Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 835173..835665 | Replicon | chromosome |
Accession | NZ_CP018908 | ||
Organism | Streptococcus suis strain SS2-1 |
Toxin (Protein)
Gene name | relE | Uniprot ID | D5AHJ6 |
Locus tag | BVD85_RS04170 | Protein ID | WP_011922404.1 |
Coordinates | 835173..835430 (-) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | D5AHJ7 |
Locus tag | BVD85_RS04175 | Protein ID | WP_012775104.1 |
Coordinates | 835414..835665 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BVD85_RS04150 | 830807..831877 | + | 1071 | WP_012775101.1 | tyrosine recombinase XerS | - |
BVD85_RS04155 | 831947..833455 | - | 1509 | WP_011922400.1 | phosphomannomutase/phosphoglucomutase | - |
BVD85_RS04160 | 833531..834472 | - | 942 | WP_012775102.1 | sensor histidine kinase | - |
BVD85_RS04165 | 834469..835134 | - | 666 | WP_012775103.1 | response regulator transcription factor | - |
BVD85_RS04170 | 835173..835430 | - | 258 | WP_011922404.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
BVD85_RS04175 | 835414..835665 | - | 252 | WP_012775104.1 | hypothetical protein | Antitoxin |
BVD85_RS04180 | 835757..837727 | - | 1971 | WP_012775105.1 | FtsX-like permease family protein | - |
BVD85_RS04185 | 837728..838480 | - | 753 | WP_011922409.1 | ABC transporter ATP-binding protein | - |
BVD85_RS04190 | 838616..839350 | - | 735 | WP_011922410.1 | ABC transporter permease | - |
BVD85_RS04195 | 839352..840098 | - | 747 | WP_011922411.1 | ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Integrative and Conjugative Element | tet(M) / ant(6)-Ia | - | 785098..940739 | 155641 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9981.62 Da Isoelectric Point: 10.8924
>T70792 WP_011922404.1 NZ_CP018908:c835430-835173 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI
Download Length: 258 bp
>T70792 NZ_CP018908:c835430-835173 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9325.59 Da Isoelectric Point: 3.7666
>AT70792 WP_012775104.1 NZ_CP018908:c835665-835414 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL
Download Length: 252 bp
>AT70792 NZ_CP018908:c835665-835414 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Z8U747 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Z9GU89 |