Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGC   Type   Machinery gene
Locus tag   EL070_RS00690 Genome accession   NZ_LR134284
Coordinates   106296..106622 (+) Length   108 a.a.
NCBI ID   WP_002986552.1    Uniprot ID   A0A0H2UT15
Organism   Streptococcus pyogenes strain NCTC8232     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 101296..111622
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL070_RS00675 (NCTC8232_00134) - 103928..104293 (+) 366 WP_111705425.1 DUF1033 family protein -
  EL070_RS00680 (NCTC8232_00135) comGA 104386..105324 (+) 939 WP_002987773.1 competence type IV pilus ATPase ComGA Machinery gene
  EL070_RS00685 (NCTC8232_00136) comGB 105260..106294 (+) 1035 WP_011054115.1 competence type IV pilus assembly protein ComGB Machinery gene
  EL070_RS00690 (NCTC8232_00137) comGC 106296..106622 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  EL070_RS00695 (NCTC8232_00138) comGD 106597..107025 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD Machinery gene
  EL070_RS00700 (NCTC8232_00139) comGE 106982..107266 (+) 285 WP_002987779.1 competence type IV pilus minor pilin ComGE Machinery gene
  EL070_RS00705 (NCTC8232_00140) comGF 107259..107693 (+) 435 WP_002986542.1 competence type IV pilus minor pilin ComGF Machinery gene
  EL070_RS00710 (NCTC8232_00141) comGG 107677..108003 (+) 327 WP_002986539.1 competence type IV pilus minor pilin ComGG -
  EL070_RS00715 (NCTC8232_00142) comGH 108101..109054 (+) 954 WP_002987790.1 class I SAM-dependent methyltransferase Machinery gene
  EL070_RS00720 (NCTC8232_00143) - 109113..110309 (+) 1197 WP_002986533.1 acetate kinase -
  EL070_RS00725 - 110496..110804 (+) 309 Protein_92 hypothetical protein -

Sequence

Protein


Download         Length: 108 a.a.        Molecular weight: 12376.36 Da        Isoelectric Point: 9.8992

>NTDB_id=999988 EL070_RS00690 WP_002986552.1 106296..106622(+) (comGC) [Streptococcus pyogenes strain NCTC8232]
MINQWNNLRHKKLKGFTLLEMLLVILVISVLMLLFVPNLSKQKDRVTETGNAAVVKLVENQAELYELSQGSKPSLSQLKA
DGSITEKQEKAYQDYYDKHKNEKARLSN

Nucleotide


Download         Length: 327 bp        

>NTDB_id=999988 EL070_RS00690 WP_002986552.1 106296..106622(+) (comGC) [Streptococcus pyogenes strain NCTC8232]
ATGATTAATCAATGGAACAACTTACGACACAAGAAGCTAAAAGGATTTACTCTTCTAGAAATGTTATTGGTGATTCTTGT
CATCAGTGTTTTGATGCTATTATTTGTGCCTAATTTAAGCAAGCAAAAAGACAGGGTTACAGAAACAGGTAATGCCGCTG
TTGTTAAATTAGTGGAGAATCAAGCAGAACTATATGAATTATCTCAAGGCTCAAAACCAAGTTTGAGCCAGTTAAAGGCA
GATGGTAGTATCACTGAGAAACAAGAAAAAGCTTATCAAGACTATTATGACAAACATAAAAATGAAAAAGCCCGTCTTAG
CAATTAA

Domains

Predicted by InterProScan.

Prokaryotic N-terminal methylation motif (N_methyl)

(12-34)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UT15

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGC Streptococcus gordonii str. Challis substr. CH1

56.19

97.222

0.546
  comGC Lactococcus lactis subsp. cremoris KW2

56.863

94.444

0.537
  comGC/cglC Streptococcus mitis SK321

61.957

85.185

0.528
  comGC/cglC Streptococcus pneumoniae R6

60.87

85.185

0.519
  comGC/cglC Streptococcus pneumoniae TIGR4

60.87

85.185

0.519
  comGC/cglC Streptococcus pneumoniae D39

60.87

85.185

0.519
  comGC/cglC Streptococcus mitis NCTC 12261

60.87

85.185

0.519
  comGC/cglC Streptococcus pneumoniae Rx1

60.87

85.185

0.519
  comGC Streptococcus mutans UA140

55.208

88.889

0.491
  comGC Streptococcus mutans UA159

55.208

88.889

0.491
  comGC Streptococcus suis isolate S10

59.259

75

0.444

Multiple sequence alignment