Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-couple_hipB
Location 910334..911586 Replicon chromosome
Accession NC_012924
Organism Streptococcus suis SC84

Toxin (Protein)


Gene name sezT Uniprot ID A0A0Z9JWN4
Locus tag SSUSC84_RS04490 Protein ID WP_011922437.1
Coordinates 910334..911110 (-) Length 259 a.a.

Antitoxin (Protein)


Gene name sezA Uniprot ID -
Locus tag SSUSC84_RS04495 Protein ID WP_012775115.1
Coordinates 911110..911586 (-) Length 159 a.a.

Genomic Context

SSUSC84_RS10750SSUSC84_RS04475SSUSC84_RS04480SSUSC84_RS04485SSUSC84_RS04490SSUSC84_RS04495SSUSC84_RS04500SSUSC84_RS04505SSUSC84_RS04510SSUSC84_RS04515SSUSC84_RS04520SSUSC84_RS04525
Location: 906034..906351 (318 bp)
Type: Others
Protein ID: Protein_831
Location: 905376..905690 (315 bp)
Type: Others
Protein ID: WP_000420682.1
Location: 906446..908263 (1818 bp)
Type: Others
Protein ID: WP_012775114.1
Location: 908250..910337 (2088 bp)
Type: Others
Protein ID: WP_011922436.1
Location: 910334..911110 (777 bp)
Type: Toxin
Protein ID: WP_011922437.1
Location: 911110..911586 (477 bp)
Type: Antitoxin
Protein ID: WP_012775115.1
Location: 911656..911946 (291 bp)
Type: Others
Protein ID: WP_024379089.1
Location: 911996..912385 (390 bp)
Type: Others
Protein ID: WP_011922440.1
Location: 912382..912609 (228 bp)
Type: Others
Protein ID: WP_011922441.1
Location: 912663..913739 (1077 bp)
Type: Others
Protein ID: WP_011922442.1
Location: 913778..914416 (639 bp)
Type: Others
Protein ID: WP_011922443.1
Location: 915817..916416 (600 bp)
Type: Others
Protein ID: WP_011922444.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SSUSC84_RS04475 (SSUSC84_0838)905376..905690-315WP_000420682.1YdcP family protein-
SSUSC84_RS10750906034..906351+318Protein_831ATP-binding protein-
SSUSC84_RS04480 (SSUSC84_0839)906446..908263-1818WP_012775114.1ATP-dependent helicase-
SSUSC84_RS04485 (SSUSC84_0840)908250..910337-2088WP_011922436.1AAA family ATPase-
SSUSC84_RS04490 (SSUSC84_0841)910334..911110-777WP_011922437.1zeta toxin family proteinToxin
SSUSC84_RS04495 (SSUSC84_0842)911110..911586-477WP_012775115.1helix-turn-helix domain-containing proteinAntitoxin
SSUSC84_RS04500 (SSUSC84_0843)911656..911946-291WP_024379089.1hypothetical protein-
SSUSC84_RS04505 (SSUSC84_0844)911996..912385-390WP_011922440.1methyl-accepting chemotaxis protein-
SSUSC84_RS04510 (SSUSC84_0845)912382..912609-228WP_011922441.1hypothetical protein-
SSUSC84_RS04515 (SSUSC84_0846)912663..913739-1077WP_011922442.1toprim domain-containing protein-
SSUSC84_RS04520 (SSUSC84_0847)913778..914416-639WP_011922443.1hypothetical protein-
SSUSC84_RS04525 (SSUSC84_0849)915817..916416-600WP_011922444.1response regulator transcription factor-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegrative and Conjugative Elementtet(M) / ant(6)-Ia-808819..964460155641


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 259 a.a.        Molecular weight: 29171.98 Da        Isoelectric Point: 5.2489

>T23992 WP_011922437.1 NC_012924:c911110-910334 [Streptococcus suis SC84]
MRLEEFSEAAFQKALQRTIRALIRGKTIPEQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLSELEREQLFDQIQIYQRDRTCIYDSEIDEGSAVEVLQECLFGQWSKVEEEML
KAGQERLGELVSANGEKK

Download         Length: 777 bp

>T23992 NC_012924:c911110-910334 [Streptococcus suis SC84]
ATGAGGTTGGAAGAATTTAGTGAGGCTGCATTTCAGAAGGCCTTACAGCGAACCATTCGGGCTTTAATCCGAGGCAAAAC
AATTCCAGAACAACCGAAAGCTATCTTACTTGGAGGACAAAGCGGAGCCGGTAAGACAACGATTCATCGGATTAAGCAAA
AGGAATTTCAAGGCAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAACATCCCAATTACTTAGCACTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACATCTGGTTGATGAACTTAGTAC
ACAAGGTTATCATTTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCGA
AAGGATACCAAGTTTCCTTAGCTGTGATTGGTACCAAACCAGAATTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCTATCGATCCTAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGATAA
CCTAAGCGAGTTAGAAAGAGAGCAACTCTTTGACCAAATTCAAATTTATCAAAGAGATAGAACTTGTATCTATGATTCTG
AAATTGATGAGGGATCCGCGGTAGAAGTGCTACAAGAATGCCTCTTTGGGCAATGGAGTAAAGTCGAGGAAGAGATGTTG
AAGGCCGGACAGGAACGGTTGGGGGAATTAGTCTCAGCTAATGGAGAGAAGAAATGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18282.69 Da        Isoelectric Point: 4.4750

>AT23992 WP_012775115.1 NC_012924:c911586-911110 [Streptococcus suis SC84]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp

>AT23992 NC_012924:c911586-911110 [Streptococcus suis SC84]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTCGGGATTTC
ACGCAATAGTCTGAGTCGCTACGAAAATGGAACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACTCCTGTCGAAGATTACCATCTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATCGATATCAAGATAGTCAGGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCAATACGAAAATTTACCTTGTCGATACTTTCGATG
AAATTGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTGGACATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Z9JWN4

Antitoxin

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Source
ID
Structure
No matching records found

References