Detailed information NTG0997557

Bioinformatically predicted

Overview

• Name: cinA
• Type: Machinery gene
• Locus tag: ABC806_RS01675
• Genome accession: NZ_CP155539
• Coordinates: 317915..319171 (+)
• Length: 418 a.a.
• NCBI ID: WP_000642718.1
• Uniprot ID: P54184
• Organism: Streptococcus pneumoniae TIGR4
• Function: facilitate localization of RecA (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	304408..325071	317915..319171	within	0

Gene organization within MGE regions

Location: 304408..325071

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC806_RS01610 (ABC806_01610)	-	304408..305820 (-)	1413	WP_000699968.1	S8 family serine peptidase	-
ABC806_RS01615 (ABC806_01615)	-	305844..307952 (-)	2109	WP_000701298.1	peptidase domain-containing ABC transporter	-
ABC806_RS01620 (ABC806_01620)	-	307949..308878 (-)	930	WP_000912954.1	M50 family metallopeptidase	-
ABC806_RS01625 (ABC806_01625)	-	308859..309563 (-)	705	WP_001033170.1	flavodoxin family protein	-
ABC806_RS01630 (ABC806_01630)	lanM	309913..312903 (-)	2991	WP_000875573.1	type 2 lanthipeptide synthetase LanM	-
ABC806_RS01635 (ABC806_01635)	pneA2	313019..313207 (-)	189	WP_000786759.1	two-peptide bacteriocin subunit PneA2	-
ABC806_RS01640 (ABC806_01640)	pneA1	313214..313438 (-)	225	WP_000181087.1	two-peptide bacteriocin subunit PneA1	-
ABC806_RS01645 (ABC806_01645)	-	313541..313711 (-)	171	WP_001227862.1	PhrA family quorum-sensing system peptide	-
ABC806_RS01650 (ABC806_01650)	-	313903..314766 (+)	864	WP_001093641.1	helix-turn-helix transcriptional regulator	-
ABC806_RS01655 (ABC806_01655)	comM	315149..315769 (+)	621	WP_000839908.1	hypothetical protein	Regulator
ABC806_RS01660 (ABC806_01660)	tsaE	315855..316298 (+)	444	WP_000288232.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	-
ABC806_RS01665 (ABC806_01665)	-	316288..316806 (+)	519	WP_000455537.1	GNAT family N-acetyltransferase	-
ABC806_RS01670 (ABC806_01670)	-	316814..317830 (+)	1017	WP_000239283.1	LCP family protein	-
ABC806_RS01675 (ABC806_01675)	cinA	317915..319171 (+)	1257	WP_000642718.1	competence/damage-inducible protein A	Machinery gene
ABC806_RS01680 (ABC806_01680)	recA	319226..320392 (+)	1167	WP_001085462.1	recombinase RecA	Machinery gene
ABC806_RS01685 (ABC806_01685)	-	320698..322068 (+)	1371	WP_001036271.1	MATE family efflux transporter	-
ABC806_RS01690 (ABC806_01690)	lytA	322444..323400 (+)	957	WP_000405234.1	N-acetylmuramoyl-L-alanine amidase LytA	-
ABC806_RS01695 (ABC806_01695)	-	323758..323919 (+)	162	WP_000289348.1	helix-turn-helix transcriptional regulator	-
ABC806_RS01700 (ABC806_01700)	-	323906..324112 (+)	207	WP_000366093.1	hypothetical protein	-
ABC806_RS01705 (ABC806_01705)	-	324158..324517 (+)	360	WP_000749819.1	hypothetical protein	-
ABC806_RS01710 (ABC806_01710)	-	324646..325071 (+)	426	WP_000204063.1	hypothetical protein	-

Sequence

Protein

• Length: 418 a.a.
• Molecular weight: 45091.48 Da
• Isoelectric Point: 4.6027

>NTDB_id=997557 ABC806_RS01675 WP_000642718.1 317915..319171(+) (cinA) [Streptococcus pneumoniae TIGR4]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFTLRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFKGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide

• Length: 1257 bp

>NTDB_id=997557 ABC806_RS01675 WP_000642718.1 317915..319171(+) (cinA) [Streptococcus pneumoniae TIGR4]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGGCAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTACCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTAAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

• Competence-damaged protein (CinA) (262-414)

• Damage-inducible protein CinA KH domain (CinA_KH) (177-240)

• Probable molybdopterin binding domain (MoCF_biosynth) (5-169)

3D structure

• AlphaFold DB: P54184

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cinA	Streptococcus pneumoniae TIGR4	100	100	1
cinA	Streptococcus pneumoniae Rx1	99.282	100	0.993
cinA	Streptococcus pneumoniae R6	99.282	100	0.993
cinA	Streptococcus pneumoniae D39	99.043	100	0.99
cinA	Streptococcus mitis SK321	93.541	100	0.935
cinA	Streptococcus mitis NCTC 12261	93.301	100	0.933
cinA	Streptococcus mutans UA159	70.813	100	0.708
cinA	Streptococcus suis isolate S10	54.808	99.522	0.545
cinA	Bacillus subtilis subsp. subtilis str. 168	45.455	100	0.455