Detailed information of TA system TA023991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 858894..859386
• Replicon: chromosome
• Accession: NC_012924
• Organism: Streptococcus suis SC84

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D5AHJ6
• Locus tag: SSUSC84_RS04235
• Protein ID: WP_011922404.1
• Coordinates: 858894..859151 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D5AHJ7
• Locus tag: SSUSC84_RS04240
• Protein ID: WP_012775104.1
• Coordinates: 859135..859386 (-)
• Length: 84 a.a.

Genomic Context

Location: 854528..855598 (1071 bp)
Type: Others
Protein ID: WP_012775101.1

Location: 855668..857176 (1509 bp)
Type: Others
Protein ID: WP_011922400.1

Location: 857252..858193 (942 bp)
Type: Others
Protein ID: WP_012775102.1

Location: 858190..858855 (666 bp)
Type: Others
Protein ID: WP_012775103.1

Location: 858894..859151 (258 bp)
Type: Toxin
Protein ID: WP_011922404.1

Location: 859135..859386 (252 bp)
Type: Antitoxin
Protein ID: WP_012775104.1

Location: 859478..861448 (1971 bp)
Type: Others
Protein ID: WP_012775105.1

Location: 861449..862201 (753 bp)
Type: Others
Protein ID: WP_011922409.1

Location: 862337..863071 (735 bp)
Type: Others
Protein ID: WP_011922410.1

Location: 863073..863819 (747 bp)
Type: Others
Protein ID: WP_011922411.1

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSUSC84_RS04215 (SSUSC84_0787)	854528..855598	+	1071	WP_012775101.1	tyrosine recombinase XerS	-
SSUSC84_RS04220 (SSUSC84_0788)	855668..857176	-	1509	WP_011922400.1	phosphomannomutase/phosphoglucomutase	-
SSUSC84_RS04225 (SSUSC84_0789)	857252..858193	-	942	WP_012775102.1	sensor histidine kinase	-
SSUSC84_RS04230 (SSUSC84_0790)	858190..858855	-	666	WP_012775103.1	response regulator transcription factor	-
SSUSC84_RS04235 (SSUSC84_0791)	858894..859151	-	258	WP_011922404.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SSUSC84_RS04240 (SSUSC84_0792)	859135..859386	-	252	WP_012775104.1	hypothetical protein	Antitoxin
SSUSC84_RS04245 (SSUSC84_0793)	859478..861448	-	1971	WP_012775105.1	FtsX-like permease family protein	-
SSUSC84_RS04250 (SSUSC84_0794)	861449..862201	-	753	WP_011922409.1	ABC transporter ATP-binding protein	-
SSUSC84_RS04255 (SSUSC84_0795)	862337..863071	-	735	WP_011922410.1	ABC transporter permease	-
SSUSC84_RS04260 (SSUSC84_0796)	863073..863819	-	747	WP_011922411.1	ABC transporter permease	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NZ_CP007497 Streptococcus suis strain ZY05719 isolate diseased pig Integrative and Conjugative Element TA010053, TA046533, TA046534, TA046536 808718..964358 0 View NZ_CP018908 Streptococcus suis strain SS2-1 Integrative and Conjugative Element TA070792, TA070793, TA070794, TA070795 785098..940739 0 View NZ_CP020863 Streptococcus suis strain SC19 Integrative and Conjugative Element TA075581, TA075582, TA075583, TA075584 808893..964533 0 View NZ_CP007497 Streptococcus suis strain ZY05719 isolate diseased pig Integrative and Conjugative Element TA010053, TA046533, TA046534, TA046536 808718..964358 0	inside	Integrative and Conjugative Element	tet(M) / ant(6)-Ia	-	808819..964460	155641

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (10-75)

Antitoxin

• Protein of unknown function DUF6290 (1-75)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9981.62 Da
• Isoelectric Point: 10.8924

>T23991 WP_011922404.1 NC_012924:c859151-858894 [Streptococcus suis SC84]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Nucleotide

• Length: 258 bp

>T23991 NC_012924:c859151-858894 [Streptococcus suis SC84]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9325.59 Da
• Isoelectric Point: 3.7666

>AT23991 WP_012775104.1 NC_012924:c859386-859135 [Streptococcus suis SC84]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Nucleotide

• Length: 252 bp

>AT23991 NC_012924:c859386-859135 [Streptococcus suis SC84]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Structures

Toxin

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• AlphaFold DB: A0A0Z8U747

Antitoxin

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• AlphaFold DB: A0A0Z9GU89