46533

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 858792..859284 Replicon chromosome
Accession NZ_CP007497
Organism Streptococcus suis strain ZY05719 isolate diseased pig

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag ZY05719_RS04255 Protein ID WP_011922404.1
Coordinates 858792..859049 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag ZY05719_RS04260 Protein ID WP_012775104.1
Coordinates 859033..859284 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ZY05719_RS04235 (ZY05719_04245) 854426..855496 + 1071 WP_012775101.1 tyrosine recombinase XerS -
ZY05719_RS04240 (ZY05719_04250) 855566..857074 - 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
ZY05719_RS04245 (ZY05719_04255) 857150..858091 - 942 WP_012775102.1 sensor histidine kinase -
ZY05719_RS04250 (ZY05719_04260) 858088..858753 - 666 WP_012775103.1 response regulator transcription factor -
ZY05719_RS04255 (ZY05719_04265) 858792..859049 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ZY05719_RS04260 (ZY05719_04270) 859033..859284 - 252 WP_012775104.1 hypothetical protein Antitoxin
ZY05719_RS04265 (ZY05719_04275) 859376..861346 - 1971 WP_012775105.1 FtsX-like permease family protein -
ZY05719_RS04270 (ZY05719_04280) 861347..862099 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
ZY05719_RS04275 (ZY05719_04285) 862235..862969 - 735 WP_011922410.1 ABC transporter permease -
ZY05719_RS04280 (ZY05719_04290) 862971..863717 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element tet(M) / ant(6)-Ia - 808718..964358 155640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T46533 WP_011922404.1 NZ_CP007497:c859049-858792 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T46533 NZ_CP007497:c859049-858792 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT46533 WP_012775104.1 NZ_CP007497:c859284-859033 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT46533 NZ_CP007497:c859284-859033 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References