Detailed information NTG0997214

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ABC814_RS11355
• Genome accession: NZ_CP155533
• Coordinates: 2199264..2200016 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain Spn1439-106
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2194264..2205016

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC814_RS11335 (ABC814_11335)	-	2196697..2198300 (-)	1604	Protein_2196	YhgE/Pip domain-containing protein	-
ABC814_RS11340 (ABC814_11340)	-	2198479..2199021 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
ABC814_RS11355 (ABC814_11355)	comE	2199264..2200016 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
ABC814_RS11360 (ABC814_11360)	comD/comD1	2200013..2201338 (-)	1326	WP_015898772.1	competence system sensor histidine kinase ComD	Regulator
ABC814_RS11365 (ABC814_11365)	comC/comC1	2201359..2201484 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
ABC814_RS11375 (ABC814_11375)	rlmH	2201767..2202246 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ABC814_RS11380 (ABC814_11380)	htrA	2202429..2203610 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
ABC814_RS11385 (ABC814_11385)	spo0J	2203668..2204426 (+)	759	WP_000410384.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=997214 ABC814_RS11355 WP_000866065.1 2199264..2200016(-) (comE) [Streptococcus pneumoniae strain Spn1439-106]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=997214 ABC814_RS11355 WP_000866065.1 2199264..2200016(-) (comE) [Streptococcus pneumoniae strain Spn1439-106]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAAC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408