Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 946596..948028 Replicon chromosome
Accession NZ_CP007497
Organism Streptococcus suis strain ZY05719 isolate diseased pig

Toxin (Protein)


Gene name abiEi Uniprot ID A0A0Z8VZ26
Locus tag ZY05719_RS04670 Protein ID WP_011922458.1
Coordinates 947183..948028 (+) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID A0A0Z8YIZ2
Locus tag ZY05719_RS04665 Protein ID WP_011922457.1
Coordinates 946596..947186 (+) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ZY05719_RS04665 (ZY05719_04690) 946596..947186 + 591 WP_011922457.1 transcriptional regulator Antitoxin
ZY05719_RS04670 (ZY05719_04695) 947183..948028 + 846 WP_011922458.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
ZY05719_RS04675 (ZY05719_04700) 948091..950892 - 2802 WP_011922459.1 CHAP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element tet(M) / ant(6)-Ia - 808718..964358 155640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-259)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32518.29 Da        Isoelectric Point: 5.2158

>T46536 WP_011922458.1 NZ_CP007497:947183-948028 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEENFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETVLDFEKIIELLERFKSDP
IQNQQWQNYSKKYSYTKGISLADVLEEMIRLIAVLISINFD

Download         Length: 846 bp

>T46536 NZ_CP007497:947183-948028 [Streptococcus suis]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCTAAGAATACTGGATTAACCTTTAATTCCGTGATGACCTA
TTACTTTCTAGAAGTGATTTTGAAAAAATTAAGTCAGAGTACCTACTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TGTCAAATGTTATTGGAGTTGAATCTCGTAGCACGGTTGATATTGATTTTTTGTTCCATCAAATAACACTCTCAGAAGAT
ACTGTGAAGCAGCAACTCAAAGAAATTTTAGCAGATTCAGAAGAAGGTATATCTTTTGTGATTCAATCCATCACAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTTGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGCGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGAAAATTTTCCA
ATCATTGCTTATACAATTGAAACAATCCTAGCTGAGAAACTTCAAACCATCTATTCACGTAACTTCTTGAACAGCAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAGAAAGAAGACATTGACTTCATTCAATTGAAAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGTGCTCGATTTTGAAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATCAACAATGGCAAAATTATTCGAAAAAATATAGCTATACAAAGGGAATTTCCCTTGCAGATGTTCTTGAGGA
GATGATTCGTCTCATAGCAGTTCTCATTTCTATAAATTTTGATTAA

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23151.74 Da        Isoelectric Point: 7.8272

>AT46536 WP_011922457.1 NZ_CP007497:946596-947186 [Streptococcus suis]
MSKKEILLEFIENHNGIITYKDCKALNIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKENSELGITLVKTPMGNEVRVYDFERIICDFVIHREKIDTELFVKT
LQLYGNYPKKNLTKLYEYATKMSTLAKVKQTLEVLV

Download         Length: 591 bp

>AT46536 NZ_CP007497:946596-947186 [Streptococcus suis]
ATGTCAAAAAAAGAGATTCTACTTGAATTTATAGAAAACCACAATGGCATTATCACCTATAAAGATTGTAAAGCTCTAAA
TATTCCAACAATATATTTGACAAGACTAGAAAAAGAAGGAATTCTATACCGCGTCGAAAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGACGAATACTACTTCTTTCAGTACCGATATCCGAAAGCTGTTTTCTCATATATCTCAGCGCTTTATCTG
CAACAATTTACAGATGAAATTCCTCAATATTTTGACGTAACCATTCCTAGAGGTTACCGTTTTAATACTCCTCCAGCTAA
TCTGAACATTCATTCCGTTTCTAAGGAAAATAGCGAACTAGGAATTACTCTTGTAAAAACCCCTATGGGAAACGAGGTAA
GAGTGTATGATTTCGAACGTATTATCTGTGATTTTGTGATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACTTTACGGAAACTATCCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAGCACCTTGGCCAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8VZ26

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8YIZ2

References