Detailed information of TA system TA023992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-couple_hipB
• Location: 910334..911586
• Replicon: chromosome
• Accession: NC_012924
• Organism: Streptococcus suis SC84

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A0Z9JWN4
• Locus tag: SSUSC84_RS04490
• Protein ID: WP_011922437.1
• Coordinates: 910334..911110 (-)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: sezA
• Uniprot ID: -
• Locus tag: SSUSC84_RS04495
• Protein ID: WP_012775115.1
• Coordinates: 911110..911586 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSUSC84_RS04475 (SSUSC84_0838)	905376..905690	-	315	WP_000420682.1	YdcP family protein	-
SSUSC84_RS10750	906034..906351	+	318	Protein_831	ATP-binding protein	-
SSUSC84_RS04480 (SSUSC84_0839)	906446..908263	-	1818	WP_012775114.1	ATP-dependent helicase	-
SSUSC84_RS04485 (SSUSC84_0840)	908250..910337	-	2088	WP_011922436.1	AAA family ATPase	-
SSUSC84_RS04490 (SSUSC84_0841)	910334..911110	-	777	WP_011922437.1	zeta toxin family protein	Toxin
SSUSC84_RS04495 (SSUSC84_0842)	911110..911586	-	477	WP_012775115.1	helix-turn-helix domain-containing protein	Antitoxin
SSUSC84_RS04500 (SSUSC84_0843)	911656..911946	-	291	WP_024379089.1	hypothetical protein	-
SSUSC84_RS04505 (SSUSC84_0844)	911996..912385	-	390	WP_011922440.1	methyl-accepting chemotaxis protein	-
SSUSC84_RS04510 (SSUSC84_0845)	912382..912609	-	228	WP_011922441.1	hypothetical protein	-
SSUSC84_RS04515 (SSUSC84_0846)	912663..913739	-	1077	WP_011922442.1	toprim domain-containing protein	-
SSUSC84_RS04520 (SSUSC84_0847)	913778..914416	-	639	WP_011922443.1	hypothetical protein	-
SSUSC84_RS04525 (SSUSC84_0849)	915817..916416	-	600	WP_011922444.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NZ_CP007497 Streptococcus suis strain ZY05719 isolate diseased pig Integrative and Conjugative Element TA010053, TA046533, TA046534, TA046536 808718..964358 0 View NZ_CP018908 Streptococcus suis strain SS2-1 Integrative and Conjugative Element TA070792, TA070793, TA070794, TA070795 785098..940739 0 View NZ_CP020863 Streptococcus suis strain SC19 Integrative and Conjugative Element TA075581, TA075582, TA075583, TA075584 808893..964533 0 View NZ_CP007497 Streptococcus suis strain ZY05719 isolate diseased pig Integrative and Conjugative Element TA010053, TA046533, TA046534, TA046536 808718..964358 0	inside	Integrative and Conjugative Element	tet(M) / ant(6)-Ia	-	808819..964460	155641

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29171.98 Da
• Isoelectric Point: 5.2489

>T23992 WP_011922437.1 NC_012924:c911110-910334 [Streptococcus suis SC84]
MRLEEFSEAAFQKALQRTIRALIRGKTIPEQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLSELEREQLFDQIQIYQRDRTCIYDSEIDEGSAVEVLQECLFGQWSKVEEEML
KAGQERLGELVSANGEKK

Nucleotide

• Length: 777 bp

>T23992 NC_012924:c911110-910334 [Streptococcus suis SC84]
ATGAGGTTGGAAGAATTTAGTGAGGCTGCATTTCAGAAGGCCTTACAGCGAACCATTCGGGCTTTAATCCGAGGCAAAAC
AATTCCAGAACAACCGAAAGCTATCTTACTTGGAGGACAAAGCGGAGCCGGTAAGACAACGATTCATCGGATTAAGCAAA
AGGAATTTCAAGGCAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAACATCCCAATTACTTAGCACTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACATCTGGTTGATGAACTTAGTAC
ACAAGGTTATCATTTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCGA
AAGGATACCAAGTTTCCTTAGCTGTGATTGGTACCAAACCAGAATTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCTATCGATCCTAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGATAA
CCTAAGCGAGTTAGAAAGAGAGCAACTCTTTGACCAAATTCAAATTTATCAAAGAGATAGAACTTGTATCTATGATTCTG
AAATTGATGAGGGATCCGCGGTAGAAGTGCTACAAGAATGCCTCTTTGGGCAATGGAGTAAAGTCGAGGAAGAGATGTTG
AAGGCCGGACAGGAACGGTTGGGGGAATTAGTCTCAGCTAATGGAGAGAAGAAATGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18282.69 Da
• Isoelectric Point: 4.4750

>AT23992 WP_012775115.1 NC_012924:c911586-911110 [Streptococcus suis SC84]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT23992 NC_012924:c911586-911110 [Streptococcus suis SC84]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTCGGGATTTC
ACGCAATAGTCTGAGTCGCTACGAAAATGGAACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACTCCTGTCGAAGATTACCATCTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATCGATATCAAGATAGTCAGGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCAATACGAAAATTTACCTTGTCGATACTTTCGATG
AAATTGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTGGACATGGTGCATCATCGGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Z9JWN4