098 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SMUFR_RS00790 | 163554..164291 | + | 738 | WP_002263001.1 | MerR family transcriptional regulator | - |
| SMUFR_RS00795 | 164327..165319 | - | 993 | WP_002263000.1 | BtrH N-terminal domain-containing protein | - |
| SMUFR_RS00800 | 165508..166062 | - | 555 | WP_002262999.1 | PadR family transcriptional regulator | - |
| SMUFR_RS00805 | 166375..167121 | + | 747 | WP_002262998.1 | 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB | - |
| SMUFR_RS00810 | 167145..168005 | + | 861 | WP_002262997.1 | DegV family protein | - |
| SMUFR_RS00815 | 168137..168652 | + | 516 | WP_002262996.1 | hypothetical protein | Toxin |
| SMUFR_RS00820 | 168652..169098 | + | 447 | WP_002262995.1 | hypothetical protein | Antitoxin |
| SMUFR_RS00825 | 169095..169289 | + | 195 | WP_002262994.1 | helix-turn-helix transcriptional regulator | - |
| SMUFR_RS00830 | 169682..170128 | + | 447 | WP_002262993.1 | 50S ribosomal protein L13 | - |
| SMUFR_RS00835 | 170153..170545 | + | 393 | WP_002262992.1 | 30S ribosomal protein S9 | - |
| SMUFR_RS00840 | 170867..171112 | + | 246 | WP_002262990.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| SMUFR_RS00845 | 171106..171438 | + | 333 | WP_002262989.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| SMUFR_RS00850 | 171636..172427 | - | 792 | WP_002262988.1 | DUF4037 domain-containing protein | - |
| SMUFR_RS10770 | 172594..172947 | + | 354 | Protein_151 | transposase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| flank | IS/Tn | - | - | 172594..172722 | 128 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 172 a.a. Molecular weight: 19398.99 Da Isoelectric Point: 9.7364
>T45850 WP_002262996.1 NZ_CP007016:168137-168652 [Streptococcus mutans UA159-FR]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTAGKNKKFLYVYAVIIAVQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTAGKNKKFLYVYAVIIAVQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK
Download Length: 516 bp
>T45850 NZ_CP007016:168137-168652 [Streptococcus mutans UA159-FR]
ATGTTTGACCTTGTTGTTAATTTGATTTTATTGGTTATTGTGATAGGTGGATTTGTCTTCTTAAGATTCTATGCGGATAA
GAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGG
GTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTC
TTTCTTATCGTAGGCGTCTTTGTCTGCAGCAGTATCTTAAACGATGCTTATTTCACAGCAGGAAAAAACAAAAAATTCCT
CTATGTGTATGCCGTTATTATTGCTGTTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACG
GACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGCTGTCATTTTTCTAGTAACTGCT
TATAAAACGATTCAGGATAAGAGAGAGGGAAAGTGA
ATGTTTGACCTTGTTGTTAATTTGATTTTATTGGTTATTGTGATAGGTGGATTTGTCTTCTTAAGATTCTATGCGGATAA
GAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGG
GTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTC
TTTCTTATCGTAGGCGTCTTTGTCTGCAGCAGTATCTTAAACGATGCTTATTTCACAGCAGGAAAAAACAAAAAATTCCT
CTATGTGTATGCCGTTATTATTGCTGTTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACG
GACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGCTGTCATTTTTCTAGTAACTGCT
TATAAAACGATTCAGGATAAGAGAGAGGGAAAGTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16968.23 Da Isoelectric Point: 9.5767
>AT45850 WP_002262995.1 NZ_CP007016:168652-169098 [Streptococcus mutans UA159-FR]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKADLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKADLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK
Download Length: 447 bp
>AT45850 NZ_CP007016:168652-169098 [Streptococcus mutans UA159-FR]
ATGAAAATGGAAAAGTCAAATAAACAAGTCATTTACGATGAACGTCAGCAGCAAATTCAACTTAAAAGTTATAGTCTTTC
ATTTTGGTTTGTTATGTTTATACTCTATTTTGCAACCTTTGGAAAGGCTGATTTGTTGCTTAATATCGCTTTTTGGGGAG
GACTTGTTCTTAATTTTTGCTACAGTACTCTAAGAGGTGTCGGTCCTTTTGTTGACCCACGTTTTGGAAAAATTGCAAAA
ATCGGTCGTTTGGCCGCTGTTCCTCTTATTTTTTTGGGAATGCTAGTCTTTCTTGTTGCTATCATAATGTCTATTCTAGA
ACATGATAGTTTAAGAGAATCTATCACAAAATGCTCCTACTTAGGCTTATCTGGTTTTTGGCTAATTTGTATGGGAGCAA
GTATCGTCTACCGTCATTATCTTGATAAGAAAGAAGCAGACAAATGA
ATGAAAATGGAAAAGTCAAATAAACAAGTCATTTACGATGAACGTCAGCAGCAAATTCAACTTAAAAGTTATAGTCTTTC
ATTTTGGTTTGTTATGTTTATACTCTATTTTGCAACCTTTGGAAAGGCTGATTTGTTGCTTAATATCGCTTTTTGGGGAG
GACTTGTTCTTAATTTTTGCTACAGTACTCTAAGAGGTGTCGGTCCTTTTGTTGACCCACGTTTTGGAAAAATTGCAAAA
ATCGGTCGTTTGGCCGCTGTTCCTCTTATTTTTTTGGGAATGCTAGTCTTTCTTGTTGCTATCATAATGTCTATTCTAGA
ACATGATAGTTTAAGAGAATCTATCACAAAATGCTCCTACTTAGGCTTATCTGGTTTTTGGCTAATTTGTATGGGAGCAA
GTATCGTCTACCGTCATTATCTTGATAAGAAAGAAGCAGACAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|