Detailed information of TA system TA023993

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Xre-MNT/HTH_26(antitoxin)
• Location: 926329..927437
• Replicon: chromosome
• Accession: NC_012924
• Organism: Streptococcus suis SC84

Toxin (Protein)

• Gene name: MNTss
• Uniprot ID: R3JIN1
• Locus tag: SSUSC84_RS04580
• Protein ID: WP_000233000.1
• Coordinates: 926568..927437 (+)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: Xress
• Uniprot ID: -
• Locus tag: SSUSC84_RS04575
• Protein ID: WP_000205227.1
• Coordinates: 926329..926553 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSUSC84_RS04555	922269..923381	-	1113	WP_011922450.1	lantibiotic-modifying protein	-
SSUSC84_RS10895	923708..923872	+	165	Protein_848	DNA recombinase	-
SSUSC84_RS04560 (SSUSC84_0857)	923909..924205	+	297	WP_002360685.1	hypothetical protein	-
SSUSC84_RS04565 (SSUSC84_0858)	924206..924622	+	417	WP_000323438.1	recombinase	-
SSUSC84_RS04570 (SSUSC84_0859)	924642..926186	+	1545	WP_002390960.1	recombinase family protein	-
SSUSC84_RS04575 (SSUSC84_0860)	926329..926553	+	225	WP_000205227.1	helix-turn-helix transcriptional regulator	Antitoxin
SSUSC84_RS04580 (SSUSC84_0861)	926568..927437	+	870	WP_000233000.1	nucleotidyltransferase domain-containing protein	Toxin
SSUSC84_RS04585 (SSUSC84_0862)	927418..928152	+	735	WP_000662263.1	class I SAM-dependent methyltransferase	-
SSUSC84_RS04590 (SSUSC84_0863)	928185..929048	+	864	WP_002294505.1	aminoglycoside nucleotidyltransferase ANT(6)-Ia	-
SSUSC84_RS04595 (SSUSC84_0864)	929092..929619	+	528	WP_002294507.1	adenine phosphoribosyltransferase	-
SSUSC84_RS04600 (SSUSC84_0865)	929847..931166	+	1320	WP_002338419.1	IS1380-like element ISSsu5 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NZ_CP007497 Streptococcus suis strain ZY05719 isolate diseased pig Integrative and Conjugative Element TA010053, TA046533, TA046534, TA046536 808718..964358 0 View NZ_CP018908 Streptococcus suis strain SS2-1 Integrative and Conjugative Element TA070792, TA070793, TA070794, TA070795 785098..940739 0 View NZ_CP020863 Streptococcus suis strain SC19 Integrative and Conjugative Element TA075581, TA075582, TA075583, TA075584 808893..964533 0 View NZ_CP007497 Streptococcus suis strain ZY05719 isolate diseased pig Integrative and Conjugative Element TA010053, TA046533, TA046534, TA046536 808718..964358 0	inside	Integrative and Conjugative Element	tet(M) / ant(6)-Ia	-	808819..964460	155641
	-	flank	IS/Tn	ant(6)-Ia	-	928185..931166	2981

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polymerase, nucleotidyl transferase domain (12-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-57)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 32926.57 Da
• Isoelectric Point: 4.8781

>T23993 WP_000233000.1 NC_012924:926568-927437 [Streptococcus suis SC84]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Nucleotide

• Length: 870 bp

>T23993 NC_012924:926568-927437 [Streptococcus suis SC84]
ATGGTAGGTAATGTTATTCAAATAGTAACAGAGAAATTATCATCTTTGCCTTTTATAGAAGGCATCGTATTAGGGGGCTC
ACGTGCAAGAGGCACCCATACAGAAAATTCTGATATAGATATCGGAATCTATTACAATTCAGACTCATTTGACCTGACAG
CGATTAATCAAATTGCTACAGAATTGGATGATAAAAATAGAAACAACCTTGTTGTGCCTCCCGGAGCGTGGGGTGATTGG
ATTAATGGCGGCGGATGGTTATTTATAAATGGGTATCATGTTGACTTGATTTTACGTGATATAAAACGGGTAGAACAAAT
AATCAAAGATACGGAGCAAGGAATTGTTACTGCCAATTATCAGACCGGGCATCCCCATGGTTATATAAGTGCAATGTATC
GTGGAGAATTAGCGATTAGTAAAATACTATATGCTAAGAACGAAAGCTTATGCGAATTAAAAAAGCAGGCAGAAATTTAC
CCTACTGCTCTAAAGAAAAGCTTGATGAACTTTTTTATATTTGAAGCTGAATTCTCTTTAATGTTTGTAAAAGCAAATGC
GGGGGTAGAGGATAAATATTATATTGCAGGCCATGTTTTTCGTATTATTTCATGCTTAAATCAAGTACTATTTGCATGTA
ATAATGCTTATTGCATTAACGAAAAGAAAGCTATAAAACTGCTTGAAACTTTTGAATATAAACCTGAAAAATATGCCGAA
AGAGTTAATCATATTTTTGAAGTACTCGGTCTTTCTCTTTTTGAATGCTACGATATGACCGAGAAACTTTATAAAGAAGT
GAATGAAATTGTATCGGAGATAAATAACTTTTTAAACGAGGAGAGTTCAGATGAAAGAAAACAAATATGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8365.68 Da
• Isoelectric Point: 4.5510

>AT23993 WP_000205227.1 NC_012924:926329-926553 [Streptococcus suis SC84]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Nucleotide

• Length: 225 bp

>AT23993 NC_012924:926329-926553 [Streptococcus suis SC84]
ATGACTACGGCAGAAATGATTAAAGAACTGTGTGAGCAAATGAATATAAGTGTTTCCGAACTTGCTAGACGTATTGGCCA
GACTCCACAGAATTTCAATAAAAAATTACAACGAGAAACAGTAACCTTGGATGAGTTGAAGGCCATTGCTGATGTGCTAG
GTGTCAAGTTTGTGCAGGCATTTATTTTACCAGATGGAGAAGAAATAAAAATATCTAACGAATAA

Structures

Toxin

• AlphaFold DB: R3JIN1