Detailed information of TA system TA075582

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-couple_hipB
• Location: 910407..911659
• Replicon: chromosome
• Accession: NZ_CP020863
• Organism: Streptococcus suis strain SC19

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A0Z9JWN4
• Locus tag: B9H01_RS04615
• Protein ID: WP_011922437.1
• Coordinates: 910407..911183 (-)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: sezA
• Uniprot ID: -
• Locus tag: B9H01_RS04620
• Protein ID: WP_012775115.1
• Coordinates: 911183..911659 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9H01_RS04600	905449..905763	-	315	WP_000420682.1	YdcP family protein	-
B9H01_RS10595	906107..906424	+	318	Protein_832	ATP-binding protein	-
B9H01_RS04605	906519..908336	-	1818	WP_012775114.1	ATP-dependent helicase	-
B9H01_RS04610	908323..910410	-	2088	WP_011922436.1	AAA family ATPase	-
B9H01_RS04615	910407..911183	-	777	WP_011922437.1	zeta toxin family protein	Toxin
B9H01_RS04620	911183..911659	-	477	WP_012775115.1	helix-turn-helix domain-containing protein	Antitoxin
B9H01_RS04625	911729..912019	-	291	WP_024379089.1	hypothetical protein	-
B9H01_RS04630	912069..912458	-	390	WP_011922440.1	methyl-accepting chemotaxis protein	-
B9H01_RS04635	912455..912682	-	228	WP_011922441.1	hypothetical protein	-
B9H01_RS04640	912736..913812	-	1077	WP_011922442.1	toprim domain-containing protein	-
B9H01_RS04645	913851..914489	-	639	WP_011922443.1	hypothetical protein	-
B9H01_RS04650	915890..916489	-	600	WP_011922444.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_012924 Streptococcus suis SC84 Integrative and Conjugative Element TA023991, TA023992, TA023993, TA023994 808819..964460 0 View NZ_CP007497 Streptococcus suis strain ZY05719 isolate diseased pig Integrative and Conjugative Element TA010053, TA046533, TA046534, TA046536 808718..964358 0	inside	Integrative and Conjugative Element	tet(M) / ant(6)-Ia	-	808893..964533	155640

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29171.98 Da
• Isoelectric Point: 5.2489

>T75582 WP_011922437.1 NZ_CP020863:c911183-910407 [Streptococcus suis]
MRLEEFSEAAFQKALQRTIRALIRGKTIPEQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLSELEREQLFDQIQIYQRDRTCIYDSEIDEGSAVEVLQECLFGQWSKVEEEML
KAGQERLGELVSANGEKK

Nucleotide

• Length: 777 bp

>T75582 NZ_CP020863:c911183-910407 [Streptococcus suis]
ATGAGGTTGGAAGAATTTAGTGAGGCTGCATTTCAGAAGGCCTTACAGCGAACCATTCGGGCTTTAATCCGAGGCAAAAC
AATTCCAGAACAACCGAAAGCTATCTTACTTGGAGGACAAAGCGGAGCCGGTAAGACAACGATTCATCGGATTAAGCAAA
AGGAATTTCAAGGCAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAACATCCCAATTACTTAGCACTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACATCTGGTTGATGAACTTAGTAC
ACAAGGTTATCATTTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCGA
AAGGATACCAAGTTTCCTTAGCTGTGATTGGTACCAAACCAGAATTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCTATCGATCCTAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGATAA
CCTAAGCGAGTTAGAAAGAGAGCAACTCTTTGACCAAATTCAAATTTATCAAAGAGATAGAACTTGTATCTATGATTCTG
AAATTGATGAGGGATCCGCGGTAGAAGTGCTACAAGAATGCCTCTTTGGGCAATGGAGTAAAGTCGAGGAAGAGATGTTG
AAGGCCGGACAGGAACGGTTGGGGGAATTAGTCTCAGCTAATGGAGAGAAGAAATGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18282.69 Da
• Isoelectric Point: 4.4750

>AT75582 WP_012775115.1 NZ_CP020863:c911659-911183 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT75582 NZ_CP020863:c911659-911183 [Streptococcus suis]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTCGGGATTTC
ACGCAATAGTCTGAGTCGCTACGAAAATGGAACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACTCCTGTCGAAGATTACCATCTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATCGATATCAAGATAGTCAGGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCAATACGAAAATTTACCTTGTCGATACTTTCGATG
AAATTGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTGGACATGGTGCATCATCGGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Z9JWN4