Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 170790..171361 Replicon chromosome
Accession NZ_CP101984
Organism Streptococcus mutans strain UA-159

Toxin (Protein)


Gene name mazF Uniprot ID Q8DW95
Locus tag NPS18_RS00865 Protein ID WP_002262989.1
Coordinates 171029..171361 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q8DW96
Locus tag NPS18_RS00860 Protein ID WP_002262990.1
Coordinates 170790..171035 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPS18_RS00825 (NPS18_00825) 166298..167044 + 747 WP_002262998.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
NPS18_RS00830 (NPS18_00830) 167068..167928 + 861 WP_002262997.1 DegV family protein -
NPS18_RS00835 (NPS18_00835) 168060..168575 + 516 WP_002262996.1 hypothetical protein -
NPS18_RS00840 (NPS18_00840) 168575..169021 + 447 WP_002262995.1 hypothetical protein -
NPS18_RS00845 (NPS18_00845) 169018..169212 + 195 WP_002262994.1 helix-turn-helix transcriptional regulator -
NPS18_RS00850 (NPS18_00850) 169605..170051 + 447 WP_002262993.1 50S ribosomal protein L13 -
NPS18_RS00855 (NPS18_00855) 170076..170468 + 393 WP_002262992.1 30S ribosomal protein S9 -
NPS18_RS00860 (NPS18_00860) 170790..171035 + 246 WP_002262990.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NPS18_RS00865 (NPS18_00865) 171029..171361 + 333 WP_002262989.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NPS18_RS00870 (NPS18_00870) 171559..172350 - 792 WP_002262988.1 nucleotidyltransferase domain-containing protein -
NPS18_RS00875 (NPS18_00875) 172517..172870 + 354 Protein_151 transposase family protein -
NPS18_RS00880 (NPS18_00880) 173052..174272 + 1221 WP_002262024.1 PTS sugar transporter subunit IIC -
NPS18_RS00885 (NPS18_00885) 174250..175098 + 849 WP_002262025.1 alpha/beta hydrolase -
NPS18_RS00890 (NPS18_00890) 175240..175842 + 603 WP_002262026.1 NADPH-dependent FMN reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 172517..172645 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12640.50 Da        Isoelectric Point: 6.4634

>T253059 WP_002262989.1 NZ_CP101984:171029-171361 [Streptococcus mutans]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIGIFAPISNTKRDYPFYVSLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9241.52 Da        Isoelectric Point: 4.3021

>AT253059 WP_002262990.1 NZ_CP101984:170790-171035 [Streptococcus mutans]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNIPELTVEDLFKDYQGEPVNVTPALFESVGNEQ
W

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8DW95

Antitoxin

Source ID Structure
AlphaFold DB Q8DW96

References