Detailed information NTG0994392

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EW023_RS01270
• Genome accession: NZ_LR130239
• Coordinates: 225583..226323 (+)
• Length: 246 a.a.
• NCBI ID: WP_002986100.1
• Uniprot ID: A0A0H2UT50
• Organism: Streptococcus pyogenes strain PS003 isolate PS003
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 220583..231323

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EW023_RS01255	gltX	221113..222558 (+)	1446	WP_023612410.1	glutamate--tRNA ligase	-
EW023_RS01260	-	222953..224299 (+)	1347	WP_023610780.1	sensor histidine kinase	-
EW023_RS01265	-	224296..225579 (+)	1284	WP_010921869.1	sensor histidine kinase	-
EW023_RS01270	comE/blpR	225583..226323 (+)	741	WP_002986100.1	response regulator transcription factor	Regulator
EW023_RS01275	rnpA	226863..227222 (+)	360	WP_002992035.1	ribonuclease P protein component	-
EW023_RS01280	-	227188..228015 (+)	828	WP_002991181.1	YidC/Oxa1 family membrane protein insertase	-
EW023_RS01285	jag	228027..228941 (+)	915	WP_023612417.1	RNA-binding cell elongation regulator Jag/EloR	-
EW023_RS01290	rpmH	229256..229390 (+)	135	WP_002885866.1	50S ribosomal protein L34	-
EW023_RS01295	-	229664..230368 (+)	705	WP_011528225.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28881.47 Da
• Isoelectric Point: 6.4841

>NTDB_id=994392 EW023_RS01270 WP_002986100.1 225583..226323(+) (comE/blpR) [Streptococcus pyogenes strain PS003 isolate PS003]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=994392 EW023_RS01270 WP_002986100.1 225583..226323(+) (comE/blpR) [Streptococcus pyogenes strain PS003 isolate PS003]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATTCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCTCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

3D structure

• AlphaFold DB: A0A0H2UT50

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37