Detailed information
Bioinformatically predicted
Overview
| Name | comM | Type | Regulator |
| Locus tag | R8613_RS09640 | Genome accession | NZ_AP026919 |
| Coordinates | 1840569..1841189 (-) | Length | 206 a.a. |
| NCBI ID | WP_000839908.1 | Uniprot ID | A0A0B7M636 |
| Organism | Streptococcus pneumoniae strain PZ900700012 | ||
| Function | fratricide immunity (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Genomic island | 1818699..1852257 | 1840569..1841189 | within | 0 |
Gene organization within MGE regions
Location: 1818699..1852257
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| R8613_RS09525 (PC0012_18460) | - | 1819441..1820274 (+) | 834 | WP_001842810.1 | glycerophosphodiester phosphodiesterase family protein | - |
| R8613_RS09530 (PC0012_18470) | - | 1820317..1821378 (+) | 1062 | WP_000475762.1 | extracellular solute-binding protein | - |
| R8613_RS09535 (PC0012_18480) | - | 1821395..1822399 (+) | 1005 | WP_000627602.1 | ABC transporter ATP-binding protein | - |
| R8613_RS09540 (PC0012_18490) | - | 1822411..1824105 (+) | 1695 | WP_001232289.1 | iron ABC transporter permease | - |
| R8613_RS09545 (PC0012_18500) | - | 1824107..1824808 (+) | 702 | WP_001054457.1 | MgtC/SapB family protein | - |
| R8613_RS09550 (PC0012_18510) | - | 1824855..1825454 (+) | 600 | WP_001021235.1 | HAD family phosphatase | - |
| R8613_RS09555 (PC0012_18520) | - | 1825464..1827491 (+) | 2028 | WP_000256297.1 | ABC transporter substrate-binding protein | - |
| R8613_RS09560 | - | 1827650..1828454 (+) | 805 | WP_317648236.1 | IS5 family transposase | - |
| R8613_RS09565 (PC0012_18550) | - | 1829211..1829471 (-) | 261 | WP_050218556.1 | hypothetical protein | - |
| R8613_RS09570 (PC0012_18560) | - | 1829530..1830081 (-) | 552 | WP_001111250.1 | hypothetical protein | - |
| R8613_RS09575 (PC0012_18570) | - | 1830071..1830268 (-) | 198 | WP_000890144.1 | hypothetical protein | - |
| R8613_RS09580 (PC0012_18580) | - | 1830272..1830856 (-) | 585 | WP_081544138.1 | hypothetical protein | - |
| R8613_RS09585 (PC0012_18590) | - | 1831265..1831690 (-) | 426 | WP_000204070.1 | hypothetical protein | - |
| R8613_RS09590 (PC0012_18600) | - | 1831819..1832178 (-) | 360 | WP_000749821.1 | ImmA/IrrE family metallo-endopeptidase | - |
| R8613_RS09595 (PC0012_18610) | - | 1832224..1832430 (-) | 207 | WP_000366087.1 | hypothetical protein | - |
| R8613_RS09600 (PC0012_18620) | - | 1832417..1832578 (-) | 162 | WP_000289348.1 | helix-turn-helix domain-containing protein | - |
| R8613_RS09605 (PC0012_18630) | lytA | 1832937..1833893 (-) | 957 | WP_000405240.1 | N-acetylmuramoyl-L-alanine amidase LytA | - |
| R8613_RS09610 (PC0012_18640) | - | 1834269..1835639 (-) | 1371 | WP_001036293.1 | MATE family efflux transporter | - |
| R8613_RS09615 (PC0012_18650) | recA | 1835946..1837112 (-) | 1167 | WP_001085463.1 | recombinase RecA | Machinery gene |
| R8613_RS09620 (PC0012_18660) | cinA | 1837167..1838423 (-) | 1257 | WP_000642709.1 | competence/damage-inducible protein A | Machinery gene |
| R8613_RS09625 (PC0012_18670) | brpA | 1838508..1839524 (-) | 1017 | WP_000239282.1 | biofilm formation/cell division transcriptional regulator BrpA | - |
| R8613_RS09630 (PC0012_18680) | - | 1839532..1840050 (-) | 519 | WP_050116027.1 | GNAT family N-acetyltransferase | - |
| R8613_RS09635 (PC0012_18690) | tsaE | 1840040..1840483 (-) | 444 | WP_000288232.1 | tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE | - |
| R8613_RS09640 (PC0012_18700) | comM | 1840569..1841189 (-) | 621 | WP_000839908.1 | hypothetical protein | Regulator |
| R8613_RS09645 (PC0012_18710) | - | 1841571..1842434 (-) | 864 | WP_001093620.1 | helix-turn-helix domain-containing protein | - |
| R8613_RS09650 (PC0012_18720) | - | 1842626..1842796 (+) | 171 | WP_001227862.1 | PhrA family quorum-sensing system peptide | - |
| R8613_RS09655 (PC0012_18730) | pneA1 | 1842899..1843123 (+) | 225 | WP_000181087.1 | two-peptide bacteriocin subunit PneA1 | - |
| R8613_RS09660 (PC0012_18740) | pneA2 | 1843130..1843318 (+) | 189 | WP_000786759.1 | two-peptide bacteriocin subunit PneA2 | - |
| R8613_RS09665 (PC0012_18750) | - | 1843435..1846425 (+) | 2991 | WP_000875571.1 | type 2 lanthipeptide synthetase LanM family protein | - |
| R8613_RS09670 (PC0012_18760) | - | 1846775..1847479 (+) | 705 | WP_001033170.1 | flavodoxin family protein | - |
| R8613_RS09675 (PC0012_18770) | - | 1847460..1848389 (+) | 930 | WP_000912954.1 | M50 family metallopeptidase | - |
| R8613_RS09680 (PC0012_18780) | - | 1848386..1850494 (+) | 2109 | WP_000701298.1 | peptidase domain-containing ABC transporter | - |
| R8613_RS09685 (PC0012_18790) | - | 1850518..1852257 (+) | 1740 | WP_000699969.1 | S8 family serine peptidase | - |
Sequence
Protein
Download Length: 206 a.a. Molecular weight: 23552.72 Da Isoelectric Point: 10.1254
>NTDB_id=97898 R8613_RS09640 WP_000839908.1 1840569..1841189(-) (comM) [Streptococcus pneumoniae strain PZ900700012]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
Nucleotide
Download Length: 621 bp
>NTDB_id=97898 R8613_RS09640 WP_000839908.1 1840569..1841189(-) (comM) [Streptococcus pneumoniae strain PZ900700012]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACTCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTGGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATATTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACTCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTGGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATATTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
Domains
No domain identified.
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comM | Streptococcus pneumoniae D39 |
100 |
100 |
1 |
| comM | Streptococcus pneumoniae R6 |
100 |
100 |
1 |
| comM | Streptococcus pneumoniae TIGR4 |
100 |
100 |
1 |
| comM | Streptococcus mitis NCTC 12261 |
38.974 |
94.66 |
0.369 |
| comM | Streptococcus mitis SK321 |
38.974 |
94.66 |
0.369 |