Detailed information of TA system TA070794

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Xre-MNT/HTH_26(antitoxin)
• Location: 902608..903716
• Replicon: chromosome
• Accession: NZ_CP018908
• Organism: Streptococcus suis strain SS2-1

Toxin (Protein)

• Gene name: MNTss
• Uniprot ID: R3JIN1
• Locus tag: BVD85_RS04535
• Protein ID: WP_000233000.1
• Coordinates: 902847..903716 (+)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: Xress
• Uniprot ID: -
• Locus tag: BVD85_RS04530
• Protein ID: WP_000205227.1
• Coordinates: 902608..902832 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVD85_RS04510	898548..899660	-	1113	WP_011922450.1	lantibiotic-modifying protein	-
BVD85_RS10730	899987..900151	+	165	Protein_833	DNA recombinase	-
BVD85_RS04515	900188..900484	+	297	WP_002360685.1	hypothetical protein	-
BVD85_RS04520	900485..900901	+	417	WP_000323438.1	recombinase	-
BVD85_RS04525	900921..902465	+	1545	WP_002390960.1	recombinase family protein	-
BVD85_RS04530	902608..902832	+	225	WP_000205227.1	helix-turn-helix transcriptional regulator	Antitoxin
BVD85_RS04535	902847..903716	+	870	WP_000233000.1	nucleotidyltransferase domain-containing protein	Toxin
BVD85_RS04540	903697..904431	+	735	WP_000662263.1	class I SAM-dependent methyltransferase	-
BVD85_RS04545	904464..905327	+	864	WP_002294505.1	aminoglycoside nucleotidyltransferase ANT(6)-Ia	-
BVD85_RS04550	905371..905898	+	528	WP_002294507.1	adenine phosphoribosyltransferase	-
BVD85_RS04555	906126..907445	+	1320	WP_002338419.1	IS1380-like element ISSsu5 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_012924 Streptococcus suis SC84 Integrative and Conjugative Element TA023991, TA023992, TA023993, TA023994 808819..964460 0 View NZ_CP007497 Streptococcus suis strain ZY05719 isolate diseased pig Integrative and Conjugative Element TA010053, TA046533, TA046534, TA046536 808718..964358 0	inside	Integrative and Conjugative Element	tet(M) / ant(6)-Ia	-	785098..940739	155641
	-	flank	IS/Tn	ant(6)-Ia	-	904464..907445	2981

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polymerase, nucleotidyl transferase domain (12-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-57)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 32926.57 Da
• Isoelectric Point: 4.8781

>T70794 WP_000233000.1 NZ_CP018908:902847-903716 [Streptococcus suis]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Nucleotide

• Length: 870 bp

>T70794 NZ_CP018908:902847-903716 [Streptococcus suis]
ATGGTAGGTAATGTTATTCAAATAGTAACAGAGAAATTATCATCTTTGCCTTTTATAGAAGGCATCGTATTAGGGGGCTC
ACGTGCAAGAGGCACCCATACAGAAAATTCTGATATAGATATCGGAATCTATTACAATTCAGACTCATTTGACCTGACAG
CGATTAATCAAATTGCTACAGAATTGGATGATAAAAATAGAAACAACCTTGTTGTGCCTCCCGGAGCGTGGGGTGATTGG
ATTAATGGCGGCGGATGGTTATTTATAAATGGGTATCATGTTGACTTGATTTTACGTGATATAAAACGGGTAGAACAAAT
AATCAAAGATACGGAGCAAGGAATTGTTACTGCCAATTATCAGACCGGGCATCCCCATGGTTATATAAGTGCAATGTATC
GTGGAGAATTAGCGATTAGTAAAATACTATATGCTAAGAACGAAAGCTTATGCGAATTAAAAAAGCAGGCAGAAATTTAC
CCTACTGCTCTAAAGAAAAGCTTGATGAACTTTTTTATATTTGAAGCTGAATTCTCTTTAATGTTTGTAAAAGCAAATGC
GGGGGTAGAGGATAAATATTATATTGCAGGCCATGTTTTTCGTATTATTTCATGCTTAAATCAAGTACTATTTGCATGTA
ATAATGCTTATTGCATTAACGAAAAGAAAGCTATAAAACTGCTTGAAACTTTTGAATATAAACCTGAAAAATATGCCGAA
AGAGTTAATCATATTTTTGAAGTACTCGGTCTTTCTCTTTTTGAATGCTACGATATGACCGAGAAACTTTATAAAGAAGT
GAATGAAATTGTATCGGAGATAAATAACTTTTTAAACGAGGAGAGTTCAGATGAAAGAAAACAAATATGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8365.68 Da
• Isoelectric Point: 4.5510

>AT70794 WP_000205227.1 NZ_CP018908:902608-902832 [Streptococcus suis]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Nucleotide

• Length: 225 bp

>AT70794 NZ_CP018908:902608-902832 [Streptococcus suis]
ATGACTACGGCAGAAATGATTAAAGAACTGTGTGAGCAAATGAATATAAGTGTTTCCGAACTTGCTAGACGTATTGGCCA
GACTCCACAGAATTTCAATAAAAAATTACAACGAGAAACAGTAACCTTGGATGAGTTGAAGGCCATTGCTGATGTGCTAG
GTGTCAAGTTTGTGCAGGCATTTATTTTACCAGATGGAGAAGAAATAAAAATATCTAACGAATAA

Structures

Toxin

• AlphaFold DB: R3JIN1