Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   R8613_RS09620 Genome accession   NZ_AP026919
Coordinates   1837167..1838423 (-) Length   418 a.a.
NCBI ID   WP_000642709.1    Uniprot ID   A0A0E8AGF5
Organism   Streptococcus pneumoniae strain PZ900700012     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1818699..1852257 1837167..1838423 within 0


Gene organization within MGE regions


Location: 1818699..1852257
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8613_RS09525 (PC0012_18460) - 1819441..1820274 (+) 834 WP_001842810.1 glycerophosphodiester phosphodiesterase family protein -
  R8613_RS09530 (PC0012_18470) - 1820317..1821378 (+) 1062 WP_000475762.1 extracellular solute-binding protein -
  R8613_RS09535 (PC0012_18480) - 1821395..1822399 (+) 1005 WP_000627602.1 ABC transporter ATP-binding protein -
  R8613_RS09540 (PC0012_18490) - 1822411..1824105 (+) 1695 WP_001232289.1 iron ABC transporter permease -
  R8613_RS09545 (PC0012_18500) - 1824107..1824808 (+) 702 WP_001054457.1 MgtC/SapB family protein -
  R8613_RS09550 (PC0012_18510) - 1824855..1825454 (+) 600 WP_001021235.1 HAD family phosphatase -
  R8613_RS09555 (PC0012_18520) - 1825464..1827491 (+) 2028 WP_000256297.1 ABC transporter substrate-binding protein -
  R8613_RS09560 - 1827650..1828454 (+) 805 WP_317648236.1 IS5 family transposase -
  R8613_RS09565 (PC0012_18550) - 1829211..1829471 (-) 261 WP_050218556.1 hypothetical protein -
  R8613_RS09570 (PC0012_18560) - 1829530..1830081 (-) 552 WP_001111250.1 hypothetical protein -
  R8613_RS09575 (PC0012_18570) - 1830071..1830268 (-) 198 WP_000890144.1 hypothetical protein -
  R8613_RS09580 (PC0012_18580) - 1830272..1830856 (-) 585 WP_081544138.1 hypothetical protein -
  R8613_RS09585 (PC0012_18590) - 1831265..1831690 (-) 426 WP_000204070.1 hypothetical protein -
  R8613_RS09590 (PC0012_18600) - 1831819..1832178 (-) 360 WP_000749821.1 ImmA/IrrE family metallo-endopeptidase -
  R8613_RS09595 (PC0012_18610) - 1832224..1832430 (-) 207 WP_000366087.1 hypothetical protein -
  R8613_RS09600 (PC0012_18620) - 1832417..1832578 (-) 162 WP_000289348.1 helix-turn-helix domain-containing protein -
  R8613_RS09605 (PC0012_18630) lytA 1832937..1833893 (-) 957 WP_000405240.1 N-acetylmuramoyl-L-alanine amidase LytA -
  R8613_RS09610 (PC0012_18640) - 1834269..1835639 (-) 1371 WP_001036293.1 MATE family efflux transporter -
  R8613_RS09615 (PC0012_18650) recA 1835946..1837112 (-) 1167 WP_001085463.1 recombinase RecA Machinery gene
  R8613_RS09620 (PC0012_18660) cinA 1837167..1838423 (-) 1257 WP_000642709.1 competence/damage-inducible protein A Machinery gene
  R8613_RS09625 (PC0012_18670) brpA 1838508..1839524 (-) 1017 WP_000239282.1 biofilm formation/cell division transcriptional regulator BrpA -
  R8613_RS09630 (PC0012_18680) - 1839532..1840050 (-) 519 WP_050116027.1 GNAT family N-acetyltransferase -
  R8613_RS09635 (PC0012_18690) tsaE 1840040..1840483 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  R8613_RS09640 (PC0012_18700) comM 1840569..1841189 (-) 621 WP_000839908.1 hypothetical protein Regulator
  R8613_RS09645 (PC0012_18710) - 1841571..1842434 (-) 864 WP_001093620.1 helix-turn-helix domain-containing protein -
  R8613_RS09650 (PC0012_18720) - 1842626..1842796 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  R8613_RS09655 (PC0012_18730) pneA1 1842899..1843123 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  R8613_RS09660 (PC0012_18740) pneA2 1843130..1843318 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  R8613_RS09665 (PC0012_18750) - 1843435..1846425 (+) 2991 WP_000875571.1 type 2 lanthipeptide synthetase LanM family protein -
  R8613_RS09670 (PC0012_18760) - 1846775..1847479 (+) 705 WP_001033170.1 flavodoxin family protein -
  R8613_RS09675 (PC0012_18770) - 1847460..1848389 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  R8613_RS09680 (PC0012_18780) - 1848386..1850494 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  R8613_RS09685 (PC0012_18790) - 1850518..1852257 (+) 1740 WP_000699969.1 S8 family serine peptidase -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45075.48 Da        Isoelectric Point: 4.6064

>NTDB_id=97897 R8613_RS09620 WP_000642709.1 1837167..1838423(-) (cinA) [Streptococcus pneumoniae strain PZ900700012]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFKGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQEQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=97897 R8613_RS09620 WP_000642709.1 1837167..1838423(-) (cinA) [Streptococcus pneumoniae strain PZ900700012]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGCTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTAAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACCGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGAGCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CATATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Competence-damaged protein (CinA)

(262-414)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E8AGF5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae TIGR4

99.522

100

0.995
  cinA Streptococcus pneumoniae Rx1

99.282

100

0.993
  cinA Streptococcus pneumoniae R6

99.282

100

0.993
  cinA Streptococcus pneumoniae D39

99.043

100

0.99
  cinA Streptococcus mitis SK321

94.019

100

0.94
  cinA Streptococcus mitis NCTC 12261

93.78

100

0.938
  cinA Streptococcus mutans UA159

71.053

100

0.711
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment