Detailed information of TA system TA046534

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-couple_hipB
• Location: 910232..911484
• Replicon: chromosome
• Accession: NZ_CP007497
• Organism: Streptococcus suis strain ZY05719 isolate diseased pig

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A0Z9JWN4
• Locus tag: ZY05719_RS04510
• Protein ID: WP_011922437.1
• Coordinates: 910232..911008 (-)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: sezA
• Uniprot ID: -
• Locus tag: ZY05719_RS04515
• Protein ID: WP_012775115.1
• Coordinates: 911008..911484 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ZY05719_RS04495 (ZY05719_04510)	905274..905588	-	315	WP_000420682.1	YdcP family protein	-
ZY05719_RS10750	905932..906249	+	318	Protein_832	ATP-binding protein	-
ZY05719_RS04500 (ZY05719_04520)	906344..908161	-	1818	WP_012775114.1	ATP-dependent helicase	-
ZY05719_RS04505 (ZY05719_04525)	908148..910235	-	2088	WP_011922436.1	AAA family ATPase	-
ZY05719_RS04510 (ZY05719_04530)	910232..911008	-	777	WP_011922437.1	zeta toxin family protein	Toxin
ZY05719_RS04515 (ZY05719_04535)	911008..911484	-	477	WP_012775115.1	helix-turn-helix domain-containing protein	Antitoxin
ZY05719_RS04520 (ZY05719_04540)	911554..911844	-	291	WP_024379089.1	hypothetical protein	-
ZY05719_RS04525 (ZY05719_04545)	911894..912283	-	390	WP_011922440.1	methyl-accepting chemotaxis protein	-
ZY05719_RS04530 (ZY05719_04550)	912280..912507	-	228	WP_011922441.1	hypothetical protein	-
ZY05719_RS04535 (ZY05719_04555)	912561..913637	-	1077	WP_011922442.1	toprim domain-containing protein	-
ZY05719_RS04540 (ZY05719_04560)	913676..914314	-	639	WP_011922443.1	hypothetical protein	-
ZY05719_RS04545 (ZY05719_04570)	915715..916314	-	600	WP_011922444.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_012924 Streptococcus suis SC84 Integrative and Conjugative Element TA023991, TA023992, TA023993, TA023994 808819..964460 0 View NC_012924 Streptococcus suis SC84 Integrative and Conjugative Element TA023991, TA023992, TA023993, TA023994 808819..964460 0 View NZ_CP018908 Streptococcus suis strain SS2-1 Integrative and Conjugative Element TA070792, TA070793, TA070794, TA070795 785098..940739 0 View NZ_CP020863 Streptococcus suis strain SC19 Integrative and Conjugative Element TA075581, TA075582, TA075583, TA075584 808893..964533 0	inside	Integrative and Conjugative Element	tet(M) / ant(6)-Ia	-	808718..964358	155640

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29171.98 Da
• Isoelectric Point: 5.2489

>T46534 WP_011922437.1 NZ_CP007497:c911008-910232 [Streptococcus suis]
MRLEEFSEAAFQKALQRTIRALIRGKTIPEQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLSELEREQLFDQIQIYQRDRTCIYDSEIDEGSAVEVLQECLFGQWSKVEEEML
KAGQERLGELVSANGEKK

Nucleotide

• Length: 777 bp

>T46534 NZ_CP007497:c911008-910232 [Streptococcus suis]
ATGAGGTTGGAAGAATTTAGTGAGGCTGCATTTCAGAAGGCCTTACAGCGAACCATTCGGGCTTTAATCCGAGGCAAAAC
AATTCCAGAACAACCGAAAGCTATCTTACTTGGAGGACAAAGCGGAGCCGGTAAGACAACGATTCATCGGATTAAGCAAA
AGGAATTTCAAGGCAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAACATCCCAATTACTTAGCACTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACATCTGGTTGATGAACTTAGTAC
ACAAGGTTATCATTTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCGA
AAGGATACCAAGTTTCCTTAGCTGTGATTGGTACCAAACCAGAATTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCTATCGATCCTAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGATAA
CCTAAGCGAGTTAGAAAGAGAGCAACTCTTTGACCAAATTCAAATTTATCAAAGAGATAGAACTTGTATCTATGATTCTG
AAATTGATGAGGGATCCGCGGTAGAAGTGCTACAAGAATGCCTCTTTGGGCAATGGAGTAAAGTCGAGGAAGAGATGTTG
AAGGCCGGACAGGAACGGTTGGGGGAATTAGTCTCAGCTAATGGAGAGAAGAAATGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18282.69 Da
• Isoelectric Point: 4.4750

>AT46534 WP_012775115.1 NZ_CP007497:c911484-911008 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT46534 NZ_CP007497:c911484-911008 [Streptococcus suis]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTCGGGATTTC
ACGCAATAGTCTGAGTCGCTACGAAAATGGAACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACTCCTGTCGAAGATTACCATCTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATCGATATCAAGATAGTCAGGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCAATACGAAAATTTACCTTGTCGATACTTTCGATG
AAATTGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTGGACATGGTGCATCATCGGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Z9JWN4