Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   R8624_RS08855 Genome accession   NZ_AP026930
Coordinates   1723348..1724604 (-) Length   418 a.a.
NCBI ID   WP_000642707.1    Uniprot ID   A0A0B7L5W3
Organism   Streptococcus pneumoniae strain PZ900701208     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1718348..1729604
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8624_RS08830 (PC1195_17280) - 1718419..1718625 (-) 207 WP_000366088.1 hypothetical protein -
  R8624_RS08835 (PC1195_17290) - 1718612..1718773 (-) 162 WP_001055999.1 helix-turn-helix domain-containing protein -
  R8624_RS08840 (PC1195_17300) lytA 1719119..1720075 (-) 957 WP_001862690.1 N-acetylmuramoyl-L-alanine amidase LytA -
  R8624_RS08845 (PC1195_17310) - 1720451..1721821 (-) 1371 WP_050311830.1 MATE family efflux transporter -
  R8624_RS08850 (PC1195_17320) recA 1722127..1723293 (-) 1167 WP_001085463.1 recombinase RecA Machinery gene
  R8624_RS08855 (PC1195_17330) cinA 1723348..1724604 (-) 1257 WP_000642707.1 competence/damage-inducible protein A Machinery gene
  R8624_RS08860 (PC1195_17340) brpA 1724689..1725705 (-) 1017 WP_000239284.1 biofilm formation/cell division transcriptional regulator BrpA -
  R8624_RS08865 (PC1195_17350) - 1725713..1726231 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  R8624_RS08870 (PC1195_17360) tsaE 1726221..1726664 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  R8624_RS08875 (PC1195_17370) comM 1726750..1727370 (-) 621 WP_000839908.1 hypothetical protein Regulator
  R8624_RS08880 (PC1195_17380) - 1727753..1728616 (-) 864 WP_001093628.1 helix-turn-helix domain-containing protein -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45061.46 Da        Isoelectric Point: 4.6027

>NTDB_id=98765 R8624_RS08855 WP_000642707.1 1723348..1724604(-) (cinA) [Streptococcus pneumoniae strain PZ900701208]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFKGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=98765 R8624_RS08855 WP_000642707.1 1723348..1724604(-) (cinA) [Streptococcus pneumoniae strain PZ900701208]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTAAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(262-414)

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7L5W3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae TIGR4

99.761

100

0.998
  cinA Streptococcus pneumoniae Rx1

99.522

100

0.995
  cinA Streptococcus pneumoniae R6

99.522

100

0.995
  cinA Streptococcus pneumoniae D39

99.282

100

0.993
  cinA Streptococcus mitis SK321

93.78

100

0.938
  cinA Streptococcus mitis NCTC 12261

93.541

100

0.935
  cinA Streptococcus mutans UA159

71.053

100

0.711
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment