Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 858894..859386 Replicon chromosome
Accession NC_012924
Organism Streptococcus suis SC84

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag SSUSC84_RS04235 Protein ID WP_011922404.1
Coordinates 858894..859151 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag SSUSC84_RS04240 Protein ID WP_012775104.1
Coordinates 859135..859386 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUSC84_RS04215 (SSUSC84_0787) 854528..855598 + 1071 WP_012775101.1 tyrosine recombinase XerS -
SSUSC84_RS04220 (SSUSC84_0788) 855668..857176 - 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
SSUSC84_RS04225 (SSUSC84_0789) 857252..858193 - 942 WP_012775102.1 sensor histidine kinase -
SSUSC84_RS04230 (SSUSC84_0790) 858190..858855 - 666 WP_012775103.1 response regulator transcription factor -
SSUSC84_RS04235 (SSUSC84_0791) 858894..859151 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUSC84_RS04240 (SSUSC84_0792) 859135..859386 - 252 WP_012775104.1 hypothetical protein Antitoxin
SSUSC84_RS04245 (SSUSC84_0793) 859478..861448 - 1971 WP_012775105.1 FtsX-like permease family protein -
SSUSC84_RS04250 (SSUSC84_0794) 861449..862201 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
SSUSC84_RS04255 (SSUSC84_0795) 862337..863071 - 735 WP_011922410.1 ABC transporter permease -
SSUSC84_RS04260 (SSUSC84_0796) 863073..863819 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element tet(M) / ant(6)-Ia - 808819..964460 155641


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T23991 WP_011922404.1 NC_012924:c859151-858894 [Streptococcus suis SC84]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T23991 NC_012924:c859151-858894 [Streptococcus suis SC84]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT23991 WP_012775104.1 NC_012924:c859386-859135 [Streptococcus suis SC84]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT23991 NC_012924:c859386-859135 [Streptococcus suis SC84]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References