Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 926329..927437 Replicon chromosome
Accession NC_012924
Organism Streptococcus suis SC84

Toxin (Protein)


Gene name MNTss Uniprot ID R3JIN1
Locus tag SSUSC84_RS04580 Protein ID WP_000233000.1
Coordinates 926568..927437 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag SSUSC84_RS04575 Protein ID WP_000205227.1
Coordinates 926329..926553 (+) Length 75 a.a.

Genomic Context

SSUSC84_RS10895SSUSC84_RS04560SSUSC84_RS04565SSUSC84_RS04570SSUSC84_RS04575SSUSC84_RS04580SSUSC84_RS04585SSUSC84_RS04590SSUSC84_RS04595SSUSC84_RS04600SSUSC84_RS04555
Location: 923708..923872 (165 bp)
Type: Others
Protein ID: Protein_848
Location: 923909..924205 (297 bp)
Type: Others
Protein ID: WP_002360685.1
Location: 924206..924622 (417 bp)
Type: Others
Protein ID: WP_000323438.1
Location: 924642..926186 (1545 bp)
Type: Others
Protein ID: WP_002390960.1
Location: 926329..926553 (225 bp)
Type: Antitoxin
Protein ID: WP_000205227.1
Location: 926568..927437 (870 bp)
Type: Toxin
Protein ID: WP_000233000.1
Location: 927418..928152 (735 bp)
Type: Others
Protein ID: WP_000662263.1
Location: 928185..929048 (864 bp)
Type: Others
Protein ID: WP_002294505.1
Location: 929092..929619 (528 bp)
Type: Others
Protein ID: WP_002294507.1
Location: 929847..931166 (1320 bp)
Type: Others
Protein ID: WP_002338419.1
Location: 922269..923381 (1113 bp)
Type: Others
Protein ID: WP_011922450.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SSUSC84_RS04555922269..923381-1113WP_011922450.1lantibiotic-modifying protein-
SSUSC84_RS10895923708..923872+165Protein_848DNA recombinase-
SSUSC84_RS04560 (SSUSC84_0857)923909..924205+297WP_002360685.1hypothetical protein-
SSUSC84_RS04565 (SSUSC84_0858)924206..924622+417WP_000323438.1recombinase-
SSUSC84_RS04570 (SSUSC84_0859)924642..926186+1545WP_002390960.1recombinase family protein-
SSUSC84_RS04575 (SSUSC84_0860)926329..926553+225WP_000205227.1helix-turn-helix transcriptional regulatorAntitoxin
SSUSC84_RS04580 (SSUSC84_0861)926568..927437+870WP_000233000.1nucleotidyltransferase domain-containing proteinToxin
SSUSC84_RS04585 (SSUSC84_0862)927418..928152+735WP_000662263.1class I SAM-dependent methyltransferase-
SSUSC84_RS04590 (SSUSC84_0863)928185..929048+864WP_002294505.1aminoglycoside nucleotidyltransferase ANT(6)-Ia-
SSUSC84_RS04595 (SSUSC84_0864)929092..929619+528WP_002294507.1adenine phosphoribosyltransferase-
SSUSC84_RS04600 (SSUSC84_0865)929847..931166+1320WP_002338419.1IS1380-like element ISSsu5 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegrative and Conjugative Elementtet(M) / ant(6)-Ia-808819..964460155641
-flankIS/Tnant(6)-Ia-928185..9311662981


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32926.57 Da        Isoelectric Point: 4.8781

>T23993 WP_000233000.1 NC_012924:926568-927437 [Streptococcus suis SC84]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

>T23993 NC_012924:926568-927437 [Streptococcus suis SC84]
ATGGTAGGTAATGTTATTCAAATAGTAACAGAGAAATTATCATCTTTGCCTTTTATAGAAGGCATCGTATTAGGGGGCTC
ACGTGCAAGAGGCACCCATACAGAAAATTCTGATATAGATATCGGAATCTATTACAATTCAGACTCATTTGACCTGACAG
CGATTAATCAAATTGCTACAGAATTGGATGATAAAAATAGAAACAACCTTGTTGTGCCTCCCGGAGCGTGGGGTGATTGG
ATTAATGGCGGCGGATGGTTATTTATAAATGGGTATCATGTTGACTTGATTTTACGTGATATAAAACGGGTAGAACAAAT
AATCAAAGATACGGAGCAAGGAATTGTTACTGCCAATTATCAGACCGGGCATCCCCATGGTTATATAAGTGCAATGTATC
GTGGAGAATTAGCGATTAGTAAAATACTATATGCTAAGAACGAAAGCTTATGCGAATTAAAAAAGCAGGCAGAAATTTAC
CCTACTGCTCTAAAGAAAAGCTTGATGAACTTTTTTATATTTGAAGCTGAATTCTCTTTAATGTTTGTAAAAGCAAATGC
GGGGGTAGAGGATAAATATTATATTGCAGGCCATGTTTTTCGTATTATTTCATGCTTAAATCAAGTACTATTTGCATGTA
ATAATGCTTATTGCATTAACGAAAAGAAAGCTATAAAACTGCTTGAAACTTTTGAATATAAACCTGAAAAATATGCCGAA
AGAGTTAATCATATTTTTGAAGTACTCGGTCTTTCTCTTTTTGAATGCTACGATATGACCGAGAAACTTTATAAAGAAGT
GAATGAAATTGTATCGGAGATAAATAACTTTTTAAACGAGGAGAGTTCAGATGAAAGAAAACAAATATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT23993 WP_000205227.1 NC_012924:926329-926553 [Streptococcus suis SC84]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp

>AT23993 NC_012924:926329-926553 [Streptococcus suis SC84]
ATGACTACGGCAGAAATGATTAAAGAACTGTGTGAGCAAATGAATATAAGTGTTTCCGAACTTGCTAGACGTATTGGCCA
GACTCCACAGAATTTCAATAAAAAATTACAACGAGAAACAGTAACCTTGGATGAGTTGAAGGCCATTGCTGATGTGCTAG
GTGTCAAGTTTGTGCAGGCATTTATTTTACCAGATGGAGAAGAAATAAAAATATCTAACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBR3JIN1

Antitoxin

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Source
ID
Structure
No matching records found

References