Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1453566..1454137 Replicon chromosome
Accession NZ_CP050272
Organism Streptococcus mutans strain P6

Toxin (Protein)


Gene name mazF Uniprot ID Q8DW95
Locus tag HB751_RS07090 Protein ID WP_002262989.1
Coordinates 1453566..1453898 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HB751_RS07095 Protein ID WP_019315031.1
Coordinates 1453892..1454137 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB751_RS07065 1449085..1449687 - 603 WP_002271857.1 NAD(P)H-dependent oxidoreductase -
HB751_RS07070 1449829..1450677 - 849 WP_002265112.1 alpha/beta hydrolase -
HB751_RS07075 1450655..1451875 - 1221 WP_002267692.1 PTS sugar transporter subunit IIC -
HB751_RS07080 1452057..1452410 - 354 Protein_1379 transposase family protein -
HB751_RS07085 1452577..1453368 + 792 WP_025985815.1 DUF4037 domain-containing protein -
HB751_RS07090 1453566..1453898 - 333 WP_002262989.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HB751_RS07095 1453892..1454137 - 246 WP_019315031.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HB751_RS07100 1454740..1455111 - 372 WP_049473463.1 type II toxin-antitoxin system death-on-curing family toxin -
HB751_RS07105 1455108..1455365 - 258 WP_049473464.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HB751_RS07110 1455487..1457325 - 1839 Protein_1385 hypothetical protein -
HB751_RS07115 1457594..1458619 - 1026 WP_080351607.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1448415..1484598 36183
flank IS/Tn - - 1452282..1452410 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

Antitoxin PemI-like

(1-81)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12640.50 Da        Isoelectric Point: 6.4634

>T152459 WP_002262989.1 NZ_CP050272:c1453898-1453566 [Streptococcus mutans]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIGIFAPISNTKRDYPFYVSLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Download         Length: 333 bp

>T152459 NZ_CP066173:1825558-1825660 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9241.52 Da        Isoelectric Point: 4.3021

>AT152459 WP_019315031.1 NZ_CP050272:c1454137-1453892 [Streptococcus mutans]
MQLVINKWGNSSAVRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNVPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W

Download         Length: 246 bp

>AT152459 NZ_CP066173:c1825664-1825517 [Klebsiella quasipneumoniae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8DW95

Antitoxin

Source ID Structure

References