Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 858967..859459 Replicon chromosome
Accession NZ_CP020863
Organism Streptococcus suis strain SC19

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag B9H01_RS04345 Protein ID WP_011922404.1
Coordinates 858967..859224 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag B9H01_RS04350 Protein ID WP_012775104.1
Coordinates 859208..859459 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9H01_RS04325 854601..855671 + 1071 WP_012775101.1 tyrosine recombinase XerS -
B9H01_RS04330 855741..857249 - 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
B9H01_RS04335 857325..858266 - 942 WP_012775102.1 sensor histidine kinase -
B9H01_RS04340 858263..858928 - 666 WP_012775103.1 response regulator transcription factor -
B9H01_RS04345 858967..859224 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B9H01_RS04350 859208..859459 - 252 WP_012775104.1 hypothetical protein Antitoxin
B9H01_RS04355 859551..861521 - 1971 WP_012775105.1 FtsX-like permease family protein -
B9H01_RS04360 861522..862274 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
B9H01_RS04365 862410..863144 - 735 WP_011922410.1 ABC transporter permease -
B9H01_RS04370 863146..863892 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element tet(M) / ant(6)-Ia - 808893..964533 155640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T75581 WP_011922404.1 NZ_CP020863:c859224-858967 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T75581 NZ_CP020863:c859224-858967 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT75581 WP_012775104.1 NZ_CP020863:c859459-859208 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT75581 NZ_CP020863:c859459-859208 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References